In:
The Neuroscientist, SAGE Publications, Vol. 2, No. 1 ( 1996-01), p. 55-65
Abstract:
For more than a century, mesial cerebral structures have been candidate substrates for the mediation of emotional experience. Although limbic structures were originally conceived as forming a midline ring, emerging evidence suggests that emotional processes may be related more closely to anterior paralimbic (anterior limbic and nearby cortical) regions than to posterior limbic regions. In addition, basal ganglia-thalamocortical circuits for various cerebral processes have been proposed, including one involving anterior paralimbic structures thought to mediate emotion. Recent brain imaging studies have advanced this thesis by demonstrating anterior paralimbic activation during affective arousal in healthy volunteers. The overwhelming majority of functional imaging studies of both primary and secondary depression has demonstrated decreased anterior paralimbic and prefrontal cortical activity, the latter of which often correlated with severity of depression and resolved with symptom remission. A few studies have noted increased activity in these same regions, which may reflect heterogeneity due to particular illness subtypes. Preliminary evidence has suggested that baseline functional abnormalities in these structures may relate to diagnostic subtypes and provide differential markers of therapeutic responses. New imaging methods with greater sensitivity, spatial and temporal resolution, and biochemical specificity promise to fuel further insights into the neurobiology of normal emotion in health, subtypes of affective disorders, and perhaps even improved targeting of therapeutic interventions.
Type of Medium:
Online Resource
ISSN:
1073-8584
,
1089-4098
DOI:
10.1177/107385849600200113
Language:
English
Publisher:
SAGE Publications
Publication Date:
1996
detail.hit.zdb_id:
2029471-2
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