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  • 1
    Online Resource
    Online Resource
    Nepal Journals Online (JOL) ; 1970
    In:  International Journal of Life Sciences Vol. 3 ( 1970-01-01)
    In: International Journal of Life Sciences, Nepal Journals Online (JOL), Vol. 3 ( 1970-01-01)
    Abstract: A novel protease from leaves of Choreospndias axillaris has been reported. C. axillaris, locally called Lapsi is dioceous, deciduous fruit - bearing large tree, having multiple daily uses. In an attempt to find method for determining sex of Lapsi at seedling stage , we stumbled upon a unique protease that has thwarted our effort to find sex - related protein. Thus protease is highly thermo - stable and acid resistant. Its preparation can be autoclaved without significant loss in activity. Its activity can be repeatedly precipitated by trichloroacetic acid. It possesses a Km value of 29 μM and Vmax 52.63 pmoles/min for bovine serum albumin as the substrate. It is catalytically so powerful that the level of soluble protein in leaf is below 20 μg per g dry weight. Lapsi leaf protease is an specific endopeptidase attacking peptide bonds that have phenylalanine, tyrosine, alanine and threonine / aspartic acid residues.  DOI: 10.3126/ijls.v3i0.2301
    Type of Medium: Online Resource
    ISSN: 2091-0525
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 1970
    detail.hit.zdb_id: 2722047-3
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  • 2
    Online Resource
    Online Resource
    Nepal Journals Online (JOL) ; 2023
    In:  Quest Journal of Management and Social Sciences Vol. 5, No. 1 ( 2023-07-13), p. 69-84
    In: Quest Journal of Management and Social Sciences, Nepal Journals Online (JOL), Vol. 5, No. 1 ( 2023-07-13), p. 69-84
    Abstract: Purpose: This study aims to examine the performance of five widely used technical indicators on Nepal Stock Exchange (NEPSE) indexes. Specifically, the study evaluates indicators such as the simple moving average, moving average convergence and divergence, relative strength index, stochastic oscillator, and Bollinger Band. Design/methodology/approach: The study utilizes a descriptive and quantitative research design. Daily closing index data of NEPSE and its six sub-indices are analyzed for a substantial period, ranging from 1st September 2012 to 31st August 2022. The performance of the technical indicators is examined through modeling, backtesting, and statistical analysis. The technical trading rules of each indicator are incorporated into the modeling process, and the results are analyzed using different performance metrics. Furthermore, the predictability of the indicators is tested through standard statistical analysis and bootstrap techniques utilizing a random walk model. Findings: The results of the study reveal that the technical strategies, as represented by the analyzed indicators, generally support the effectiveness of technical analysis in the NEPSE. However, the relative strength index stands out as an exception, generating negative returns. The second stage of the analysis indicates that the simple moving average, relative strength, and Bollinger band fail to generate significant returns in certain indices. The findings from the bootstrap techniques further contradict the forecasting ability of technical strategies in the NEPSE, raising questions about their real performance in the Nepalese stock market. Practical Implications: This research provides valuable insights for investors, traders, and market participants in understanding the nuances and limitations of technical analysis in the context of the NEPSE. The findings suggest that technical indicators, notably the relative strength index, should be interpreted cautiously and that investing decisions should take into account additional factors. The study contributes to the ongoing discussion on the effectiveness of technical analysis in the Nepalese stock market, assisting practitioners to make informed decisions and better understand market dynamics.
