In:
Chemistry – A European Journal, Wiley, Vol. 26, No. 6 ( 2020-01-27), p. 1166-1195
Abstract:
Bryostatins are a class of naturally occurring macrocyclic lactones with a unique fast developing portfolio of clinical applications, including treatment of AIDS, Alzheimer's disease, and cancer. This comprehensive account summarizes the recent progress (2014–present) in the development of bryostatins, including their total synthesis and biomedical applications. An emphasis is placed on the discussion of bryostatin 1 , the most‐studied analogue to date. This review highlights the synthetic and biological challenges of bryostatins and provides an outlook on their future development.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201903128
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1478547-X
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