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  • 1
    Online Resource
    Online Resource
    The serotonin receptor 2A (HTR2A) rs6313 variant is associated with higher ongoing pain and signs of central sensitization in neuropathic pain patients
    Wiley ; 2021
    In:  European Journal of Pain Vol. 25, No. 3 ( 2021-03), p. 595-611
    Details
    In: European Journal of Pain, Wiley, Vol. 25, No. 3 ( 2021-03), p. 595-611
    Abstract: The serotonin receptor 2A (HTR2A) has been described as an important facilitation mediator of spinal nociceptive processing leading to central sensitization (CS) in animal models of chronic pain. However, whether HTR2A single nucleotide variants (SNVs) modulate neuropathic pain states in patients has not been investigated so far. The aim of this study was to elucidate the potential association of HTR2A variants with sensory abnormalities or ongoing pain in neuropathic pain patients. Methods At total of 240 neuropathic pain patients and 253 healthy volunteers were included. Patients were phenotypically characterized using standardized quantitative sensory testing (QST). Patients and controls were genotyped for HTR2A g.‐1438G  〉  A (rs6311) and c.102C  〉  T (rs6313). Genotype‐related differences in QST parameters were assessed considering QST profile clusters, principal somatosensory components and sex. Results There was an equal distribution of rs6313 and linked rs6311 between patients and controls. However, the rs6313 variant was significantly associated with a principal component of pinprick hyperalgesia and dynamic mechanical allodynia, indicating enhanced CS in patients with sensory loss (−0.34 ± 0.15 vs. +0.31 ± 0.11 vs., p   〈  .001). In this cluster, the variant allele was also associated with single QST parameters of pinprick hyperalgesia (MPT, +0.64 ± 0.18 vs. −0.34 ± 0.23 p  = .002; MPS, +0.66 ± 0.17 vs. −0.09 ± 0.23, p  = .009) and ongoing pain was increased by 30%. Conclusions The specific association of the rs6313 variant with pinprick hyperalgesia and increased levels of ongoing pain suggests that the HTR2A receptor might be an important modulator in the development of CS in neuropathic pain. Significance This article presents new insights into serotonin receptor 2A‐mediating mechanisms of central sensitization in neuropathic pain patients. The rs6313 variant allele was associated with increased mechanical pinprick sensitivity and increased levels of ongoing pain supporting a contribution of central sensitization in the genesis of ongoing pain providing a possible route for mechanism‐based therapies.
    Type of Medium: Online Resource
    ISSN: 1090-3801 , 1532-2149
    URL: Issue
    URL: Article
    DOI: 10.1002/ejp.v25.3
    DOI: 10.1002/ejp.1696
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2002493-9
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  • 2
    Online Resource
    Online Resource
    Impaired glymphatic flow as a potential driver of pain chronification
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Pain Vol. 164, No. 10 ( 2023-10), p. 2191-2195
    Details
    In: Pain, Ovid Technologies (Wolters Kluwer Health), Vol. 164, No. 10 ( 2023-10), p. 2191-2195
    Type of Medium: Online Resource
    ISSN: 0304-3959 , 1872-6623
    URL: Article
    DOI: 10.1097/j.pain.0000000000002979
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 1494115-6
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  • 3
    Online Resource
    Online Resource
    The early influence of COVID-19 pandemic-associated restrictions on pain, mood, and everyday life of patients with painful polyneuropathy
    Ovid Technologies (Wolters Kluwer Health) ; 2020
    In:  PAIN Reports Vol. 5, No. 6 ( 2020-10-14), p. e858-
    Details
    In: PAIN Reports, Ovid Technologies (Wolters Kluwer Health), Vol. 5, No. 6 ( 2020-10-14), p. e858-
    Type of Medium: Online Resource
    ISSN: 2471-2531
    URL: Article
    DOI: 10.1097/PR9.0000000000000858
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2898347-6
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  • 4
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    Online Resource
    The pandemic’s effect on a patient cohort with painful polyneuropathy in 2020: A longitudinal study on pain, mood, and everyday life
    Ovid Technologies (Wolters Kluwer Health) ; 2022
    In:  Medicine Vol. 101, No. 50 ( 2022-12-16), p. e32054-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 101, No. 50 ( 2022-12-16), p. e32054-
    Abstract: In the early phase of the COVID pandemic 2020, we demonstrated how patients with painful polyneuropathy, against our expectations, did not experience a deterioration of their neuropathic pain. We hypothesized that our assessed measures, that is, pain intensity and characteristics, emotional wellbeing, and everyday life, would deteriorate in the further course of the pandemic according to the phases of disaster management. Thus, the aim of our study was to investigate patients repeatedly under varying pandemic conditions from March until December 2020. Sixty-three patients were investigated with validated questionnaires (brief pain inventory [BPI], neuropathic pain symptom inventory [NPSI] , pain catastrophizing scale [PCS], patient-reported outcomes measurement information system [PROMIS] pain interference/sleep disturbance/fatigue/ depression/anxiety, EuroQol 5 dimensions 5 level version [EQ-5D-5L]) and a pandemic-specific, self-designed questionnaire. The data from the beginning of the pandemic with severe restrictions, during summer with loosened regulations and from December 2020 with reinstalled, severe restrictions were compared with an observational design. Patients reported higher pain severity when restrictions were lower. Sleep, mood, and quality of life did not change in the course of the pandemic in the validated measures. Pain interference significantly decreased during the study independent from restrictions. Patients who reported medical disadvantages had a lower quality of life upon EuroQol 5 dimension (EQ-5D) and were significantly more worried about their health. The perception of pain intensity was dependent on pandemic severity. Sleep, mood, and quality of life did not change significantly in validated measures. Continued medical care seems decisive to prevent worsening of pain and quality of life.
