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  • 1
    Online Resource
    Online Resource
    Defining Medical AI Competencies for Medical School Graduates: Outcomes of a Delphi Survey and Medical Student/Educator Questionnaire of South Korean Medical Schools
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Academic Medicine Vol. 99, No. 5 ( 2024-5), p. 524-533
    Details
    In: Academic Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 99, No. 5 ( 2024-5), p. 524-533
    Abstract: Given the increasing significance and potential impact of artificial intelligence (AI) technology on health care delivery, there is an increasing demand to integrate AI into medical school curricula. This study aimed to define medical AI competencies and identify the essential competencies for medical graduates in South Korea. Method An initial Delphi survey conducted in 2022 involving 4 groups of medical AI experts (n = 28) yielded 42 competency items. Subsequently, an online questionnaire survey was carried out with 1,955 participants (1,174 students and 781 professors) from medical schools across South Korea, utilizing the list of 42 competencies developed from the first Delphi round. A subsequent Delphi survey was conducted with 33 medical educators from 21 medical schools to differentiate the essential AI competencies from the optional ones. Results The study identified 6 domains encompassing 36 AI competencies essential for medical graduates: (1) understanding digital health and changes driven by AI; (2) fundamental knowledge and skills in medical AI; (3) ethics and legal aspects in the use of medical AI; (4) medical AI application in clinical practice; (5) processing, analyzing, and evaluating medical data; and (6) research and development of medical AI, as well as subcompetencies within each domain. While numerous competencies within the first 4 domains were deemed essential, a higher percentage of experts indicated responses in the last 2 domains, data science and medical AI research and development, were optional. Conclusions This medical AI framework of 6 competencies and their subcompetencies for medical graduates exhibits promising potential for guiding the integration of AI into medical curricula. Further studies conducted in diverse contexts and countries are necessary to validate and confirm the applicability of these findings. Additional research is imperative for developing specific and feasible educational models to integrate these proposed competencies into pre-existing curricula.
    Type of Medium: Online Resource
    ISSN: 1040-2446
    URL: Article
    DOI: 10.1097/ACM.0000000000005618
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 2025367-9
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  • 2
    Online Resource
    Online Resource
    Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status
    Korean Diabetes Association ; 2021
    In:  Diabetes & Metabolism Journal Vol. 45, No. 1 ( 2021-01-31), p. 1-10
    Details
    In: Diabetes & Metabolism Journal, Korean Diabetes Association, Vol. 45, No. 1 ( 2021-01-31), p. 1-10
    Type of Medium: Online Resource
    ISSN: 2233-6079 , 2233-6087
    URL: Article
    DOI: 10.4093/dmj.2020.0254
    Language: English
    Publisher: Korean Diabetes Association
    Publication Date: 2021
    detail.hit.zdb_id: 2602402-0
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  • 3
    Online Resource
    Online Resource
    Comparative Analysis of the Suspected Heparin‐Induced Thrombocytopenia Level in Korea
    Wiley ; 2017
    In:  Basic & Clinical Pharmacology & Toxicology Vol. 121, No. 4 ( 2017-10), p. 360-367
    Details
    In: Basic & Clinical Pharmacology & Toxicology, Wiley, Vol. 121, No. 4 ( 2017-10), p. 360-367
    Abstract: The primary objective of our study was to evaluate the frequency of suspected heparin‐induced thrombocytopenia ( HIT ) among patients treated with different formulations of heparin and investigate the factors that affect the incidence of HIT . This study is an electronic medical record ( EMR )‐based large‐scale retrospective cohort study conducted from 2009 to 2014 in Korea. After hospitalization, patient platelet count was determined before heparin was prescribed, and all platelet count values obtained during hospitalization were extracted. Suspected HIT was estimated by three 4Ts scores (acute thrombocytopenia, timing onset and other possible causes), which when combined yielded a high probability of HIT . Among 6046 patients enrolled in this study, HIT was suspected in 641 cases (10.6%) and a statistically significant increase in HIT incidence rate was observed for three heparins used ( p 〈 0.001). Dalteparin ( HR = 0.55, p = 0.036) and enoxaparin ( HR = 0.40, p 〈 0.001) showed a relatively low HIT incidence rate, compared to unfractionated heparin. Majority of suspected HIT cases (76.9 and 66.7%) occurred in days 8–10 and 5–7 of dalteparin and enoxaparin treatments, respectively. Most of the patients medicated with dalteparin were cancer patients; however, no statistically significant relationship was observed between HIT occurrence and cancer. HIT can cause serious complications, making early diagnosis crucial. Clinical practitioners first prescribing heparin should focus on preventing and detecting complications early by conducting frequent, regular platelet counts before and after heparin administration.
