In:
The EMBO Journal, EMBO, Vol. 33, No. 14 ( 2014-07-17), p. 1565-1581
Abstract:
image Reprogramming of fibroblasts into cardiomyocytes is inefficient. Adding miR‐133a to the reprogramming cocktail increases the efficiency of the process in both mouse and human fibroblasts. Mechanistically, miR‐133a directly down‐regulates Snai1, a critical activator of the fibroblast transcriptional signature. MiR‐133 is induced by reprogramming factors during cardiac differentiation of fibroblasts. Addition of miR‐133 to reprogramming factors strongly promotes cardiac differentiation from both mouse and human fibroblasts. MiR‐133 directly represses Snai1, a master gene of epithelial‐to‐mesenchymal transition. Snai1 suppression by miR‐133 silences fibroblast signatures and promotes direct cardiac differentiation in combination with the reprogramming factors.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201387605
Language:
English
Publisher:
EMBO
Publication Date:
2014
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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