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  • 1
    In: Nuclear Science and Techniques, Springer Science and Business Media LLC, Vol. 34, No. 8 ( 2023-08)
    Type of Medium: Online Resource
    ISSN: 1001-8042 , 2210-3147
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2238719-5
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  • 2
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 133, No. 12 ( 2020-04-01), p. 1390-1396
    Abstract: Critical patients with the coronavirus disease 2019 (COVID-19), even those whose nucleic acid test results had turned negative and those receiving maximal medical support, have been noted to progress to irreversible fatal respiratory failure. Lung transplantation (LT) as the sole therapy for end-stage pulmonary fibrosis related to acute respiratory distress syndrome has been considered as the ultimate rescue therapy for these patients. Methods From February 10 to March 10, 2020, three male patients were urgently assessed and listed for transplantation. After conducting a full ethical review and after obtaining assent from the family of the patients, we performed three LT procedures for COVID-19 patients with illness durations of more than one month and extremely high sequential organ failure assessment scores. Results Two of the three recipients survived post-LT and started participating in a rehabilitation program. Pearls of the LT team collaboration and perioperative logistics were summarized and continually improved. The pathological results of the explanted lungs were concordant with the critical clinical manifestation, and provided insight towards better understanding of the disease. Government health affair systems, virology detection tools, and modern communication technology all play key roles towards the survival of the patients and their rehabilitation. Conclusions LT can be performed in end-stage patients with respiratory failure due to COVID-19-related pulmonary fibrosis. If confirmed positive-turned-negative virology status without organ dysfunction that could contraindicate LT, LT provided the final option for these patients to avoid certain death, with proper protection of transplant surgeons and medical staffs. By ensuring instant seamless care for both patients and medical teams, the goal of reducing the mortality rate and salvaging the lives of patients with COVID-19 can be attained.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2020
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 3
    Online Resource
    Online Resource
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2021
    In:  Acta Physica Sinica Vol. 70, No. 8 ( 2021), p. 082901-
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 70, No. 8 ( 2021), p. 082901-
    Abstract: At present, there exist few proton-beam terminals for the detector calibration in the world. Meanwhile, most of these terminals provide monoenergetic protons. Back-n white neutron source from China Spallation Neutron Source(CSNS) was put into operation in 2018. Based on the white neutron flux ranging from 0.5 eV to 200 MeV from the CSNS Back-n white neutron source, continuous-energy protons involved in a wide energy spectrum can be acquired from the 〈sup〉1〈/sup〉H(n, el) reaction. Adopting this method, a new research platform for researches such as proton calibration is realized at CSNS. As hydrogen exists as gas at normal temperature and pressure, in the selecting of the proton-converting target, the hydrogen-rich compounds are preferential considered. Considering the reaction cross sections of the 〈sup〉1〈/sup〉H(n, el), 〈sup〉12〈/sup〉C(n, p)〈sup〉12〈/sup〉B, 〈sup〉12〈/sup〉C(n, d)〈sup〉11〈/sup〉B, 〈sup〉12〈/sup〉C(n, t)〈sup〉10〈/sup〉B, 〈sup〉12〈/sup〉C(n, 〈sup〉3〈/sup〉He)〈sup〉10〈/sup〉Be, 〈sup〉12〈/sup〉C(n, α)〈sup〉9〈/sup〉Be and 〈sup〉1〈/sup〉H(n, γ)〈sup〉2〈/sup〉H, polyethylene and polypropylene are suitable for serving as targets in this research. Based on a 3U PXIe, digitizers with 1 GSps sampling rate and 12 bit resolution are utilized to digitize and record the output signals of telescopes. The time and amplitude information of each signal are extracted from its recorded waveform. Proton fluxes can be calculated by using the neutron energy spectrum and the cross section of the 〈sup〉1〈/sup〉H(n, el) reaction. Using the γ-flash event as the starting time of the time-of-flight (TOF) and the time information of signal in detector as the stopping time, the kinematic energy of each secondary proton can be deduced from the TOF and the angle of the detector. A calibration experiment on three charged particle telescopes, with each telescope consisting of a silicon detector and a CsI(Tl) detector, is carried out on this research platform. The readout methods of the CsI(Tl) detectors in these three telescopes are different. In the calibration experiment, Δ〈i〉E-〈/i〉〈i〉E〈/i〉 two-dimensional spectra and amplitude-〈i〉E〈/i〉〈sub〉p〈/sub〉 two-dimensional spectra of these telescopes are obtained. Through comparing these particle identification spectra, the SiPM is chosen as the signal readout method for CsI(Tl) detectors in the charged particle telescopes. These researches provide experimental evidence for the construction of the charged particle telescope at Back-n, and also illustrate the feasibility of wide-energy spectrum proton calibration based on the Back-n white neutron source.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2021