    Type of Medium: Online Resource
    ISSN: 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000032054
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2022
    detail.hit.zdb_id: 2049818-4
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  • 5
    Online Resource
    Online Resource
    Unusual Pain Disorders – What Can Be Learned from Them?
    Informa UK Limited ; 2021
    In:  Journal of Pain Research Vol. Volume 13 ( 2021-03), p. 3539-3554
    Details
    In: Journal of Pain Research, Informa UK Limited, Vol. Volume 13 ( 2021-03), p. 3539-3554
    Type of Medium: Online Resource
    ISSN: 1178-7090
    URL: Article
    DOI: 10.2147/JPR.S287603
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2495284-9
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  • 6
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    Online Resource
    Diagnostik und Therapie neuropathischer Schmerzen
    Georg Thieme Verlag KG ; 2021
    In:  Nervenheilkunde Vol. 40, No. 03 ( 2021-03), p. 104-119
    Details
    In: Nervenheilkunde, Georg Thieme Verlag KG, Vol. 40, No. 03 ( 2021-03), p. 104-119
    Abstract: Die Ätiologie neuropathischer Schmerzen gründet auf einer Schädigung des somatosensorischen Systems. Sie unterscheiden sich von nozizeptiven Schmerzen, bei welchen das somatosensorische System intakt ist, nicht nur in ihrer Schmerzqualität, sondern auch in ihrer Therapie. Periphere neuropathische Schmerzen, beispielsweise aufgrund einer Polyneuropathie, werden von zentralen neuropathischen Schmerzen, beispielsweise als Folge eines Schlaganfalls abgegrenzt. Bei der Diagnostik neuropathischer Schmerzen, wird zwischen „sicheren“, „wahrscheinlichen“, „möglichen“ und „unwahrscheinlichen“ neuropathischen Schmerzen unterschieden. Eine gründliche Anamnese, welche durch Fragebögen ergänzt werden kann, und körperliche Untersuchung sind bei der Diagnostik erforderlich. Zum Erkennen der „Positiv“- und „Negativsymptome“, welche für neuropathische Schmerzen charakteristisch sind, kann man sich einfacher „Bedside-Tools“ bedienen. Für die Sicherung der Diagnose können die Quantitative Sensorische Testung (QST), Methoden der Bildgebung und der klassischen Elektrophysiologie sowie die Hautbiopsie und weitere spezialisierte Methoden eingesetzt werden. Das Ansprechen neuropathischer Schmerzen auf klassische Analgetika ist in der Regel schlecht. Daher werden als Medikamente erster Wahl Antikonvulsiva und Antidepressiva eingesetzt. Auch topisch applizierte Substanzen wie Capsaicin oder Lidocain und niedrigpotente Opioide finden in der Therapie neuropathischer Schmerzen häufig ihre Anwendung. Oft ist eine Kombination mehrerer Substanzen erforderlich. Die Trigeminusneuralgie sowie der zentrale Schmerz nach Schlaganfall oder bei Multipler Sklerose weisen Besonderheiten in ihrer Diagnostik und Therapie auf, welchen in Exkursen Aufmerksamkeit gewidmet werden soll.
