In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-09-13)
Abstract:
Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Müller glial cells. We used human retinal epithelial cells to show that lactate can suppress consumption of glucose by the retinal pigment epithelium. Suppression of glucose consumption in the retinal pigment epithelium can increase the amount of glucose that reaches the retina. This framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.28899.001
DOI:
10.7554/eLife.28899.002
DOI:
10.7554/eLife.28899.003
DOI:
10.7554/eLife.28899.004
DOI:
10.7554/eLife.28899.005
DOI:
10.7554/eLife.28899.006
DOI:
10.7554/eLife.28899.007
DOI:
10.7554/eLife.28899.008
DOI:
10.7554/eLife.28899.009
DOI:
10.7554/eLife.28899.010
DOI:
10.7554/eLife.28899.011
DOI:
10.7554/eLife.28899.012
DOI:
10.7554/eLife.28899.013
DOI:
10.7554/eLife.28899.014
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3
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