In:
Biomolecular NMR Assignments, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2023-06), p. 135-142
Abstract:
The splicing isoform b of human fibroblast growth factor 8 (FGF8b) is an important regulator of brain embryonic development. Here, we report the almost complete NMR chemical shift assignment of the backbone and aliphatic side chains of FGF8b. Obtained chemical shifts are in good agreement with the previously reported X-ray data, excluding the N-terminal gN helix, which apparently forms only in complex with the receptor. The reported data provide an NMR starting point for the investigation of FGF8b interaction with its receptors and with potential drugs or inhibitors.
Type of Medium:
Online Resource
ISSN:
1874-2718
,
1874-270X
DOI:
10.1007/s12104-023-10132-8
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
2388861-1
Permalink