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  • 4
    Online Resource
    Online Resource
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2021
    In:  Acta Physica Sinica Vol. 70, No. 22 ( 2021), p. 222801-
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 70, No. 22 ( 2021), p. 222801-
    Abstract: The data of neutron capture cross section are very important for the research of nuclear astrophysics, advanced nuclear energy development. Owing to the limitation of neutron source and detector, the experimental data of neutron capture cross section in an energy range of 1 eV–10 keV were almost blank in China. The first Chinese gamma-ray total absorption facility has been constructed in the key laboratory of nuclear data at China institute of atomic energy, which consists of 40 BaF〈sub〉2〈/sub〉 detector units. The BaF〈sub〉2〈/sub〉 crystal shell with a thickness of 15 cm and an inner radius of 10 cm covers 95.2% of the solid angle. On-line measurement method of neutron capture reaction cross section is established on the back-streaming white neutron source of China spallation neutron source by using the upgraded facility. The cross section of 〈sup〉197〈/sup〉Au neutron capture reaction is measured for the first time under the experimental condition of irregular 30 mm neutron beam spot. The measured position of resonance peak is well consistent with the relevant data of ENDF evaluation database, which verifies the reliability of the measurement device and measurement technology, and thus laying the foundation for the acquisition of high precision cross section in future.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2021
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  • 5
    In: Nuclear Science and Techniques, Springer Science and Business Media LLC, Vol. 32, No. 1 ( 2021-01)
    Type of Medium: Online Resource
    ISSN: 1001-8042 , 2210-3147
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2238719-5
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  • 6
    Online Resource
    Online Resource
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2024
    In:  Acta Physica Sinica Vol. 73, No. 7 ( 2024), p. 072801-
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 73, No. 7 ( 2024), p. 072801-
    Abstract: Neutron capture reaction is one of the neutron reactions and plays an important role in using reactor control rods and shell materials, designing nuclear device structures, and studying nuclear astrophysics S processes and element origins. The 4π BaF 〈 sub 〉 2 〈 /sub 〉 detection device has advantages such as high time resolution, low neutron sensitivity, and high detection efficiency, thus making it suitable for measuring neutron radiation capture reaction cross-section data. In order to fill the gap in our neutron capture reaction data in the keV energy range and improve their accuracy, the Key Laboratory of Nuclear Data at the Chinese Institute of Atomic Energy (CIAE) has established a Gamma Total Absorption Facility (GTAF), which consists of 28 hexagonal BaF 〈 sub 〉 2 〈 /sub 〉 crystals and 12 pentagonal BaF 〈 sub 〉 2 〈 /sub 〉 crystals to form a spherical shell with an external diameter of 25 cm and an internal diameter of 10 cm, covering 95.2% of the solid angles. The Back-n beam line of the Chinese Spallation Neutron Source (CSNS) is a back-streaming white beam line that covers neutron energy ranging from a few eV to several hundred MeV, making it suitable for measuring neutron capture cross-sections. The reaction cross-section data of 〈 sup 〉 197 〈 /sup 〉 Au is measured by using GTAF on the Back-n beam line. The measurement data are preliminarily background deducted through energy screening, PSD method, and crystal multiplicity screening. Subsequently, the background is analyzed and deducted based on the measurement data of 〈 sup 〉 nat 〈 /sup 〉 C and empty samples, and the yield of 〈 sup 〉 197 〈 /sup 〉 Au capture reaction is obtained. Resonance parameters are a set of parameters extracted from experimental data to describe the resonance curve, which can eliminate the influence of experimental conditions on resonance data and are more important than the cross-section obtained from experiments. The resonance energy, neutron resonance width, and gamma resonance width parameters of 〈 sup 〉 197 〈 /sup 〉 Au at 1–100 eV are fitted by using the SAMMY program. From the comparison between the resonance curves obtained from experimental measurements and the resonance parameters obtained from fitting with the ENDF/B-VIII.0 database, it can follow that the experimental measurement results are in good agreement with the database, nevertheless, there exist some differences in the resonance parameter, which may be due to the GTAF energy resolution, Back-n neutron spectrum measurement accuracy, and the experimental background deduction method. Our next work is to identify the sources of difference.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2024
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  • 7
    Online Resource
    Online Resource
    Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences ; 2020
    In:  Acta Physica Sinica Vol. 69, No. 17 ( 2020), p. 172901-
    In: Acta Physica Sinica, Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences, Vol. 69, No. 17 ( 2020), p. 172901-
