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  • 1
    Online Resource
    Online Resource
    Development of a portable NIR rice wine analyzer
    Shanghai Institute of Optics and Fine Mechanics ; 2011
    In:  Chinese Optics Letters Vol. 9, No. s1 ( 2011), p. s10706-310708
    Details
    In: Chinese Optics Letters, Shanghai Institute of Optics and Fine Mechanics, Vol. 9, No. s1 ( 2011), p. s10706-310708
    Type of Medium: Online Resource
    ISSN: 1671-7694
    Uniform Title: Development of a portable NIR rice wine analyzer
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.3788/COL/2011/9/s1
    DOI: 10.3788/COL
    DOI: 10.3788/COL201109.s10706
    Language: English , Chinese
    Publisher: Shanghai Institute of Optics and Fine Mechanics
    Publication Date: 2011
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  • 2
    Online Resource
    Online Resource
    915 nm Light‐Triggered Photodynamic Therapy and MR/CT Dual‐Modal Imaging of Tumor Based on the Nonstoichiometric Na 0.52 YbF 3.52 :Er Upconversion Nanoprobes
    Wiley ; 2016
    In:  Small Vol. 12, No. 31 ( 2016-08), p. 4200-4210
    Details
    In: Small, Wiley, Vol. 12, No. 31 ( 2016-08), p. 4200-4210
    Abstract: Lanthanide (Ln 3+ )‐doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na 0.52 YbF 3.52 :Er UCNPs of high luminescence intensity and color purity are synthesized via a facile solvothermal method. The red UC emission from the present nanophosphors is three times more intense than the well‐known green emission from the ≈30 nm sized hexagonal‐phase NaYF 4 :Yb,Er UCNPs. By utilizing Na 0.52 YbF 3.52 :Er@SrF 2 UCNPs as multifunctional nanoplatforms, highly efficient in vitro and in vivo 915 nm light‐triggered photodynamic therapies are realized for the first time, with dramatically diminished overheating yet similar therapeutic effects in comparison to those triggered by 980 nm light. Moreover, by virtue of the high transverse relaxivity ( r 2 ) and the strong X‐ray attenuation ability of Yb 3+ ions, these UCNPs also demonstrate good performances as contrast agents for high contrast magnetic resonance and X‐ray computed tomography dual‐modal imaging. Our research shows the great potential of the red emitting Na 0.52 YbF 3.52 :Er UCNPs for multimodal imaging‐guided photodynamic therapy of tumors.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v12.31
    DOI: 10.1002/smll.201601023
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2168935-0
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  • 3
    Online Resource
    Online Resource
    Table1.xlsx
    Frontiers Media SA ; 2023
    In:  Frontiers in Surgery Vol. 9 ( 2023-1-6)
    Details
    In: Frontiers in Surgery, Frontiers Media SA, Vol. 9 ( 2023-1-6)
    Abstract: Tuberculosis (TB) is a chronic infectious disease. Bone and joint TB is a common type of extrapulmonary TB and often occurs secondary to TB infection. In this study, we aimed to find the difference in the blood examination results of patients with bone and joint TB and patients with TB by using machine learning (ML) and establish a diagnostic model to help clinicians better diagnose the disease and allow patients to receive timely treatment. Methods A total of 1,667 patients were finally enrolled in the study. Patients were randomly assigned to the training and validation cohorts. The training cohort included 1,268 patients: 158 patients with bone and joint TB and 1,110 patients with TB. The validation cohort included 399 patients: 48 patients with bone and joint TB and 351 patients with TB. We used three ML methods, namely logistic regression, LASSO regression, and random forest, to screen the differential variables, obtained the most representative variables by intersection to construct the prediction model, and verified the performance of the proposed prediction model in the validation group. Results The results revealed a great difference in the blood examination results of patients with bone and joint TB and those with TB. Infectious markers such as hs-CRP, ESR, WBC, and NEUT were increased in patients with bone and joint TB. Patients with bone and joint TB were found to have higher liver function burden and poorer nutritional status. The factors screened using ML were PDW, LYM, AST/ALT, BUN, and Na, and the nomogram diagnostic model was constructed using these five factors. In the training cohort, the area under the curve (AUC) value of the model was 0.71182, and the C value was 0.712. In the validation cohort, the AUC value of the model was 0.6435779, and the C value was 0.644. Conclusion We used ML methods to screen out the blood-specific factors—PDW, LYM, AST/ALT, BUN, and Na + —of bone and joint TB and constructed a diagnostic model to help clinicians better diagnose the disease in the future.
