In:
Ophthalmologica, S. Karger AG, Vol. 243, No. 3 ( 2020), p. 187-194
Abstract:
〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 Evaluation of 〈 i 〉 Complement Factor I (CFI) rs10033900 〈 /i 〉 and 〈 i 〉 rs2285714 〈 /i 〉 polymorphism frequencies in patients with age-related macular degeneration (AMD) and healthy controls in a Turkish population. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 111 eyes of 111 AMD patients and 96 eyes of 96 healthy controls, only one eye of individuals, were included in the study; however, 2 patients’ and 4 controls’ samples were excluded as analyses could not be performed for 〈 i 〉 rs10033900 〈 /i 〉 polymorphism. The AMD patients and control group ( & #x3e;50 years) lacked corneal, lenticular, vitreal opacity. However, these patients did not have any retinal diseases apart from AMD. Venous blood samples of patients were collected. Central macular thickness, subfoveal choroidal thickness (SCT), presence of reticular drusen, epiretinal membrane, and pigment epithelial detachment were investigated using Spectral-Domain Optical Coherence Tomography, and the largest diameter of atrophic areas measured. Drusen properties were documented from fundus photographs. The lesion width was calculated by using fundus fluorescein angiography. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There was no difference between patient and control groups and polymorphism distributions. The frequency of the 〈 i 〉 CT 〈 /i 〉 allele was higher in patients with dry-type AMD with retinal pigment epithelial abnormality ( 〈 i 〉 p 〈 /i 〉 = 0.041). SCT was significantly thinner in 〈 i 〉 TT 〈 /i 〉 allele carriers with 〈 i 〉 rs2285714 〈 /i 〉 polymorphism ( 〈 i 〉 p 〈 /i 〉 = 0.030). No significant relationship was found between the other parameters and polymorphism distributions. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 〈 i 〉 CFI 〈 /i 〉 〈 i 〉 rs10033900 〈 /i 〉 and 〈 i 〉 rs2285714 〈 /i 〉 polymorphisms in a Turkish population were not associated with AMD.
Type of Medium:
Online Resource
ISSN:
0030-3755
,
1423-0267
Language:
English
Publisher:
S. Karger AG
Publication Date:
2020
detail.hit.zdb_id:
1483531-9
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