In:
International Journal of Cancer, Wiley, Vol. 141, No. 12 ( 2017-12-15), p. 2505-2516
Abstract:
What's new? The dismal prognosis of pancreatic cancer has prompted investigation of alternative therapeutic avenues, one of which is the use of oncolytic viruses, which target cancer cells, proliferating specifically within them. Here, orthotopic implantation of two different pancreatic cancer cell lines (DT6606PDA and Panc02) in mice was used to evaluate immune activation following infection with Newcastle disease virus (NDV). While NDV successfully prompted an antitumor immune response in DT6606PDA tumors, initial tumor shrinkage in Panc02 mice was overtaken by relapse. The findings in DT6606PDA tumors suggest that direct oncolysis is followed by an adaptive immune response critical for long‐term tumor rejection.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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