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  • 1
    Online Resource
    Online Resource
    Screening Support System Based on Patient Survey Data—Case Study on Classification of Initial, Locally Collected COVID-19 Data
    MDPI AG ; 2021
    In:  Applied Sciences Vol. 11, No. 22 ( 2021-11-15), p. 10790-
    Details
    In: Applied Sciences, MDPI AG, Vol. 11, No. 22 ( 2021-11-15), p. 10790-
    Abstract: New diseases constantly endanger the lives of populations, and, nowadays, they can spread easily and constitute a global threat. The COVID-19 pandemic has shown that the fight against a new disease may be difficult, especially at the initial stage of the epidemic, when medical knowledge is not complete and the symptoms are ambiguous. The use of machine learning tools can help to filter out those sick patients who do not need to be tested for spreading the pathogen, especially in the event of an overwhelming increase in disease transmission. This work presents a screening support system that can precisely identify patients who do not carry the disease. The decision of the system is made on the basis of patient survey data that are easy to collect. A case study on a data set of symptomatic COVID-19 patients shows that the system can be effective in the initial phase of the epidemic. The case study presents an analysis of two classifiers that were tuned to achieve an assumed acceptable threshold of negative predictive values during classification. Additionally, an explanation of the obtained classification models is presented. The explanation enables the users to understand the basis of the decision made by the model. The obtained classification models provide the basis for the DECODE service, which could serve as support in screening patients with COVID-19 disease at the initial stage of the pandemic. Moreover, the data set constituting the basis for the analyses performed is made available to the research community. This data set, consisting of more than 3000 examples, is based on questionnaires collected at a hospital in Poland.
    Type of Medium: Online Resource
    ISSN: 2076-3417
    URL: Article
    DOI: 10.3390/app112210790
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2704225-X
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  • 2
    Online Resource
    Online Resource
    Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review
    OMICS Publishing Group ; 2017
    In:  Alternative & Integrative Medicine Vol. 06, No. 02 ( 2017)
    Details
    In: Alternative & Integrative Medicine, OMICS Publishing Group, Vol. 06, No. 02 ( 2017)
    Type of Medium: Online Resource
    ISSN: 2327-5162
    URL: Journal
    URL: Article
    DOI: 10.4172/2327-5162
    DOI: 10.4172/2327-5162.1000238
    Language: Unknown
    Publisher: OMICS Publishing Group
    Publication Date: 2017
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  • 3
    Online Resource
    Online Resource
    Symptom-based early-stage differentiation between SARS-CoV-2 versus other respiratory tract infections—Upper Silesia pilot study
    Springer Science and Business Media LLC ; 2021
    In:  Scientific Reports Vol. 11, No. 1 ( 2021-06-30)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-06-30)
    Abstract: In the DECODE project, data were collected from 3,114 surveys filled by symptomatic patients RT-qPCR tested for SARS-CoV-2 in a single university centre in March-September 2020. The population demonstrated balanced sex and age with 759 SARS-CoV-2( +) patients. The most discriminative symptoms in SARS-CoV-2( +) patients at early infection stage were loss of taste/smell (OR = 3.33, p   〈  0.0001), body temperature above 38℃ (OR = 1.67, p   〈  0.0001), muscle aches (OR = 1.30, p  = 0.0242), headache (OR = 1.27, p  = 0.0405), cough (OR = 1.26, p  = 0.0477). Dyspnea was more often reported among SARS-CoV-2(-) (OR = 0.55, p   〈  0.0001). Cough and dyspnea were 3.5 times more frequent among SARS-CoV-2(-) (OR = 0.28, p   〈  0.0001). Co-occurrence of cough, muscle aches, headache, loss of taste/smell (OR = 4.72, p  = 0.0015) appeared significant, although co-occurrence of two symptoms only, cough and loss of smell or taste, means OR = 2.49 ( p   〈  0.0001). Temperature  〉  38℃ with cough was most frequent in men (20%), while loss of taste/smell with cough in women (17%). For younger people, taste/smell impairment is sufficient to characterise infection, whereas in older patients co-occurrence of fever and cough is necessary. The presented study objectifies the single symptoms and interactions significance in COVID-19 diagnoses and demonstrates diverse symptomatology in patient groups.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-021-93046-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 4
    Online Resource
    Online Resource
    role of glymphatic system in neurological diseases - literature review
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2023
    In:  Journal of Education, Health and Sport Vol. 19, No. 1 ( 2023-09-19), p. 129-140
    Details
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 19, No. 1 ( 2023-09-19), p. 129-140
