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  • 1
    Online Resource
    Online Resource
    Anticancer and antimicrobial potential of enterocin 12a from Enterococcus faecium
    Springer Science and Business Media LLC ; 2021
    In:  BMC Microbiology Vol. 21, No. 1 ( 2021-02-04)
    Details
    In: BMC Microbiology, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-02-04)
    Abstract: Increase in the number of infections caused by Gram-negative bacteria in neutropenic cancer patients has prompted the search for novel therapeutic agents having dual anticancer and antimicrobial properties. Bacteriocins are cationic proteins of prokaryotic origin that have emerged as one of the most promising alternative antimicrobial agents with applications as food preservatives and therapeutic agents. Apart from their antimicrobial activities, bacteriocins are also being explored for their anticancer potential. Results In this study, a broad-spectrum, cell membrane-permeabilizing enterocin with a molecular weight of 65 kDa was purified and characterized from the culture supernatant of vaginal Enterococcus faecium 12a. Enterocin 12a inhibited multidrug-resistant strains of various Gram-negative pathogens such as Salmonella enterica , Shigella flexneri , Vibrio cholerae , Escherichia coli and Gram-positive, Listeria monocytogenes, but had no activities against different strains of gut lactobacilli. The mass spectrometric analysis showed that the enterocin 12a shared partial homology with 4Fe-4S domain-containing redox protein of E. faecalis R712. Further, enterocin 12a selectively inhibited the proliferation of various human cancer cell lines in a dose-dependent manner but not that of normal human peripheral blood mononuclear cells. Enterocin 12a-treated cancer cells showed apoptosis-like morphological changes. Conclusion Enterocin 12a is a novel bacteriocin that has anticancer properties against human cell lines and negligible activity towards non-malignant cells. Therefore, it should be further evaluated for its anticancer potential in animal models.
    Type of Medium: Online Resource
    ISSN: 1471-2180
    URL: Article
    DOI: 10.1186/s12866-021-02086-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2041505-9
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Study and analysis of maternal serum alpha-fetoprotein levels as a biomarker of placental adherence in low lying placenta
    Medip Academy ; 2023
    In:  International Journal of Research in Medical Sciences Vol. 11, No. 5 ( 2023-04-29), p. 1704-1708
    Details
    In: International Journal of Research in Medical Sciences, Medip Academy, Vol. 11, No. 5 ( 2023-04-29), p. 1704-1708
    Abstract: Background: The objective was to study and analyze maternal serum alpha-fetoprotein levels as a biomarker of placental adherence in low lying placenta. Methods: This was a prospective observational study analysing the conditions and the data of 80 cases with low lying placenta in a tertiary care hospital. The analysis was done for the association of MSAFP with MRI, perinatal and maternal outcome. Results: The level of MSAFP was found higher in 12 out of 13 cases (93.3%) of placenta previa with placental adherence. There was significant surgical intervention (80%) and increased maternal morbidity (68.8%) in the study group with placental adherence and raised MSAFP respectively. Conclusions: MSAFP is an important biomarker for prognostication of placental adherence in low lying placenta.
    Type of Medium: Online Resource
    ISSN: 2320-6012 , 2320-6071
    URL: Article
    DOI: 10.18203/2320-6012.ijrms20231340
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Correlation of Vitamin D status with TSH levels in postmenopausal women; A pilot study
    IP Innovative Publication Pvt Ltd ; 2023
    In:  Annals of Geriatric Education and Medical Sciences Vol. 10, No. 1 ( 2023-8-28), p. 26-29
    Details
    In: Annals of Geriatric Education and Medical Sciences, IP Innovative Publication Pvt Ltd, Vol. 10, No. 1 ( 2023-8-28), p. 26-29
    Abstract: Vitamin D (VitD) insufficiency is present in over half of population worldwide. Over a billion people worldwide are vitamin D deficient or insufficient. It has been long known that VitD insufficiency contributes to development of osteopenia and osteoporosis. We performed a retrospective review of data of 60 patients in postmenopausal age group (45-75 years) during their routine blood investigation for the first time at Government Medical College and Guru Nanak Dev Hospital Amritsar over a period of 3 months (February 2023 to April 2023). Vitamin D levels were insufficient (10-30 ng/mL) in 35% of the patients, deficient (10 ng/mL) in 18.5%, and normal in the remaining 35%. TSH levels were low (less than 0.3 mIU/L) in 5%, high (more than 4.5 mIU/L) in 18.3%, and normal (0.3-4.5 mIU/L) in the remaining 76.6%. 54% (n-11) of individuals with elevated TSH had vitamin D deficiency, while 18% had insufficient vitamin D. 100%(n-3) patients with low TSH had normal vitamin D levels. TSH and vitamin D levels were normal in 22 individuals. High TSH levels was associated with low vitamin D levels, low TSH levels was associated with normal serum vitamin D level. Hence association was linear between TSH and vitamin D in post-menopausal women.