    Type of Medium: Online Resource
    ISSN: 1742-7835 , 1742-7843
    URL: Issue
    URL: Article
    DOI: 10.1111/bcpt.2017.121.issue-4
    DOI: 10.1111/bcpt.12791
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2151592-X
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    The prevalence of GAD antibodies in Korean women with gestational diabetes mellitus and their clinical characteristics during and after pregnancy
    Wiley ; 2009
    In:  Diabetes/Metabolism Research and Reviews Vol. 25, No. 4 ( 2009-05), p. 329-334
    Details
    In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 25, No. 4 ( 2009-05), p. 329-334
    Type of Medium: Online Resource
    ISSN: 1520-7552 , 1520-7560
    URL: Issue
    URL: Article
    DOI: 10.1002/dmrr.v25:4
    DOI: 10.1002/dmrr.963
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2001565-3
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  • 5
    Online Resource
    Online Resource
    Mutation Screening of HNF-1α Gene in Korean Women with Gestational Diabetes Mellitus
    Korean Diabetes Association ; 2008
    In:  Korean Diabetes Journal Vol. 32, No. 1 ( 2008), p. 38-
    Details
    In: Korean Diabetes Journal, Korean Diabetes Association, Vol. 32, No. 1 ( 2008), p. 38-
    Type of Medium: Online Resource
    ISSN: 1976-9180
    URL: Article
    DOI: 10.4093/kdj.2008.32.1.38
    Language: Korean
    Publisher: Korean Diabetes Association
    Publication Date: 2008
    detail.hit.zdb_id: 2602402-0
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  • 6
    Online Resource
    Online Resource
    The Impact of the Association between Cancer and Diabetes Mellitus on Mortality
    MDPI AG ; 2022
    In:  Journal of Personalized Medicine Vol. 12, No. 7 ( 2022-07-01), p. 1099-
    Details
    In: Journal of Personalized Medicine, MDPI AG, Vol. 12, No. 7 ( 2022-07-01), p. 1099-
    Abstract: The prevalence of cancer, diabetes mellitus (DM), and hypertension is increasing in ageing populations. We analyzed the association of DM with cancer and its effects on cancer mortality. The data of 2009–2018 from the Korea National Hospital Discharge In-depth Injury Survey were used; 169,959 adults with cancer as the main diagnosis were identified. The association rule for unsupervised machine learning was used. Association rule mining was used to analyze the association between the diseases. Logistic regression was performed to determine the effects of DM on cancer mortality. DM prevalence was 12.9%. Cancers with high DM prevalence were pancreatic (29.9%), bile duct (22.7%), liver (21.4%), gallbladder (15.5%), and lung cancers (15.4%). Cancers with high hypertension prevalence were bile duct (31.4%), ureter (30.5%), kidney (29.5%), pancreatic (28.1%), and bladder cancers (27.5%). The bidirectional association between DM and hypertension in cancer was the strongest (lift = 2.629, interest support [IS] scale = 0.426), followed by that between lung cancer and hypertension (lift = 1.280, IS scale = 0.204), liver cancer and DM (lift = 1.658, IS scale = 0.204), hypertension and liver cancer and DM (lift = 3.363, IS scale = 0.197), colorectal cancer and hypertension (lift = 1.133, IS scale = 0.180), and gastric cancer and hypertension (lift = 1.072, IS scale = 0.175). DM increased liver cancer mortality (p = 0.000), while hypertension significantly increased the mortality rate of stomach, colorectal, liver, and lung cancers. Our study confirmed the association between cancer and DM. Consequently, a patient management strategy with presumptive diagnostic ability for DM and hypertension is required to decrease cancer mortality rates.