    Abstract: Abstract  Introduction: The glymphatic system is the equivalent of the lymphatic system in the brain. This system is responsible for the exchange of metabolism waste products between the cerebrospinal fluid and the interstitial fluid. The glymphatic system functions mainly during sleep, and this is when the removal of interstitial metabolism waste products take place. A proper diet and physical activity are also needed for the glymphatic system to work effectively. Abnormal function of the glymphatic system can contribute to the development of diseases of the central nervous system, including neurodegenerative diseases and migraine.  Aim of the study: The aim of our study is to review the latest knowledge linking the glymphatic system with the pathogenesis of selected neurological diseases and other lifestyle-related factors such as sleep, diet and physical activity. The study included Alzheimer’s disease, Parkinson’s disease, migraines and ischemic stroke.  Materials and methods: We have reviewed the literature available in the pubmed database using keywords: “glymphatic system”; “aquaporin-4”; “Alzheimer’s disease”; “Parkinson’s disease”; “migraines”; “sleep”  Conclusions: The studies discussed here show a clear correlation between the glymphatic system and neurological diseases. The glymphatic system may definitely be involved in the pathophysiology of neurological disorders. A thorough investigation of this issue will help uncover potentially new strategies for the prevention and treatment of neurological diseases.    Key words: glymphatic system; aquaporin-4; Alzheimer’s disease; Parkinson’s disease; migraine; sleep 
    Type of Medium: Online Resource
    ISSN: 2391-8306
    URL: Article
    DOI: 10.12775/JEHS.2023.19.01.013
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2023
    detail.hit.zdb_id: 2842726-9
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  • 5
    Online Resource
    Online Resource
    FDA Approves Omaveloxolone based on Successful Moxie Trial Results for Friedreich's Ataxia - Review
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2023
    In:  Journal of Education, Health and Sport Vol. 40, No. 1 ( 2023-08-08), p. 111-126
    Details
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 40, No. 1 ( 2023-08-08), p. 111-126
    Abstract: Introduction: In recent years, the medical community has witnessed a significant breakthrough in the treatment of Friedreich's Ataxia (FRDA), a rare and debilitating genetic disorder affecting the nervous system. This neurological condition, characterized by progressive muscle weakness, impaired coordination, and cardiomyopathy, has long posed challenges for both patients and healthcare professionals alike. However, there is newfound hope with the recent approval of Omaveloxolone by the U.S. Food and Drug Administration (FDA).Aim of the study: This review article aims to present a detailed summary of the FDA's approval of Omaveloxolone as a therapeutic option for Friedreich's Ataxia (FRDA), focusing on the positive results obtained from the MOXIe trial. It covers various aspects of FRDA and explains how Omaveloxolone works as an activator of NRF2, a transcription factor that helps reduce oxidative stress. The MOXIe trial, which examined the safety and effectiveness of Omaveloxolone in FRDA patients, is discussed in detail, including its methodology, primary and secondary goals, and results. Materials and methods: This review was based on available data collected in the PubMed and Google Scholar database, using the key words: FRDA, Friedreich’s Ataxia, Omaveloxolone, RTA 408, NRF2, MOXIe trail.Conclusion: Omaveloxolone has shown significant efficacy in improving neurological function and mFARS scores compared to a placebo in the MOXIe trial. It is well-tolerated with minimal adverse events. Early intervention with Omaveloxolone offers enhanced benefits for managing Friedreich's ataxia progression.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    URL: Article
    DOI: 10.12775/JEHS.2023.40.01.010
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2023
    detail.hit.zdb_id: 2842726-9
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  • 6
    Online Resource
    Online Resource
    Seborrheic dermatitis - pathogenesis, epidemiology and effective treatment - literature review
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2023
    In:  Journal of Education, Health and Sport Vol. 38, No. 1 ( 2023-10-04), p. 230-245
    Details
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 38, No. 1 ( 2023-10-04), p. 230-245
    Abstract: Introduction: Seborrheic dermatitis (SD) is common inflammatory dermatology disease. It’s affect up to 3-8% of the population. SD is characterized by erythema yellowish plaques and different level of itching and scaling. The last two symptoms are important factors that affect the quality of life of patients. This condition is usually a reaction to growth of  Malassezia spp and commonly develop in regions of strong sebaceous glands such as the scalp, facial area, chest, back. Other factors include increased activity of sebaceous glands, immunosuppression, and stress. Aim of the study: A review of current stage of knowledge on the pathophysiology, epidemiology of Seborrheic Dermatitis. Recommended management with newest guidelines of this disease. The impact of the Covid-19 pandemic and the use of masks on the incidence of Seborrheic Dermatitis. Material and methods: This review was based on available data searched in the PubMed and Google Scholar by using key words: Seborrheic dermatitis, pathophysiology, epidemiology, diagnosis, treatment, clinical presentation, scalp, infant.  Conclusion: The Pathogenesis of Seborrheic dermatitis is not fully understood, the exact molecular process needs to be examined. SD is chronic disease with episode of remission and relapse of symptoms. Patients should be informed that ongoing maintenance treatment will be required. Treatment include topical antifungal (ketoconazole, Ciclopirox olamine, zinc pyrithione) and topical anti-inflammatory drugs like mild or mid-strength corticosteroids or calcineurin inhibitors (off-label use). In severe or resistance cases systematic therapy could be necessary. In this situation antifungal drugs (terbinafine, itraconazole) or low dose of isotretinoin are available options. Also new synergic treatments were introduce like cannabinoids or vitamin D which could make therapy more efficiency.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    URL: Article