    Abstract: The back-streaming neutron beam line (Back-n) was built in the beginning of 2018, which is part of the China Spallation Neutron Source (CSNS). The Back-n is the first white neutron beam line in China, and its main application is for nuclear data measurement. For most of neutron-induced nuclear reaction measurements based on white neutron facilities, the beam of gamma rays accompanied with neutron beam is one of the most important experimental backgrounds. The back streaming neutron beam is transported directly from the spallation target to the experimental station without any moderator or shielding, the flux of the in-beam gamma rays in the experimental station is much larger than those of these facilities with neutron moderator and shielding. Therefore, it is necessary to consider the influence of in-beam gamma rays on the experimental results. Studies of the in-beam gamma rays are carried out at the back-n. Monte-Carlo simulation is employed to obtain the energy distribution and the time structure of the in-beam gamma rays. According to the simulation results, when the neutron flight time is longer than 1.0 μs the energy distribution of the in-beam gamma rays does not vary with flight time. Therefore, the time structure of these gamma rays can be measured without the correction of the detection efficiency. In this work, the time structure of the in-beam gamma rays in the low neutron energy region is measured by both direct and indirect methods. In the direct measurement, a 〈sup〉6〈/sup〉Li loaded ZnS(Ag) scintillator is located on the neutron beam line and the time of flight method is used to determine the time structure of neutrons and gamma rays. The gamma rays are separated from neutrons with pulse-shape discrimination. The black filter method is used to verify the particle discrimination results. In the indirect measurement, the C〈sub〉6〈/sub〉D〈sub〉6〈/sub〉 scintillation detectors are used to measure the gamma rays scattered off a Pb sample on the way of the neutron beam. The time structure of the in-beam gamma rays is derived from that of the scattered gamma rays. The experimental results are in good agreement with the simulations with the time-of-flight between 12 μs and 2.0 ms. Besides, according to the simulation results, the intensity of the in-beam gamma rays is 1.21 × 10〈sup〉6〈/sup〉 s〈sup〉–1〈/sup〉·cm〈sup〉–2〈/sup〉 in the center of the experimental station 2 of Back-n, which is 76.5 m away from the spallation target of CSNS.
    Type of Medium: Online Resource
    ISSN: 1000-3290 , 1000-3290
    Language: Unknown
    Publisher: Acta Physica Sinica, Chinese Physical Society and Institute of Physics, Chinese Academy of Sciences
    Publication Date: 2020
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  • 8
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2010
    In:  Journal of Shanghai University (English Edition) Vol. 14, No. 4 ( 2010-8), p. 241-245
    In: Journal of Shanghai University (English Edition), Springer Science and Business Media LLC, Vol. 14, No. 4 ( 2010-8), p. 241-245
    Type of Medium: Online Resource
    ISSN: 1007-6417 , 1863-236X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2010
    detail.hit.zdb_id: 2379454-9
    SSG: 11
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  • 9
    In: European Journal of Neurology, Wiley, Vol. 29, No. 11 ( 2022-11), p. 3218-3228
    Abstract: Recent genetic progress has shown many causative/risk genes linked to Parkinson's disease (PD), mainly in patients of European ancestry. The study aimed to investigate the PD‐related genes and determine the mutational spectrum of early‐onset PD in ethnic Chinese. Methods In this study, whole‐exome sequencing and/or gene dosage analysis were performed in 704 early‐onset PD (EOPD) patients (onset age ≤45 years) and 1866 controls. Twenty‐six PD‐related genes and 20 other genes linked to neurodegenerative and lysosome diseases were analysed. Results Eighty‐two (11.6%, 82/704) EOPD patients carrying rare pathogenic/likely pathogenic variants in PD‐related genes were identified. The mutation frequency in autosomal recessive inheritance EOPD (42.9%, 27/63) was much higher than that in autosomal dominant inheritance EOPD (0.9%, 12/110) or sporadic EOPD (8.1%, 43/531). Bi‐allelic mutations in PRKN were the most frequent, accounting for 5.1% of EOPD cases. Three common pathogenic variants, p.A53V in SNCA , p.G284R in PRKN and p.P53Afs*38 in CHCHD2 , occur exclusively in Asians. The putative damaging variants from GBA , PRKN , DJ1 , PLA2G6 and GCH1 contributed to the collective risk for EOPD. Notably, the protein‐truncating variants in CHCHD2 were enriched in EOPD, especially for p.P53Afs*38, which was also found in three patients from an independent cohort of patients with late‐onset PD ( n  = 1300). Functional experiments confirmed that truncated CHCHD2 variants cause loss of function and are linked to mitochondrial dysfunction. Conclusions Our study reveals that the genetic spectrum of EOPD in Chinese, which may help develop genetic scanning strategies, provided more evidence supporting CHCHD2 in PD.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020241-6
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  • 10
    In: Journal of Integrative Medicine, Elsevier BV, Vol. 12, No. 3 ( 2014-05), p. 175-181
    Type of Medium: Online Resource
    ISSN: 2095-4964
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 2705619-3
    detail.hit.zdb_id: 2587454-8
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