In:
TECHNOLOGY, World Scientific Pub Co Pte Ltd, Vol. 03, No. 04 ( 2015-12), p. 172-178
Abstract:
The most common positron emission tomography (PET) radio-labeled probe for molecular diagnostics in patient care and research is the glucose analog, 2-deoxy-2-[F-18]fluoro-D-glucose ( 18 F-FDG). We report on an integrated microfluidics-chip/beta particle imaging system for in vitro 18 F-FDG radioassays of glycolysis with single cell resolution. We investigated the kinetic responses of single glioblastoma cancer cells to targeted inhibitors of receptor tyrosine kinase signaling. Further, we find a weak positive correlation between cell size and rate of glycolysis.
Type of Medium:
Online Resource
ISSN:
2339-5478
,
2345-7740
DOI:
10.1142/S2339547815200058
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2015
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