In:
Current Neuropharmacology, Bentham Science Publishers Ltd., Vol. 20, No. 3 ( 2022-03), p. 476-493
Abstract:
The ability of the nervous system to detect a wide range of noxious stimuli is crucial to
avoid life-threatening injury and to trigger protective behavioral and physiological responses. Pain represents a complex phenomenon, including nociception associated with cognitive and emotional
processing. Animal experimental models have been developed to understand the mechanisms involved in pain response, as well as to discover novel pharmacological and non-pharmacological
anti-pain therapies. Due to the genetic tractability, similar physiology, low cost, and rich behavioral repertoire, the zebrafish (Danio rerio) is a powerful aquatic model for modeling pain responses.
Here, we summarize the molecular machinery of zebrafish responses to painful stimuli, as well as emphasize how zebrafish-based pain models have been successfully used to understand specific
molecular, physiological, and behavioral changes following different algogens and/or noxious stimuli (e.g., acetic acid, formalin, histamine, Complete Freund's Adjuvant, cinnamaldehyde, allyl
isothiocyanate, and fin clipping). We also discuss recent advances in zebrafish-based studies and outline the potential advantages and limitations of the existing models to examine the mechanisms
underlying pain responses from evolutionary and translational perspectives. Finally, we outline how zebrafish models can represent emergent tools to explore pain behaviors and pain-related mood
disorders, as well as to facilitate analgesic therapy screening in translational pain research.
Type of Medium:
Online Resource
ISSN:
1570-159X
DOI:
10.2174/1570159X19666210311104408
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2022
detail.hit.zdb_id:
2119376-9
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