In:
Journal of Applied Clinical Medical Physics, Wiley, Vol. 19, No. 6 ( 2018-11), p. 159-165
Abstract:
The purpose of this work was to compare dose distributions between two radiosurgery modalities, single‐isocenter volumetric modulated arc therapy ( VMAT ), and GammaKnife Perfexion ( GK ), in the treatment of a large number (≥7) of brain metastases. Twelve patients with 103 brain metastases were analyzed. The median number of targets per patient was 8 (range: 7–14). GK plans were compared to noncoplanar VMAT plans using both 6‐ MV flattening filter‐free ( FFF ) and 10‐ MV FFF modes. Parameters analyzed included radiation therapy oncology group conformity index ( CI ), 12, 6, and 3 Gy isodose volumes (V12 Gy, V6 Gy, V3 Gy), mean and maximum hippocampal dose, and maximum skin dose. There were statistically significant differences in CI (2.5 ± 1.6 vs 1.6 ± 0.8 and 1.7 ± 0.9, P 〈 0.001, P 〈 0.001), V12 Gy (2.8 ± 6.1 cc vs 3.0 ± 5.2 cc and 3.1 ± 5.4 cc, P = 0.003, P 〈 0.001), and V3 Gy (323.0 ± 294.8 cc vs, 880.1 ± 369.1 cc and 937.9 ± vs 361.9 cc, P = 0.005, P = 0.001) between GK versus both 6‐ MV FFF and 10‐ MV FFF . No significant differences existed for maximum hippocampal or skin doses. In conclusion, highly optimized VMAT produced improved conformity at the expense of a higher V12 Gy and V3 Gy volume when compared with highly optimized GK .
Type of Medium:
Online Resource
ISSN:
1526-9914
,
1526-9914
DOI:
10.1002/acm2.2018.19.issue-6
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2010347-5
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