    Type of Medium: Online Resource
    ISSN: 0722-1541 , 2567-5788
    URL: Article
    DOI: 10.1055/a-1333-6520
    RVK:
    XA 10000
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
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  • 7
    Online Resource
    Online Resource
    Pain symptoms during and after a COVID-19 infection
    Springer Science and Business Media LLC ; 2022
    In:  MMW - Fortschritte der Medizin Vol. 164, No. 5 ( 2022-03), p. 60-62
    Details
    In: MMW - Fortschritte der Medizin, Springer Science and Business Media LLC, Vol. 164, No. 5 ( 2022-03), p. 60-62
    Type of Medium: Online Resource
    ISSN: 1438-3276 , 1613-3560
    URL: Article
    DOI: 10.1007/s15006-022-0773-7
    Language: German
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2173071-4
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  • 8
    Online Resource
    Online Resource
    Datasheet1.docx
    Frontiers Media SA ; 2024
    In:  Frontiers in Pain Research Vol. 5 ( 2024-5-15)
    Details
    In: Frontiers in Pain Research, Frontiers Media SA, Vol. 5 ( 2024-5-15)
    Abstract: Fabry disease (FD) causes cold-evoked pain and impaired cold perception through small fiber damage, which also occurs in polyneuropathies (PNP) of other origins. The integrity of thinly myelinated fibers and the spinothalamic tract is assessable by cold-evoked potentials (CEPs). In this study, we aimed to assess the clinical value of CEP by investigating its associations with pain, autonomic measures, sensory loss, and neuropathic signs. Methods CEPs were examined at the hand and foot dorsum of patients with FD ( n = 16) and PNP ( n = 21) and healthy controls ( n = 23). Sensory phenotyping was performed using quantitative sensory testing (QST). The painDETECT questionnaire (PDQ), FabryScan, and measures for the autonomic nervous system were applied. Group comparisons and correlation analyses were performed. Results CEPs of 87.5% of the FD and 85.7% of the PNP patients were eligible for statistical analysis. In all patients combined, CEP data correlated significantly with cold detection loss, PDQ items, pain, and autonomic measures. Abnormal CEP latency in FD patients was associated with an abnormal heart frequency variability item ( r = −0.684; adjusted p = 0.04). In PNP patients, CEP latency correlated significantly with PDQ items, and CEP amplitude correlated with autonomic measures ( r = 0.688, adjusted p = 0.008; r = 0.619, adjusted p = 0.024). Furthermore, mechanical pain thresholds differed significantly between FD (gain range) and PNP patients (loss range) ( p = 0.01). Conclusions Abnormal CEPs were associated with current pain, neuropathic signs and symptoms, and an abnormal function of the autonomic nervous system. The latter has not been mirrored by QST parameters. Therefore, CEPs appear to deliver a wider spectrum of information on the sensory nervous system than QST alone.
    Type of Medium: Online Resource
    ISSN: 2673-561X
    URL: Article
    URL: Article
    DOI: 10.3389/fpain.2024.1352711
    DOI: 10.3389/fpain.2024.1352711.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 3035397-X
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  • 9
    Online Resource
    Online Resource
    Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls
    MDPI AG ; 2023
    In:  Biomedicines Vol. 11, No. 3 ( 2023-03-02), p. 764-
    Details
    In: Biomedicines, MDPI AG, Vol. 11, No. 3 ( 2023-03-02), p. 764-
    Abstract: Polyneuropathies (PNP) are the most common type of disorder of the peripheral nervous system in adults. However, information on microRNA expression in PNP is lacking. Following microRNA sequencing, we compared the expression of microRNAs in the serum of patients experiencing chronic painful PNP with healthy age-matched controls. We have been able to identify four microRNAs (hsa-miR-3135b, hsa-miR-584-5p, hsa-miR-12136, and hsa-miR-550a-3p) that provide possible molecular links between degenerative processes, blood flow regulation, and signal transduction, that eventually lead to PNP. In addition, these microRNAs are discussed regarding the targeting of proteins that are involved in high blood flow/pressure and neural activity dysregulations/disbalances, presumably resulting in PNP-typical symptoms such as chronical numbness/pain. Within our study, we have identified four microRNAs that may serve as potential novel biomarkers of chronic painful PNP, and that may potentially bear therapeutic implications.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    URL: Article
    DOI: 10.3390/biomedicines11030764
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2720867-9
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  • 10
    Online Resource
    Online Resource
    The association of self-reported symptoms of central sensitization and sleep disturbances in neuropathic pain
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  PAIN Reports Vol. 8, No. 5 ( 2023-9-26), p. e1098-
    Details
    In: PAIN Reports, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 5 ( 2023-9-26), p. e1098-
    Abstract: Patients with neuropathic pain (NP) report a higher impairment of quality of life and sleep than patients with chronic pain without neuropathic characteristics. These include somatosensory peculiarities like allodynia, a surrogate marker for central sensitization. Objectives: This study aimed to investigate the relation between symptoms of central sensitization and sleep disturbances in patients with NP. Methods: Within this cross-sectional study, data sets of 3339 patients with chronic NP syndromes (painful diabetic polyneuropathy, n = 543; postherpetic neuralgia, n = 1480) or complex regional pain syndromes (CRPS, n = 1316) were analyzed. Neuropathic pain symptoms were assessed with the painDETECT questionnaire (PD-Q), depression with the Patient Health Questionnaire-9, and sleep impairment with items of the Medical Outcomes Study Sleep Scale in 4 subscales. The association of demographic/clinical data, somatosensory phenotype, depression, and pain intensity with sleep impairment was assessed by unadjusted Spearman correlation analyses and multivariable regression analyses. Results: Sleep impairment was observed in all pain aetiologies although with some significant differences in the single sleep items. The intensity of the individual PD-Q items differed to some extent between the 3 pain entities, whereas the PD-Q sum score was similar. Thermal hyperalgesia and burning assessed by the PD-Q were significantly associated with sleep disturbance, adequacy, and quantity but not with sleep somnolence. Only depression and self-reported allodynia had a significant relation to all 4 sleep elements. Conclusion: Beside depression, allodynia as a surrogate marker hints to a possible impact of central sensitization on the sleep disruption of patients with NP.
    Type of Medium: Online Resource
    ISSN: 2471-2531
    URL: Article
    DOI: 10.1097/PR9.0000000000001098
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2898347-6
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