In:
Monaldi Archives for Chest Disease, PAGEPress Publications, ( 2021-09-28)
Abstract:
The COVID-19 pandemic caused a serious health challenge to the entire mankind. The association between clinical characteristics of disease and formation of neutralizing antibodies have not well studied. A prospective study was conducted for patients recovered from confirmed SARS-CoV-2 infections from 1st August 2020 to 28th February 2021, to study the association between SARS-CoV-2 IgG antibody response titres and clinical characteristics of the disease. A total 92 patients were included in the study. Median age was 52 years; majority were male and middle or old aged. About 48% patients required hospitalization and 38.3% had moderate CT severity score. Positive SARS-CoV-2-IgG was detected in all patients except one. On comparing the antibody titres among various sub-groups of COVID-19 recovered patients, old age was the only factor associated with statistically significant higher antibody response (28 AU/ml for age 〈 35 years, 53 AU/ml for age group 35-60, and 71 AU/ml for age group 〉 60 years, p value=0.01). Severity of infection, worse CT severity scores, need of hospitalization, oxygen or ventilatory support were associated with higher antibody titres but were not statistically significant. There was a strong correlation of antibody titres when analysed for age of study population (Spearman correlation=0.39, p value 〈 0.001); whereas a weak correlation (Spearman correlation=0.03, p value 0.753) was seen when analysed for CT severity score. Elderly patients had higher antibody titre after recovery from Covid-19 infection. Severity of disease, need of hospitalisation or oxygen/mechanical ventilation did not influence the antibody titre.
Type of Medium:
Online Resource
ISSN:
2532-5264
,
1122-0643
DOI:
10.4081/monaldi.2021.1943
Language:
Unknown
Publisher:
PAGEPress Publications
Publication Date:
2021
detail.hit.zdb_id:
2375904-5
detail.hit.zdb_id:
2375907-0
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