    Type of Medium: Online Resource
    ISSN: 2705-4535 , 2705-4527
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 2023
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  • 3
    In: International Journal of Pest Management, Informa UK Limited
    Type of Medium: Online Resource
    ISSN: 0967-0874 , 1366-5863
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2023
    detail.hit.zdb_id: 1490770-7
    SSG: 12
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  • 4
    In: Case Reports in Pathology, Hindawi Limited, Vol. 2022 ( 2022-5-17), p. 1-5
    Abstract: Lymphangioma is a benign tumor characterized by proliferation of thin-walled lymphatic spaces. Lymphangioma of the small-bowel mesentery is rare, with an incidence of 1 : 250,000, representing less than 1% of all lymphangiomas. The predilection of the tumor is in the head and neck (70%), axillary (20%), and internal organs (10%). They are usually asymptomatic but can cause acute abdominal symptoms due to complications such as volvulus, bleeding, or lymphangioma rupture that require emergent surgery. Here, we report a case of mesenteric lymphangioma (ML) of a small bowel in a paediatric patient who presented with pain abdomen on and off which increased in severity and later had features of subacute intestinal obstruction. He underwent explorative laparotomy, and the mass was excised completely along with the part of small intestine. Pathological analysis of the surgical specimen confirmed the diagnosis of ML of the small intestine. The postoperative recovery was uneventful, and the patient was discharged after ten days of hospital stay. Though benign in nature, ML may cause acute abdominal symptoms that require emergent surgery. Therefore, it has to be kept in differential diagnosis of the acute abdominal condition.
    Type of Medium: Online Resource
    ISSN: 2090-679X , 2090-6781
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2648758-5
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  • 5
    In: Cureus, Springer Science and Business Media LLC
    Type of Medium: Online Resource
    ISSN: 2168-8184
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2747273-5
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  • 6
    Online Resource
    Online Resource
    Nepal Journals Online (JOL) ; 2020
    In:  Journal of Universal College of Medical Sciences Vol. 8, No. 02 ( 2020-12-31), p. 25-30
    In: Journal of Universal College of Medical Sciences, Nepal Journals Online (JOL), Vol. 8, No. 02 ( 2020-12-31), p. 25-30
    Abstract: INTRODUCTION Stature is the important parameter along with age, sex and race while identifying bodies. Stature has direct relationship with the skeletal dimensions most importantly with lower limbs. This study attempts to derive regression equation (RE) and multiplication factor (MF) from femur length (FL) which could be used for stature reconstruction. MATERIAL AND METHODS The study was conducted amongst the 160 students and staff of Dhulikhel Hospital, Nepal for the period of six months from February 2020 to July 2020. The sample was composed of 95 males and 65 females between the age of 18 - 40 years. The femoral length and height was measured in standard position using standard measuring instruments. Statistical analysis was done using SPSS 25.   RESULTS The mean height and femur length of overall sample was 162.33 ±7.62 cm and 40.14 ±2.132 cm respectively, male surpassing the female dimensions. There was a strong correlation between femur length and stature (r = 0.723, 0.869 and 0.791 for males, females, and overall participants respectively). MF was derived as 4.084 ±0.139, 3.99 ±0.11, 4.047 ±0.135 and RE was derived as y = 75.51 + 2.13*FL ±4.06, y = 55.238 + 2.581*FL ±2.999, y = 48.791 + 2.829*FL ±4.672 for males, females and overall participants. Both methods were checked for accuracy and could successfully interpret the height (p 〉 0.05). CONCLUSION The femoral length was found to be a reliable estimator of stature of an individual by using both RE and MF.
