In:
Journal of Alzheimer's Disease, IOS Press, Vol. 91, No. 4 ( 2023-02-14), p. 1515-1525
Abstract:
Background: The fecal immunochemical test (FIT) is widely used in screening for colorectal cancer (CRC), but FIT results can be positive for diseases other than CRC. Objective: We investigated the association between positive results of FIT and the incidence of dementia using a nationwide database. Methods: FIT-positive participants were collected from a database provided by the Korean National Health Insurance Service. Results: The incidence of all kinds of dementia was higher in FIT-positive than FIT-negative subjects (p 〈 0.0001). FIT-positive participants had a higher risk of Alzheimer’s disease (AD) (p 〈 0.0001) and vascular dementia (p = 0.0002), compared to participants with FIT negativity. The risk of all kinds of dementia or AD in FIT-positive participants was higher in younger (age 〈 65 years) than older participants (p 〈 0.0001 for all kinds of dementia; p = 0.0002 for AD). Conclusion: FIT positivity was correlated with an increased risk of dementia, especially in participants under 65 years of age. The study suggests that clinicians can consider dementia when FIT-positive participants fail to show any malignancies.
Type of Medium:
Online Resource
ISSN:
1387-2877
,
1875-8908
Language:
Unknown
Publisher:
IOS Press
Publication Date:
2023
detail.hit.zdb_id:
2070772-1
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