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  • 1
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    Screening of osteoporosis and sarcopenia in individuals aged 50 years and older at different altitudes in Yunnan province: Protocol of a longitudinal cohort study
    Frontiers Media SA ; 2022
    In:  Frontiers in Endocrinology Vol. 13 ( 2022-11-14)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-11-14)
    Abstract: Musculoskeletal system gradually degenerates with aging, and a hypoxia environment at a high altitude may accelerate this process. However, the comprehensive effects of high-altitude environments on bones and muscles remain unclear. This study aims to compare the differences in bones and muscles at different altitudes, and to explore the mechanism and influencing factors of the high-altitude environment on the skeletal muscle system. Methods This is a prospective, multicenter, cohort study, which will recruit a total of 4000 participants over 50 years from 12 research centers with different altitudes (50m~3500m). The study will consist of a baseline assessment and a 5-year follow-up. Participants will undergo assessments of demographic information, anthropomorphic measures, self-reported questionnaires, handgrip muscle strength assessment (HGS), short physical performance battery (SPPB), blood sample analysis, and imaging assessments (QCT and/or DXA, US) within a time frame of 3 days after inclusion. A 5-year follow-up will be conducted to evaluate the changes in muscle size, density, and fat infiltration in different muscles; the muscle function impairment; the decrease in BMD; and the osteoporotic fracture incidence. Statistical analyses will be used to compare the research results between different altitudes. Multiple linear, logistic regression and classification tree analyses will be conducted to calculate the effects of various factors (e.g., altitude, age, and physical activity) on the skeletal muscle system in a high-altitude environment. Finally, a provisional cut-off point for the diagnosis of sarcopenia in adults at different altitudes will be calculated. Ethics and dissemination The study has been approved by the institutional research ethics committee of each study center (main center number: KHLL2021-KY056). Results will be disseminated through scientific conferences and peer-reviewed publications, as well as meetings with stakeholders. Clinical Trial registration number http://www.chictr.org.cn/index.aspx , identifier ChiCTR2100052153.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    DOI: 10.3389/fendo.2022.1010102
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2592084-4
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  • 2
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    Controlling the morphology and wavelength of self-assembled coaxial GaAs/Ga(As)Sb/GaAs single quantum-well nanowires
    Royal Society of Chemistry (RSC) ; 2023
    In:  Physical Chemistry Chemical Physics Vol. 25, No. 2 ( 2023), p. 1248-1256
    Details
    In: Physical Chemistry Chemical Physics, Royal Society of Chemistry (RSC), Vol. 25, No. 2 ( 2023), p. 1248-1256
    Abstract: Antimonide-based ternary III–V nanowires (NWs) provide a tunable bandgap over a wide range, and the GaAsSb material system has prospective applications in the 1.3–1.55 μm spectral range of optical communications. In this paper, GaAs/Ga(As)Sb/GaAs single quantum well (SQW) NWs were grown on Si(111) substrates by molecular beam epitaxy (MBE). In addition, the morphologies and tunable wavelengths of the GaAs/Ga(As)Sb/GaAs SQWs were adjusted by interrupting the Ga droplets and changing the growth temperatures and V/III ratios. The four morphologies of the GaAs/Ga(As)Sb/GaAs SQW NWs were observed by scanning electron microscopy (SEM). The microscale lattice structure related to the incorporation of Sb in GaAs/Ga(As)Sb/GaAs SQWs was studied by Raman spectroscopy. The crystal quality of the GaAs/Ga(As)Sb/GaAs SQW NWs was researched by X-ray diffraction (XRD) and transmission electron microscopy (TEM). In addition, the optical properties of the GaAs/Ga(As)Sb/GaAs SQWs were investigated by photoluminescence (PL) spectroscopy. The PL spectra showed the peak emission wavelength range of ∼818 nm (GaAs) to ∼1628 nm (GaSb) at 10 K. This study provides an approach to enhance the effective control of the morphology, structure and wavelength of quantum well or core–shell NWs.
