In:
European Journal of Haematology, Wiley, Vol. 98, No. 5 ( 2017-05), p. 493-500
Abstract:
To ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry. Results Of the 3179 cytogenetically informative AMLs diagnosed January 1997‐May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18‐60 years vs. 23% at 〉 60 years; P 〈 .0001); the median age was 69 years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6 years) and IR groups (1.7 years; P =.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5 years for +4, 1.9 years for +21, 1.5 years for +8, 1.1 years for +11, and 0.8 years for +13 ( P =.013). Conclusion AML with single trisomies, with the exception of +13, should be grouped as IR.
Type of Medium:
Online Resource
ISSN:
0902-4441
,
1600-0609
DOI:
10.1111/ejh.2017.98.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2027114-1
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