In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2022-7-12), p. e0270970-
Abstract:
There is an increasing demand in developing new, effective, and affordable anti-cancer against colon and rectal. In this study, our aim is to identify the potential anthraquinone compounds from the root bark of Morinda citrifolia to be tested in vitro against colorectal cancer cell lines. Eight potential anthraquinone compounds were successfully isolated, purified and tested for both in-silico and in-vitro analyses. Based on the in-silico prediction, two anthraquinones, morindone and rubiadin, exhibit a comparable binding affinity towards multitargets of β-catenin, MDM2-p53 and KRAS. Subsequently, we constructed a 2D interaction analysis based on the above results and it suggests that the predicted anthraquinones from Morinda citrifolia offer an attractive starting point for potential antiproliferative agents against colorectal cancer. In vitro analyses further indicated that morindone and damnacanthal have significant cytotoxicity effect and selectivity activity against colorectal cancer cell lines.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0270970
DOI:
10.1371/journal.pone.0270970.g001
DOI:
10.1371/journal.pone.0270970.g002
DOI:
10.1371/journal.pone.0270970.g003
DOI:
10.1371/journal.pone.0270970.g004
DOI:
10.1371/journal.pone.0270970.g005
DOI:
10.1371/journal.pone.0270970.g006
DOI:
10.1371/journal.pone.0270970.g007
DOI:
10.1371/journal.pone.0270970.g008
DOI:
10.1371/journal.pone.0270970.t001
DOI:
10.1371/journal.pone.0270970.t002
DOI:
10.1371/journal.pone.0270970.t003
DOI:
10.1371/journal.pone.0270970.t004
DOI:
10.1371/journal.pone.0270970.s001
DOI:
10.1371/journal.pone.0270970.s002
DOI:
10.1371/journal.pone.0270970.s003
DOI:
10.1371/journal.pone.0270970.s004
DOI:
10.1371/journal.pone.0270970.s005
DOI:
10.1371/journal.pone.0270970.s006
DOI:
10.1371/journal.pone.0270970.r001
DOI:
10.1371/journal.pone.0270970.r002
DOI:
10.1371/journal.pone.0270970.r003
DOI:
10.1371/journal.pone.0270970.r004
DOI:
10.1371/journal.pone.0270970.r005
DOI:
10.1371/journal.pone.0270970.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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