In:
eLife, eLife Sciences Publications, Ltd, Vol. 7 ( 2018-06-15)
Abstract:
The origin of Langerhans cells (LCs), which are skin epidermis-resident macrophages, remains unclear. Current lineage tracing of LCs largely relies on the promoter-Cre-LoxP system, which often gives rise to contradictory conclusions with different promoters. Thus, reinvestigation with an improved tracing method is necessary. Here, using a laser-mediated temporal-spatial resolved cell labeling method, we demonstrated that most adult LCs originated from the ventral wall of the dorsal aorta (VDA), an equivalent to the mouse aorta, gonads, and mesonephros (AGM), where both hematopoietic stem cells (HSCs) and non-HSC progenitors are generated. Further fine-fate mapping analysis revealed that the appearance of LCs in adult zebrafish was correlated with the development of HSCs, but not T cell progenitors. Finally, we showed that the appearance of tissue-resident macrophages in the brain, liver, heart, and gut of adult zebrafish was also correlated with HSCs. Thus, the results of our study challenged the EMP-origin theory for LCs.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.36131.001
DOI:
10.7554/eLife.36131.002
DOI:
10.7554/eLife.36131.005
DOI:
10.7554/eLife.36131.003
DOI:
10.7554/eLife.36131.004
DOI:
10.7554/eLife.36131.006
DOI:
10.7554/eLife.36131.009
DOI:
10.7554/eLife.36131.007
DOI:
10.7554/eLife.36131.008
DOI:
10.7554/eLife.36131.010
DOI:
10.7554/eLife.36131.011
DOI:
10.7554/eLife.36131.012
DOI:
10.7554/eLife.36131.013
DOI:
10.7554/eLife.36131.014
DOI:
10.7554/eLife.36131.017
DOI:
10.7554/eLife.36131.015
DOI:
10.7554/eLife.36131.016
DOI:
10.7554/eLife.36131.018
DOI:
10.7554/eLife.36131.019
DOI:
10.7554/eLife.36131.020
DOI:
10.7554/eLife.36131.022
DOI:
10.7554/eLife.36131.023
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2018
detail.hit.zdb_id:
2687154-3
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