In:
Organic & Biomolecular Chemistry, Royal Society of Chemistry (RSC), Vol. 19, No. 41 ( 2021), p. 8874-8885
Abstract:
Benzimidazo[2,1- a ]isoquinolin-6(5 H )-one constitutes a structurally unique class of tetracyclic N-heterocycles that are found throughout a myriad of biologically active natural products, pharmaceutical compounds, and functional materials. Various synthetic routes for the preparation of benzimidazo[2,1- a ]isoquinolin-6(5 H )-ones have been reported. In particular, the use of N -methacryloyl-2-phenylbenzoimidazoles to construct benzimidazo[2,1- a ]isoquinolin-6(5 H )-ones through various radical strategies have attracted widespread attention due to the versatility and simple preparation of raw materials, as well as the step-economy and mild reaction conditions. Using representative examples, we highlight significant progress in the synthesis of benzimidazo[2,1- a ]isoquinolin-6(5 H )-ones, including the selection of the catalytic system, substrate scope, mechanistic understanding, and applications. The contents of this review focus on the development of C -, S -, P -, and Si -centered radical addition–intramolecular cyclization strategies.
Type of Medium:
Online Resource
ISSN:
1477-0520
,
1477-0539
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2021
detail.hit.zdb_id:
2097583-1
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