In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 82, No. 1 ( 2021-01), p. 11-21
Abstract:
To determine the effects of dexmedetomidine, doxapram, and dexmedetomidine plus doxapram on ventilation ( e ), breath frequency, and tidal volume (V t ) in ball pythons ( Python regius ) and of doxapram on the thermal antinociceptive efficacy of dexmedetomidine. ANIMALS 14 ball pythons. PROCEDURES Respiratory effects of dexmedetomidine and doxapram were assessed with whole-body, closed-chamber plethysmography, which allowed for estimates of e and V t . In the first experiment of this study with a complete crossover design, snakes were injected, SC, with saline (0.9% NaCl) solution, dexmedetomidine (0.1 mg/kg), doxapram (10 mg/kg), or dexmedetomidine and doxapram, and breath frequency, e , and V t were measured before and every 30 minutes thereafter, through 240 minutes. In the second experiment, antinociceptive efficacy of saline solution, dexmedetomidine, and dexmedetomidine plus doxapram was assessed by measuring thermal withdrawal latencies before and 60 minutes after SC injection. RESULTS Dexmedetomidine significantly decreased breath frequency and increased V t but did not affect e at all time points, compared with baseline. Doxapram significantly increased e , breath frequency, and V t at 60 minutes after injection, compared with saline solution. The combination of dexmedetomidine and doxapram, compared with dexmedetomidine alone, significantly increased e at 30 and 60 minutes after injection and did not affect breath frequency and V t at all time points. Thermal withdrawal latencies significantly increased when snakes received dexmedetomidine or dexmedetomidine plus doxapram, versus saline solution. CONCLUSIONS AND CLINICAL RELEVANCE Concurrent administration of doxapram may mitigate the dexmedetomidine-induced reduction of breathing frequency without disrupting thermal antinociceptive efficacy in ball pythons.
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.82.1.11
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2021
detail.hit.zdb_id:
2056942-7
SSG:
22
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