    Type of Medium: Online Resource
    ISSN: 1463-9076 , 1463-9084
    URL: Article
    DOI: 10.1039/D2CP04630J
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 1476283-3
    detail.hit.zdb_id: 1476244-4
    detail.hit.zdb_id: 1460656-2
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  • 3
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    The influence of different Cu species onto multi-copper-contained hybrid materials’ photocatalytic property and mechanism of chlorophenol degradation
    Elsevier BV ; 2017
    In:  Applied Catalysis B: Environmental Vol. 214 ( 2017-10), p. 78-88
    Details
    In: Applied Catalysis B: Environmental, Elsevier BV, Vol. 214 ( 2017-10), p. 78-88
    Type of Medium: Online Resource
    ISSN: 0926-3373
    URL: Article
    DOI: 10.1016/j.apcatb.2017.05.033
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 2017331-3
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  • 4
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    Live-attenuated ME49Δcdpk3 strain of Toxoplasma gondii protects against acute and chronic toxoplasmosis
    Springer Science and Business Media LLC ; 2022
    In:  npj Vaccines Vol. 7, No. 1 ( 2022-08-20)
    Details
    In: npj Vaccines, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2022-08-20)
    Abstract: Toxoplasmosis, a common parasitic disease, is caused by Toxoplasma gondii , which infects approximately 30% of the world’s population. This obligate intracellular protozoan causes significant economic losses and poses serious public health challenges worldwide. However, the development of an effective toxoplasmosis vaccine in humans remains a challenge to date. In this study, we observed that the knockout of calcium-dependent protein kinase 3 (CDPK3) in the type II ME49 strain greatly attenuated virulence in mice and significantly reduced cyst formation. Hence, we evaluated the protective immunity of ME49Δ cdpk3 as a live attenuated vaccine against toxoplasmosis. Our results showed that ME49Δ cdpk3 vaccination triggered a strong immune response marked by significantly elevated proinflammatory cytokine levels, such as IFN-γ, IL-12, and TNF-α, and increased the percentage of CD4 +  and CD8 +  T-lymphocytes. The high level of Toxoplasma -specific IgG was maintained, with mixed IgG1/IgG2a levels. Mice vaccinated with ME49Δ cdpk3 were efficiently protected against the tachyzoites of a variety of wild-type strains, including type I RH, type II ME49, Chinese 1 WH3 and Chinese 1 WH6, as well as the cysts of wild-type strains ME49 and WH6. These data demonstrated that ME49Δ cdpk3 inoculation induced effective cellular and humoral immune responses against acute and chronic Toxoplasma infections with various strains and was a potential candidate to develop a vaccine against toxoplasmosis.
    Type of Medium: Online Resource
    ISSN: 2059-0105
    URL: Article
    DOI: 10.1038/s41541-022-00518-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2882262-6
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  • 5
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    Low latency microwave photonic RTFT processing based on bandwidth slicing and equivalent dispersion
    Optica Publishing Group ; 2023
    In:  Optics Letters Vol. 48, No. 12 ( 2023-06-15), p. 3131-
    Details
    In: Optics Letters, Optica Publishing Group, Vol. 48, No. 12 ( 2023-06-15), p. 3131-
    Abstract: Microwave photonic real-time Fourier transformation (RTFT) processing based on optical dispersion is a promising solution for microwave spectrum analysis. However, it usually brings the drawbacks of limited frequency resolution and large processing latency. Here, we demonstrate a low-latency microwave photonic RTFT processing based on bandwidth slicing and equivalent dispersion. The input RF signal is first divided into different channels with the help of bandwidth slicing technique, and then finely analyzed by the fiber-loop based frequency-to-time mapping. In the proof-of-concept experiment, a 0.44-m fiber-loop offers an equivalent dispersion as high as 6 × 10 5  ps/nm with a small transmission latency of 50 ns. As a result, we can realize a wide instantaneous bandwidth of 1.35 GHz, a high frequency resolution of approximately 20 MHz, and a high acquisition frame rate of approximately 450 MHz, together with a total latency of less than 200 ns.
    Type of Medium: Online Resource
    ISSN: 0146-9592 , 1539-4794
    URL: Article
    DOI: 10.1364/OL.492528
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2023
    detail.hit.zdb_id: 243290-0
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  • 6
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    Characterization of differential modal group delay in few-mode fiber using a digital re-sampling technique
    Optica Publishing Group ; 2023
    In:  Optics Letters Vol. 48, No. 2 ( 2023-01-15), p. 223-
    Details
    In: Optics Letters, Optica Publishing Group, Vol. 48, No. 2 ( 2023-01-15), p. 223-
    Abstract: We characterize the differential modal group delay (DMGD) arising in few-mode fibers (FMFs) based on the digital re-sampling technique, which is commonly used in current digital signal processing flow at the receiver-side. When the DMGD of a 291-m two-mode fiber is characterized over the C-band by using a 500-Mb/s non-return-to-zero (NRZ) signal and 1-GSa/s real-time oscilloscope, the experimental results are consistent with the DMGD obtained from the traditional time-of-flight (TOF) method. However, the wide-bandwidth instruments of the traditional TOF method can be replaced by cheap ones with a bandwidth of only a few hundred MHz, but the same temporal precision is achieved. Moreover, our proposed DMGD characterization method is not limited by the number of guided modes arising in the FMF, together with the capability to obtain both the DMGD value and its sign between two arbitrary guided modes.