    DOI: 10.12775/JEHS.2023.38.01.016
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2023
    detail.hit.zdb_id: 2842726-9
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  • 7
    Online Resource
    Online Resource
    KRASG12C inhibitors in lung cancer therapy
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2023
    In:  Journal of Education, Health and Sport Vol. 17, No. 1 ( 2023-09-09), p. 165-177
    Details
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 17, No. 1 ( 2023-09-09), p. 165-177
    Abstract: Introduction: Lung cancer is characterized by the highest mortality among cancers and is the second most frequently diagnosed type of cancer in the world. Targeted therapies are a promising therapeutic option for patients with this disease, however, one of the most common and most malignant mutations (KRAS) remains a challenge. Purpose: The aim of this study is to bring closer the problem of the KRAS mutation, in particular KRASG12C, and to present the most important information about the compounds created for therapies targeted at it.For a better understanding of the issue, the study contains information about the mechanisms of both mutation and drugs, as well as the most important statistical data and research results. Materials and methods: The review was based on articles available in the PubMed database. Conclusions: Two drugs targeting KRASG12C (sotorasib and adagrasib) have proven their clinical effectiveness and represent a milestone in the development of targeted therapies for lung cancer with this mutation. However, they are not without side effects, and the emerging resistance and presence of commutations that reduce drug potency continue to challenge the scientific community. Research is underway to refine therapies using existing inhibitors as well as to develop further compounds targeting KRASG12C.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    URL: Article
    DOI: 10.12775/JEHS.2023.17.01.015
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2023
    detail.hit.zdb_id: 2842726-9
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  • 8
    Online Resource
    Online Resource
    Pruritus. Pathomechanism, management and novel treatment
    Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University ; 2023
    In:  Journal of Education, Health and Sport Vol. 17, No. 1 ( 2023-09-10), p. 134-152
    Details
    In: Journal of Education, Health and Sport, Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University, Vol. 17, No. 1 ( 2023-09-10), p. 134-152
    Abstract: Introduction Itching is an unpleasant sensation that is commonly experienced in the general population. It accompanies many diseases. This sensory experience is burdensome and significantly reduces the quality of life. The mechanism of itching is complex. It involves receptors, the histaminergic and non-histaminergic pathways, cytokines, neuropeptides, neurotransmitters, proteases, and enzymes. External factors such as temperature or capsaicin also influence itching. Aim of the study This review presents the current state of knowledge regarding therapy in the treatment of itching. Also aims to show that it is a complicated process. Pruritus is a very bothersome sensory sensation and is a common symptom.  Material and methods This review was based on scientific books on human physiology and dermatology were used, which are listed in the bibliography and available data collected in the PubMed and Google Scholar database. Using key words:  itch, management, pathogenesis, pathophysiology, pruritus, therapeutics, treatments. Conclusion The latest research on itching has led to a better understanding of this complex mechanism. As a result, there is a possibility of discovering new, innovative treatment methods that are targeted at specific elements of this process or work systemically. Understanding the broad etiology assists in identifying the cause and in implementing an appropriate therapeutic strategy. Further research will enable improvements in treatment and enhance patient comfort.
    Type of Medium: Online Resource
    ISSN: 2391-8306
    URL: Article
    DOI: 10.12775/JEHS.2023.17.01.013
    Language: Unknown
    Publisher: Uniwersytet Mikolaja Kopernika/Nicolaus Copernicus University
    Publication Date: 2023
    detail.hit.zdb_id: 2842726-9
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  • 9
    Online Resource
    Online Resource
    Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality
    VM Media Group sp. z o.o ; 2021
    In:  Neurologia i Neurochirurgia Polska Vol. 55, No. 3 ( 2021-06-30), p. 314-321
    Details
    In: Neurologia i Neurochirurgia Polska, VM Media Group sp. z o.o, Vol. 55, No. 3 ( 2021-06-30), p. 314-321
    Type of Medium: Online Resource
    ISSN: 1897-4260 , 0028-3843
    URL: Article
    DOI: 10.5603/PJNNS.a2021.0039
    Language: Unknown
    Publisher: VM Media Group sp. z o.o
    Publication Date: 2021
    detail.hit.zdb_id: 2234602-8
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  • 10
    Online Resource
    Online Resource
    Diverse action of repeated corticosterone treatment on synaptic transmission, neuronal plasticity, and morphology in superficial and deep layers of the rat motor cortex
    Springer Science and Business Media LLC ; 2017
    In:  Pflügers Archiv - European Journal of Physiology Vol. 469, No. 11 ( 2017-11), p. 1519-1532
    Details
    In: Pflügers Archiv - European Journal of Physiology, Springer Science and Business Media LLC, Vol. 469, No. 11 ( 2017-11), p. 1519-1532
    Type of Medium: Online Resource
    ISSN: 0031-6768 , 1432-2013
    URL: Article
    DOI: 10.1007/s00424-017-2036-5
    RVK:
    WA 15000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 1463014-X
    SSG: 12
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