    Type of Medium: Online Resource
    ISSN: 2075-4426
    URL: Article
    DOI: 10.3390/jpm12071099
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662248-8
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  • 7
    Online Resource
    Online Resource
    Diabetic Peripheral Neuropathy Is Associated With Increased Arterial Stiffness Without Changes in Carotid Intima–Media Thickness in Type 2 Diabetes
    American Diabetes Association ; 2011
    In:  Diabetes Care Vol. 34, No. 6 ( 2011-06-01), p. 1403-1405
    Details
    In: Diabetes Care, American Diabetes Association, Vol. 34, No. 6 ( 2011-06-01), p. 1403-1405
    Abstract: This study was conducted to investigate the association of diabetic peripheral neuropathy (DPN) with both arterial stiffness and intima–media thickness (IMT). RESEARCH DESIGN AND METHODS We conducted a cross-sectional analysis of 731 subjects with type 2 diabetes. DPN was diagnosed on the basis of neuropathic symptoms, insensitivity to a 10-g monofilament, abnormal pin-prick sensation, and abnormal current perception threshold. Arterial stiffness was assessed by cardio-ankle vascular index (CAVI), and IMT was assessed by B-mode ultrasonography. RESULTS Patients with DPN had higher CAVI than those without DPN in multivariate-adjusted models, whereas no differences in IMT were observed between patients with and without DPN after adjustment for age and sex. In the multivariate analysis, CAVI was a significant determinant of DPN (odds ratio 1.36 [95% CI 1.13–1.65], P = 0.001). CONCLUSIONS DPN is significantly associated with arterial stiffness without carotid intimal changes in patients with type 2 diabetes.
    Type of Medium: Online Resource
    ISSN: 0149-5992 , 1935-5548
    URL: Article
    DOI: 10.2337/dc10-2222
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 2011
    detail.hit.zdb_id: 1490520-6
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  • 8
    Online Resource
    Online Resource
    Modeling of Changes in Creatine Kinase after HMG-CoA Reductase Inhibitor Prescription
    Korean Society of Cardiovascular Disease Prevention ; 2021
    In:  Cardiovascular Prevention and Pharmacotherapy Vol. 3, No. 4 ( 2021-10-31), p. 115-123
    Details
    In: Cardiovascular Prevention and Pharmacotherapy, Korean Society of Cardiovascular Disease Prevention, Vol. 3, No. 4 ( 2021-10-31), p. 115-123
    Abstract: Background: Statin-associated muscle symptoms are one of the side effects that physicians should consider when prescribing statins. In this study, creatine kinase (CK) levels were measured following statin prescription, and various factors affecting the CK levels were determined using machine learning.Methods: Changes in the CK were observed every 3 months for a 12-month period in patients who received statins for the first time at Seoul St. Mary's Hospital. For each visit, we developed four basic models based on changes in the CK levels. Extreme gradient boosting, a scalable end-to-end tree boosting algorithm, which employs a decision-tree-based ensemble machine learning algorithm, was used for the prediction of changes in the CK.Results: A total of 23,860 patients were included. Among them, 19 patients (0.08%) had increased CK levels of 2,000 IU·L 〈 sup 〉 −1 〈 /sup 〉 or more 3 months after statin prescription, and 65 patients (0.27%) exhibited CK levels of over 2,000 IU·L 〈 sup 〉 −1 〈 /sup 〉 at least once during the 12-month study period. The area under the receiver operator characteristic of each model for each visit was 0.709–0.769, and the accuracy was 0.700–0.803. In each of the models, the variables that had the strongest influence on changes in the CK were sex and previous CK value.Conclusions: Through machine learning, factors influencing changes in the CK were identified. These results will provide the basis for future research, through which the optimal parameters of the CK prediction model can be found and the model can be used in clinical applications.