    Type of Medium: Online Resource
    ISSN: 0146-9592 , 1539-4794
    URL: Article
    DOI: 10.1364/OL.478350
    Language: English
    Publisher: Optica Publishing Group
    Publication Date: 2023
    detail.hit.zdb_id: 243290-0
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  • 7
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    Insulin-like growth factor-I prevents hypoxia-inducible factor-1 alpha-dependent G1/S arrest by activating cyclin E/cyclin-dependent kinase2 via the phoshatidylinositol-3 kinase/AKT/forkhead box O1/Cdkn1b pathway in porcine granulosa cells†
    Oxford University Press (OUP) ; 2019
    In:  Biology of Reproduction ( 2019-08-22)
    Details
    In: Biology of Reproduction, Oxford University Press (OUP), ( 2019-08-22)
    Abstract: As the follicle develops, the thickening of the granulosa compartment leads to progressively deficient supply of oxygen in granulosa cells (GCs) due to the growing distances from the follicular vessels. These conditions are believed to cause hypoxia in GCs during folliculogenesis. Upon hypoxic conditions, several types of mammalian cells have been reported to undergo cell cycle arrest. However, it remains unclear whether hypoxia exerts any impact on cell cycle progression of GCs. On the other hand, although the GCs may live in a hypoxic environment, their mitotic capability appears to be unaffected in growing follicles. It thus raises the question whether there are certain intraovarian factors that might overcome the inhibitory effects of hypoxia. The present study provides the first evidence suggesting that cobalt chloride (CoCl2)-mimicked hypoxia prevented G1-to-S cell cycle progression in porcine GCs. In addition, we demonstrated that the inhibitory effects of CoCl2 on GCs cell cycle are mediated through hypoxia-inducible factor-1 alpha/FOXO1/Cdkn1b pathway. Moreover, we identified insulin-like growth factor-I (IGF-I) as an intrafollicular factor required for cell cycle recovery by binding to IGF-I receptor in GCs suffering CoCl2 stimulation. Further investigations confirmed a role of IGF-I in preserving G1/S progression of CoCl2-treated GCs via activating the cyclin E/cyclin-dependent kinase2 complex through the phoshatidylinositol-3 kinase/protein kinase B (AKT)/FOXO1/Cdkn1b axis. Although the present findings were based on a hypoxia mimicking model by using CoCl2, our study might shed new light on the regulatory mechanism of GCs cell cycle upon hypoxic stimulation.
    Type of Medium: Online Resource
    ISSN: 0006-3363 , 1529-7268
    URL: Article
    DOI: 10.1093/biolre/ioz162
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 1469812-2
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  • 8
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    NitroDIGE analysis reveals inhibition of protein S-nitrosylation by epigallocatechin gallates in lipopolysaccharide-stimulated microglial cells
    Springer Science and Business Media LLC ; 2014
    In:  Journal of Neuroinflammation Vol. 11, No. 1 ( 2014-12)
    Details
    In: Journal of Neuroinflammation, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2014-12)
    Abstract: Nitric oxide (NO) is a signaling molecule regulating numerous cellular functions in development and disease. In the brain, neuronal injury or neuroinflammation can lead to microglial activation, which induces NO production. NO can react with critical cysteine thiols of target proteins forming S -nitroso-proteins. This modification, known as S -nitrosylation, is an evolutionarily conserved redox-based post-translational modification (PTM) of specific proteins analogous to phosphorylation. In this study, we describe a protocol for analyzing S -nitrosylation of proteins using a gel-based proteomic approach and use it to investigate the modes of action of a botanical compound found in green tea, epigallocatechin-3-gallate (EGCG), on protein S -nitrosylation after microglial activation. Methods/Results To globally and quantitatively analyze NO-induced protein S -nitrosylation, the sensitive gel-based proteomic method, termed NitroDIGE, was developed by combining two-dimensional differential in-gel electrophoresis (2-D DIGE) with the modified biotin switch technique (BST) using fluorescence-tagged CyDye™ thiol reactive agents to label S -nitrosothiols. The NitroDIGE method showed high specificity and sensitivity in detecting S -nitrosylated proteins (SNO-proteins). Using this approach, we identified a subset of SNO-proteins ex vivo by exposing immortalized murine BV-2 microglial cells to a physiological NO donor, or in vivo by exposing BV-2 cells to endotoxin lipopolysaccharides (LPS) to induce a proinflammatory response. Moreover, EGCG was shown to attenuate S -nitrosylation of proteins after LPS-induced activation of microglial cells primarily by modulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated oxidative stress response. Conclusions These results demonstrate that NitroDIGE is an effective proteomic strategy for “top-down” quantitative analysis of protein S -nitrosylation in multi-group samples in response to nitrosative stress due to excessive generation of NO in cells. Using this approach, we have revealed the ability of EGCG to down-regulate protein S -nitrosylation in LPS-stimulated BV-2 microglial cells, consistent with its known antioxidant effects.