    Type of Medium: Online Resource
    ISSN: 2350-8582 , 2091-2846
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 2020
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  • 7
    Online Resource
    Online Resource
    Nepal Journals Online (JOL) ; 2021
    In:  Journal of Gandaki Medical College-Nepal Vol. 14, No. 1 ( 2021-07-03), p. 14-18
    In: Journal of Gandaki Medical College-Nepal, Nepal Journals Online (JOL), Vol. 14, No. 1 ( 2021-07-03), p. 14-18
    Abstract: Introduction: Colorectal cancer is the most common malignancy of the gastrointestinal tract. They are common after 50 years of age and present with bleeding per rectum, altered bowel habits, anemia, pain abdomen, and weight loss. The objective of this study was to evaluate the demographic profile, clinical presentation, colonoscopy and histopathology findings of colorectal cancer. Methods: A descriptive cross-sectional study was conducted. Cases were studied from the departmental records. Clinical presentation, CT abdomen, colonoscopy, and histopathology findings of colorectal carcinoma were studied. Data entry was done in SPSS version 20. Results: The mean age of subjects was 56 ± 11.42 years (range of 34 – 80 years) with male predominance (M: F=3:2). Changes in bowel habits (92.3%), chronic abdominal pain (84.6%), generalized weakness (80.7%), rectal bleeding (46.2%), and significant weight loss (42.3%) were the most common presenting symptoms. Rectal carcinoma was the most common (35%) followed by carcinomas of ascending colon (14%) and descending colon (10 %). The most common morphology was proliferative growth (61.5%). All colorectal carcinomas were adenocarcinoma, and the majority was moderately differentiated (51.9%). Conclusion: Colorectal cancers are seen above 50 years of age and common in males. Changes in bowel habits, chronic abdominal pain, generalized weakness, rectal bleeding, and weight loss are the most common form of presentations. These patients usually present late with advanced disease and unfavorable histopathology. Screening colonoscopy 〉 50 years is strongly recommended.
    Type of Medium: Online Resource
    ISSN: 2070-4259 , 2070-4240
    Language: Unknown
    Publisher: Nepal Journals Online (JOL)
    Publication Date: 2021
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  • 8
    In: EMBO reports, EMBO, Vol. 24, No. 12 ( 2023-12-06)
    Abstract: image The structure of the heterotetrameric TRAP complex reveals the mode of interaction with the ribosome and the Sec61 protein translocation channel. Molecular dynamics simulations suggest that Sec61/TRAP induce membrane thinning, which stabilizes an open conformation of the Sec61 lateral gate. Cryo‐EM model of the ribosome/Sec61/TRAP protein translocon. Disrupting key TRAP interactions leads to defective insulin biogenesis. Ribosome anchoring of Sec61/TRAP remodels the ER membrane. Lateral gate conformation is modulated by the local membrane environment.
    Type of Medium: Online Resource
    ISSN: 1469-221X , 1469-3178
    Language: English
    Publisher: EMBO
    Publication Date: 2023
    detail.hit.zdb_id: 2025376-X
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    International Union of Crystallography (IUCr) ; 2022
    In:  Acta Crystallographica Section F Structural Biology Communications Vol. 78, No. 1 ( 2022-01-01), p. 39-44
    In: Acta Crystallographica Section F Structural Biology Communications, International Union of Crystallography (IUCr), Vol. 78, No. 1 ( 2022-01-01), p. 39-44
    Abstract: Synaptic adhesion molecules are major organizers of the neuronal network and play a crucial role in the regulation of synapse development and maintenance in the brain. Synaptic adhesion-like molecules (SALMs) and leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-PTPs) are adhesion protein families with established synaptic function. Dysfunction of several synaptic adhesion molecules has been linked to cognitive disorders such as autism spectrum disorders and schizophrenia. A recent study of the binding and complex structure of SALM3 and PTPσ using small-angle X-ray scattering revealed a 2:2 complex similar to that observed for the interaction of human SALM5 and PTPδ. However, the molecular structure of the SALM3–PTPσ complex remains to be determined beyond the small-angle X-ray scattering model. Here, the expression, purification, crystallization and initial 6.5 Å resolution structure of the mouse SALM3–PTPσ complex are reported, which further verifies the formation of a 2:2 trans-heterotetrameric complex similar to the crystal structure of human SALM5–PTPδ and validates the architecture of the previously reported small-angle scattering-based solution structure of the SALM3–PTPσ complex. Details of the protein expression and purification, crystal optimization trials, and the initial structure solution and data analysis are provided.
    Type of Medium: Online Resource
    ISSN: 2053-230X
    Language: Unknown
    Publisher: International Union of Crystallography (IUCr)
    Publication Date: 2022
    detail.hit.zdb_id: 2175956-X
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  • 10
    In: IDCases, Elsevier BV, Vol. 30 ( 2022), p. e01621-
    Type of Medium: Online Resource
    ISSN: 2214-2509
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2745454-X
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