In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-01-26)
Abstract:
Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs) require YAP/TAZ to enter S-phase and, without them, fail to generate sufficient SCs for timely axon sorting. To differentiate, SCs require YAP/TAZ to upregulate Krox20 and, without them, completely fail to myelinate, resulting in severe peripheral neuropathy. Remarkably, in adulthood, nuclear YAP/TAZ are selectively expressed by myelinating SCs, and conditional ablation results in severe peripheral demyelination and mouse death. YAP/TAZ regulate both developmental and adult myelination by driving TEAD1 to activate Krox20. Therefore, YAP/TAZ are crucial for SCs to myelinate developing nerve and to maintain myelinated nerve in adulthood. Our study also provides a new insight into the role of nuclear YAP/TAZ in homeostatic maintenance of an adult tissue.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.20982.001
DOI:
10.7554/eLife.20982.002
DOI:
10.7554/eLife.20982.003
DOI:
10.7554/eLife.20982.004
DOI:
10.7554/eLife.20982.005
DOI:
10.7554/eLife.20982.006
DOI:
10.7554/eLife.20982.007
DOI:
10.7554/eLife.20982.008
DOI:
10.7554/eLife.20982.009
DOI:
10.7554/eLife.20982.010
DOI:
10.7554/eLife.20982.011
DOI:
10.7554/eLife.20982.012
DOI:
10.7554/eLife.20982.013
DOI:
10.7554/eLife.20982.014
DOI:
10.7554/eLife.20982.015
DOI:
10.7554/eLife.20982.016
DOI:
10.7554/eLife.20982.017
DOI:
10.7554/eLife.20982.018
DOI:
10.7554/eLife.20982.019
DOI:
10.7554/eLife.20982.020
DOI:
10.7554/eLife.20982.022
DOI:
10.7554/eLife.20982.023
DOI:
10.7554/eLife.20982.021
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3
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