    Type of Medium: Online Resource
    ISSN: 1742-2094
    URL: Article
    DOI: 10.1186/1742-2094-11-17
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2014
    detail.hit.zdb_id: 2156455-3
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  • 9
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    A NEW FRACTAL APPARENT PERMEABILITY MODEL FOR LIQUID FLOW IN TORTUOUS NANOPORES FROM LATTICE BOLTZMANN SIMULATIONS TO THE THEORETICAL MODEL
    World Scientific Pub Co Pte Ltd ; 2021
    In:  Fractals Vol. 29, No. 07 ( 2021-11)
    Details
    In: Fractals, World Scientific Pub Co Pte Ltd, Vol. 29, No. 07 ( 2021-11)
    Abstract: Tortuous pores are ubiquitous in natural porous media; however, the linear effects of tortuosity on the liquid flow behaviors are usually considered through capillary bundle models, which lead to inaccurate permeability prediction. Additionally, in the nanopores, due to the existence of heterogeneous viscosity and boundary slip, the effects of tortuosity on nanoconfined liquid flow behaviors are more complicated. In this paper, we comprehensively use the theoretical models and a nanoscale multi-relaxation-time lattice Boltzmann method (MRT-LBM) to characterize water flow behaviors in the tortuous nanopores, where heterogeneous viscosity and boundary slip are considered. The results show that the increase of tortuosity causes more negative effects, which results in a decreasing apparent permeability. The conventional model of the influence of tortuosity on the apparent permeability is linear[Formula: see text], which greatly underestimates the effect of tortuosity on apparent permeability. Then, a new fractal apparent permeability model [Formula: see text] based on modified tortuous effects is obtained by fitting the results from the MRT-LBM simulations. Based on the new fractal apparent permeability models, the results show that with an increasing fractal tortuosity dimension, the apparent permeability decreases rapidly first and then this trend becomes moderate. Our works can provide a more accurate basic model for studying liquid flow in porous media based on the capillary bundle model or pore network model.
    Type of Medium: Online Resource
    ISSN: 0218-348X , 1793-6543
    URL: Article
    DOI: 10.1142/S0218348X21502339
    Language: English
    Publisher: World Scientific Pub Co Pte Ltd
    Publication Date: 2021
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  • 10
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    Hydrogel–metal-organic-framework hybrids mediated efficient oral delivery of siRNA for the treatment of ulcerative colitis
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Nanobiotechnology Vol. 20, No. 1 ( 2022-09-05)
    Details
    In: Journal of Nanobiotechnology, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2022-09-05)
    Abstract: Ulcerative colitis (UC) is a major type of inflammatory bowel disease (IBD), which could induce bloody stool, diarrhea, colon atrophy and eventually lead to colorectal cancer. The conventional daily oral administration of drugs only relieve the inflammatory response of colon in the short term, Biological agents such as antibody drugs has proven its efficiency in inhibiting colitis, while the low drug bioavailability means that large doses of antibodies are required, ultimately causing systemic toxicity. Small interfering RNA (siRNA) has significant advantages over antibody drugs in terms of safety and efficacy, and it have been widely applied as potential candidates for a variety of inflammation-related diseases. However, oral delivery of siRNA fails to overcome the degradation of the gastrointestinal environment to produce a significant therapeutic effect in ulcerative colitis. Herein, we design the hybrid delivery system that the siRNA loaded MOF encapsulated in the sodium alginate particles to overcome the barriers in the oral process. Results The hybrid delivery system (SA@MOF-siRNA TNFα ) was successfully constructed, and it could not only survive the low pH environment in the stomach and small intestine, but also taken up more by inflammatory macrophages, as well as released much more MOF-siRNA TNFα . Moreover, SA@MOF-siRNA TNFα tended to enriched and infiltrated into local colon tissues. As a result, SA@MOF-siRNA TNFα significantly reduced the progression of colitis, of which the treated mice did not experience significant weight loss, bloody stools and diarrhea. Conclusion We confirmed that the formulation of hydrogel–metal-organic framework hybrids could improve the protection of incorporated payload in the gastric and early small intestine, enhancing the delivery of MOF-siRNA to colon.
    Type of Medium: Online Resource
    ISSN: 1477-3155
    URL: Article
    DOI: 10.1186/s12951-022-01603-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2100022-0
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