In:
Vaccines, MDPI AG, Vol. 11, No. 3 ( 2023-02-22), p. 507-
Abstract:
mRNA vaccines take advantage of the mechanism that our cells use to produce proteins. Our cells produce proteins based on the knowledge contained in our DNA; each gene encodes a unique protein. The genetic information is essential, but cells cannot use it until mRNA molecules convert it into instructions for producing specific proteins. mRNA vaccinations provide ready-to-use mRNA instructions for constructing a specific protein. BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) both are newly approved mRNA-based COVID-19 vaccines that have shown excellent protection and efficacy. In total, there are five more mRNA-based vaccine candidates for COVID-19 under different phases of clinical development. This review is specifically focused on mRNA-based vaccines for COVID-19 covering its development, mechanism, and clinical aspects.
Type of Medium:
Online Resource
ISSN:
2076-393X
DOI:
10.3390/vaccines11030507
Language:
English
Publisher:
MDPI AG
Publication Date:
2023
detail.hit.zdb_id:
2703319-3
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