    Type of Medium: Online Resource
    ISSN: 2348-7348 , 2348-7240
    URL: Article
    DOI: 10.18231/j.agems.2023.007
    Language: Unknown
    Publisher: IP Innovative Publication Pvt Ltd
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Proteinaceous Secretory Metabolites of Probiotic Human Commensal Enterococcus hirae 20c, E. faecium 12a and L12b as Antiproliferative Agents Against Cancer Cell Lines
    Frontiers Media SA ; 2018
    In:  Frontiers in Microbiology Vol. 9 ( 2018-5-15)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 9 ( 2018-5-15)
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    DOI: 10.3389/fmicb.2018.00948
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2018
    detail.hit.zdb_id: 2587354-4
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  • 5
    Online Resource
    Online Resource
    Assessment of alpha glucosidase inhibitors produced from endophytic fungus Alternaria destruens as antimicrobial and antibiofilm agents
    Springer Science and Business Media LLC ; 2020
    In:  Molecular Biology Reports Vol. 47, No. 1 ( 2020-01), p. 423-432
    Details
    In: Molecular Biology Reports, Springer Science and Business Media LLC, Vol. 47, No. 1 ( 2020-01), p. 423-432
    Type of Medium: Online Resource
    ISSN: 0301-4851 , 1573-4978
    URL: Article
    DOI: 10.1007/s11033-019-05145-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 1478217-0
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Preliminary investigation of the effect of doping of copper oxide in CaO-SiO 2 -P 2 O 5 -MgO bioactive composition for bone repair applications
    Elsevier BV ; 2018
    In:  Materials Science and Engineering: C Vol. 83 ( 2018-02), p. 177-186
    Details
    In: Materials Science and Engineering: C, Elsevier BV, Vol. 83 ( 2018-02), p. 177-186
    Type of Medium: Online Resource
    ISSN: 0928-4931
    URL: Article
    DOI: 10.1016/j.msec.2017.09.006
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2012160-X
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  • 7
    Online Resource
    Online Resource
    An Overview on Oxidative Stress in Diabetes Mellitus
    Technoscience Academy ; 2022
    In:  International Journal of Scientific Research in Science and Technology
    Details
    In: International Journal of Scientific Research in Science and Technology, Technoscience Academy
    Abstract: Human body is continuously exposed to different types of agents that results in the production of reactive species called as free radicals (ROS/RNS) which by the transfer of their free unpaired electron causes the oxidation of cellular machinery. In order to encounter the deleterious effects of such species, body has got endogenous antioxidant systems or it obtains exogenous antioxidants from diet that neutralizes such species and keeps the homeostasis of body. Any imbalance between the RS and antioxidants leads to produce a condition known as ‘‘oxidative stress’’ that results in the development of pathological condition among which one is diabetes. Most of the studies reveal the inference of oxidative stress in diabetes pathogenesis by the alteration in enzymatic systems, lipid peroxidation, impaired Glutathione metabolism and decreased Vitamin C levels. Lipids, proteins, DNA damage, Glutathione, catalane and superoxide dismutase are various biomarkers of oxidative stress in diabetes mellitus. Oxidative stress induced complications of diabetes may include stroke, neuropathy, retinopathy and nephropathy. The basic aim of this review was to summarize the basics of oxidative stress in diabetes mellitus
    Type of Medium: Online Resource
    ISSN: 2395-602X , 2395-6011
    URL: Journal
    URL: Article
    DOI: 10.32628/IJSRST
    DOI: 10.32628/IJSRST229393
    Language: English
    Publisher: Technoscience Academy
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    A Comparative Study of Blood Glucose Level Measurement Between Glucometer and Semi Autoanalyser
    Technoscience Academy ; 2022
    In:  International Journal of Scientific Research in Science and Technology
    Details
    In: International Journal of Scientific Research in Science and Technology, Technoscience Academy
    Abstract: Background; Glucometers are the excellent tools for self-monitoring of blood glucose (SMBG). Glucometer is widely used at hospitals and homes as a first line tool to get an idea about the current blood glucose levels. They are important especially in the circumstances where continuous monitoring is mandatory and at decision making levels. Materials and Methods; The Study was Conducted in Department of Biochemistry, Civil Hospital Tarn Taran. Proper informed consent was taken from all the participation, a total of 60 sample were taken. Result; We found that that at very high glucose readings (i.e. in group 3 patients having plasma glucose levels ≥ 251 mg/dl), glucometer overestimates glucose results. So, these values do not accurately reflect actual plasma glucose levels. Conclusion; Blood glucose testing with glucometer is a simple, rapid & cost effective method for glucose monitoring. On the other hand centralized laboratory glucose testing despite higher operational time and cost burden is still more reliable method for diagnosis and management of the patient. Finding in our study suggest that very high glucose values with glucometer do not accurately reflect actual plasma glucose levels; but it overestimates glucose results. So, the routine practice of performing only single testing with glucometers can lead to misdiagnosis. So, readings obtained using glucometers especially at the critical hyperglycemic levels, should be cautiously interpreted and verified with centralized laboratory. Medical professionals should depict diabetic patients the importance of periodic centralized laboratory glucose testing. A further detailed study for comparison of plasma glucose levels using glucometer and GOD-POD method in hypoglycemic patients with a larger sample size is needed.