    Type of Medium: Online Resource
    ISSN: 2671-700X
    URL: Article
    DOI: 10.36011/cpp.2021.3.e15
    Language: English
    Publisher: Korean Society of Cardiovascular Disease Prevention
    Publication Date: 2021
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  • 9
    Online Resource
    Online Resource
    811-P: Safety and Effectiveness of iGlarLixi in People with Type 2 Diabetes Mellitus (T2DM) in South Korea
    American Diabetes Association ; 2024
    In:  Diabetes Vol. 73, No. Supplement_1 ( 2024-06-14)
    Details
    In: Diabetes, American Diabetes Association, Vol. 73, No. Supplement_1 ( 2024-06-14)
    Abstract: Introduction & Objective: The fixed ratio combination of insulin glargine and lixisenatide, iGlarLixi, was indicated as antihyperglycemic for people with T2DM and approved in November 2017 in South Korea. This post marketing surveillance (PMS) study aimed to evaluate the safety and effectiveness of iGlarLixi in clinical practice setting. Methods: This study was a multicenter, prospective, single-arm, observational study conducted in Korean people with T2DM from August 2018 to August 2023. Primary endpoint was to investigate safety profile. Secondary endpoints included changes in HbA1c, FPG and 2-hour PPG from baseline to Week 12 and 24. Results: Out of 743 people enrolled, 625 were included in safety evaluation and 519 in effectiveness evaluation. The mean age was 60.9 years and duration of T2DM was 13.6 years with equal proportions of male and female participants. Adverse events (AEs) and adverse drug reactions (ADRs) were reported in 120 (19.2%, 163 events) and 51 (8.2%, 63 events) participants, respectively. Most common AEs were gastrointestinal disorders (6.7%) such as nausea, decreased appetite, and vomiting. Significant reductions in HbA1c, FPG, 2-hour PPG were observed from baseline to Weeks 12 and 24 (Table). Conclusion: In clinical practice, iGlarLixi has shown to be safe and well tolerated without new safety concerns improving clinical outcomes in people with T2DM in South Korea. Disclosure H. Kim: None. K. Min: None. S. Kim: None. E. Kim: None. Y. Chung: None. C.H. Chung: None. J. Yun: None. W. Kim: None. D. Kim: Employee; Sanofi, GlaxoSmithKline plc. S. Yoo: None. Funding Sanofi
    Type of Medium: Online Resource
    ISSN: 0012-1797
    URL: Article
    DOI: 10.2337/db24-811-P
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 2024
    detail.hit.zdb_id: 1501252-9
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  • 10
    Online Resource
    Online Resource
    Identifying genetic variants underlying medication-induced osteonecrosis of the jaw in cancer and osteoporosis: a case control study
    Springer Science and Business Media LLC ; 2019
    In:  Journal of Translational Medicine Vol. 17, No. 1 ( 2019-12)
    Details
    In: Journal of Translational Medicine, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2019-12)
    Abstract: Bisphosphonate-induced osteonecrosis of the jaw (BRONJ) presents with a typical pattern of jaw necrosis in patients who have been prescribed bisphosphonates (BPs) and other antiangiogenetic drugs to treat osteoporosis or bone-related complications of cancer. Methods This study divided 38 patients with BRONJ into two groups according to the prescribing causes: cancer ( n  = 13) and osteoporosis ( n  = 25), and underwent whole exome sequencing and compared them with normal controls ( n  = 90). To identify candidate genes and variants, we conducted three analyses: a traditional genetic model, gene-wise variant score burden, and rare-variant analysis methods. Results The stop-gain mutation (rs117889746) of the PZP gene in the BRONJ cancer group was significantly identified in the additive trend model analysis. In the cancer group, ARIDS , HEBP1 , LTBP1 , and PLVAP were identified as candidate genes. In the osteoporosis group, VEGFA , DFFA , and FAM193A genes showed a significant association. No significant genes were identified in the rare-variant analysis pipeline. Biologically accountable functions related to BRONJ occurrence-angiogenesis-related signaling ( VEGFA and PLVAP genes), TGF-β signaling ( LTBP1 and PZP genes), heme toxicity ( HEBP1 ) and osteoblast maturation ( ARIDS )-were shown in candidate genes. Conclusion This study showed that the candidate causative genes contributing to the development of BRONJ differ according to the BP dose and background disease.
    Type of Medium: Online Resource
    ISSN: 1479-5876
    URL: Article
    DOI: 10.1186/s12967-019-2129-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2118570-0
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