    Type of Medium: Online Resource
    ISSN: 2395-602X , 2395-6011
    URL: Journal
    URL: Article
    DOI: 10.32628/IJSRST
    DOI: 10.32628/IJSRST229590
    Language: English
    Publisher: Technoscience Academy
    Publication Date: 2022
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  • 9
    Online Resource
    Online Resource
    An endophytic Schizophyllum commune possessing antioxidant activity exhibits genoprotective and organprotective effects in fresh water fish Channa punctatus exposed to bisphenol A
    Springer Science and Business Media LLC ; 2022
    In:  BMC Microbiology Vol. 22, No. 1 ( 2022-12-06)
    Details
    In: BMC Microbiology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-12-06)
    Abstract: Oxidative stress is responsible for the onset of several chronic and degenerative diseases. Exogenous supply of antioxidants is reported to neutralize the effects of oxidative stress. Several synthetic antioxidants suffer from various side effects which necessitates the exploration of antioxidant compounds from natural sources. Endophytic fungi residing in the plants are gaining the attention of researchers as a source of novel antioxidants. Majority of the research conducted so far on endophytic fungi has been restricted to the members of phylum ascomycota. Basidiomycota, inspite of their immense bioactive potential remain relatively unexploited. This study aimed to assess the ameliorative effects of an endophytic Schizophyllum commune (basidiomycetous fungus) against oxidative stress associated altered antioxidant levels, genotoxicity and cellular damage to different organs in bisphenol A exposed fresh water fish Channa punctatus . Results Good antioxidant and genoprotective potential was exhibited by S. commune extract in in vitro studies conducted using different antioxidant, DNA damage protection, and cytokinesis blocked micronuclei assays. In vivo studies were performed in fresh water fish Channa punctatus exposed to bisphenol A. A significant decrease in the considered parameters for DNA damage (% micronuclei and comet assay) were recorded in fish treated with S. commune extract on comparison with untreated bisphenol A exposed group. The S. commune extract treated fish also exhibited an increase in the level of antioxidant enzymes viz . catalase, superoxide dismutase and glutathione reductase as well as histoprotective effect on various organs. GC-MS analysis revealed the presence of 3-n-propyl-2,4-pentanedione, n-heptadecanol-1, trans-geranylgeraniol, 3-ethyl-2-pentadecanone, 1-heneicosanol and squalene as some of the compounds in S. commune extract. Conclusion The study highlights the significance of an endophytic basidiomycetous fungus S. commune as a source of antioxidant compounds with possible therapeutic potential.
    Type of Medium: Online Resource
    ISSN: 1471-2180
    URL: Article
    DOI: 10.1186/s12866-022-02713-9
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041505-9
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  • 10
    Online Resource
    Online Resource
    A Comparative Study of Detection of Serum Total and Direct Bilirubin by Manual and Automated Methods
    Technoscience Academy ; 2022
    In:  International Journal of Scientific Research in Science and Technology
    Details
    In: International Journal of Scientific Research in Science and Technology, Technoscience Academy
    Abstract: Background: Bilirubin is one of the major bile Pigment, clinically and biologically important among the bile pigments present in the mammals. Material and Methods; The Cross sectional study was conducted in department of biochemistry in the collaboration with department medicine in Civil Hospital Tarn Taran. Out of 90 patients, 54 were males and 36 were females. Result; The comparison of Serum Total and Direct bilirubin by Jendrassik & Grof and Automated method was Non- Significant with p value = 0.7788 and 0.5394 respectively. The comparison of Serum Total and Direct bilirubin by Malloy Evelyn and Automated method is Highly Significant with p value =0.0002 and 0.0003 respectively. The mean difference of malloy with jendrassik & grof and automated was 2.394 and 2.162 respectively and the mean difference of jendrassik & grof with automated method was -0.231. Conclusion; It was concluded that a good correlation is found between bilirubin detection by manual and automated method. Non- significant mean difference between Jendrassik & Grof and Automated makes it better than Malloy Evelyn.
    Type of Medium: Online Resource
    ISSN: 2395-602X , 2395-6011
    URL: Journal
    URL: Article
    DOI: 10.32628/IJSRST
    DOI: 10.32628/IJSRST229395
    Language: English
    Publisher: Technoscience Academy
    Publication Date: 2022
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