    Type of Medium: Online Resource
    ISSN: 2296-875X
    URL: Article
    URL: Article
    DOI: 10.3389/fsurg.2022.1031105
    DOI: 10.3389/fsurg.2022.1031105.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2773823-1
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  • 4
    Online Resource
    Online Resource
    Mechanism of Hip Arthropathy in Ankylosing Spondylitis: Abnormal Myeloperoxidase and Phagosome
    Frontiers Media SA ; 2021
    In:  Frontiers in Immunology Vol. 12 ( 2021-11-22)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2021-11-22)
    Abstract: The pathogenesis of Ankylosing spondylitis (AS) has not been elucidated, especially involving hip joint disease. The purpose of this study was to analyze the proteome of diseased hip in AS and to identify key protein biomarkers. Material and Methods We used label-free quantification combined with liquid chromatography mass spectrometry (LC–MS/MS) to screen for differentially expressed proteins in hip ligament samples between AS and No-AS groups. Key protein was screened by Bioinformatics methods. and verified by in vitro experiments. Results There were 3,755 identified proteins, of which 92.916% were quantified. A total of 193 DEPs (49 upregulated proteins and 144 downregulated proteins) were identified according to P & lt; 0.01 and Log|FC| & gt; 1. DEPs were mainly involved in cell compartment, including the vacuolar lumen, azurophil granule, primary lysosome, etc. The main KEGG pathway included Phagosome, Glycerophospholipid metabolism, Lysine degradation, Pentose phosphate pathway. Myeloperoxidase (MPO) was identified as a key protein involved in Phagosome pathway. The experiment of siRNA interfering with cells further confirmed that the upregulated MPO may promote the inflammatory response of fibroblasts. Conclusions The overexpression of MPO may contribute to the autoimmune inflammatory response of AS-affected hip joint through the phagosome pathway.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    DOI: 10.3389/fimmu.2021.572592
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606827-8
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  • 5
    Online Resource
    Online Resource
    DataSheet_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 12 ( 2022-1-18)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 12 ( 2022-1-18)
    Abstract: The mechanism of ankylosing spondylitis with femoral head necrosis is unknown, and our study aimed investigate the effects of genetic and immune cell dysregulation on ankylosing spondylitis. Materials and Methods The protein expression of all ligaments in ankylosing spondylitis with femoral head necrosis was obtained using label-free quantification protein park analysis of six pairs of specimens. The possible pathogenesis was explored using differential protein analysis, weighted gene co-expression network analysis, recording intersections with hypoxia-related genes, immune cell correlation analysis, and drug sensitivity analysis. Finally, routine blood test data from 502 AS and 162 healthy controls were collected to examine immune cell differential analysis. Results SAA1 and TUBA8 were significantly expressed differentially in these two groups and correlated quite strongly with macrophage M0 and resting mast cells (P & lt; 0.05). Routine blood data showed that monocytes were significantly more expressed in AS than in healthy controls (P & lt; 0.05). SAA1 and TUBA8 were closely related to the sensitivity of various drugs, which might lead to altered drug sensitivity. Conclusion Dysregulation of SAA1, TUBA8 and monocytes are key factors in ankylosing spondylitis with femoral head necrosis.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2021.814278
    DOI: 10.3389/fimmu.2021.814278.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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  • 6
    Online Resource
    Online Resource
    Upregulated of ANXA3, SORL1, and Neutrophils May Be Key Factors in the Progressionof Ankylosing Spondylitis
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-4-6)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-4-6)
    Abstract: The specific pathogenesis of ankylosing spondylitis (AS) remains unclear, and our study aimed to investigate the possible pathogenesis of AS. Materials and Methods Two datasets were downloaded from the GEO database to perform differentially expressed gene analysis, GO enrichment analysis, KEGG pathway analysis, DO enrichment analysis, GSEA analysis of differentially expressed genes, and construction of diagnostic genes using SVM and WGCNA along with Hypoxia-related genes. Also, drug sensitivity analysis was performed on diagnostic genes. To identify the differentially expressed immune genes in the AS and control groups, we analyzed the composition of immune cells between them. Then, we examined differentially expressed genes in three AS interspinous ligament specimens and three Degenerative lumbar spine specimens using high-throughput sequencing while the immune cells were examined using the neutrophil count data from routine blood tests of 1770 HLA-B27-positive samples and 7939 HLA-B27-negative samples. To assess the relationship between ANXA3 and SORL1 and disease activity, we took the neutrophil counts of the first 50 patients with above-average BASDAI scores and the last 50 patients with below-average BASDAI scores for statistical analysis. We used immunohistochemistry to verify the expression of ANXA3 and SORL1 in AS and in controls. Results ANXA3 and SORL1 were identified as new diagnostic genes for AS. These two genes showed a significant differential expression between AS and controls, along with showing a significant positive correlation with the neutrophil count. The results of high-throughput sequencing verified that these two gene deletions were indeed differentially expressed in AS versus controls. Data from a total of 9707 routine blood tests showed that the neutrophil count was significantly higher in AS patients than in controls (p & lt; 0.001). Patients with AS with a high BASDAI score had a much higher neutrophil count than those with a low score, and the difference was statistically significant (p & lt; 0.001). The results of immunohistochemistry showed that the expression of ANXA3 and SORL1 in AS was significantly higher than that in the control group. Conclusion Upregulated of ANXA3, SORL1, and neutrophils may be a key factor in the progression of Ankylosing spondylitis.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    DOI: 10.3389/fimmu.2022.861459
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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  • 7
    Online Resource
    Online Resource
    Facile synthesis of Ni 3 Se 4 /Ni 0.6 Zn 0.4 O/ZnO nanoparticle as high-performance electrode materials for electrochemical energy storage device
    IOP Publishing ; 2023
    In:  Nanotechnology Vol. 34, No. 18 ( 2023-04-30), p. 185401-
    Details
    In: Nanotechnology, IOP Publishing, Vol. 34, No. 18 ( 2023-04-30), p. 185401-
    Abstract: To enhance the performance of transition metal chalcogenide composite electrode material, a key point is a composite design and preparation based on the synergistic effect between the oxide and selenide materials. With a facile ‘one step template-annealing’ step, Ni 3 Se 4 , Ni 0.6 Zn 0.4 O and ZnO are simultaneously synthesized, by 500 °C annealing. With the increase of annealing temperature from 350 °C to 600 °C, nickel selenides change from NiSe 2 to Ni 3 Se 4 to NiSe. The charge storage capacity increases first and then decreases with the increase of annealing temperature, and the 500 °C annealing obtained three compound composite Ni 3 Se 4 /Ni 0.6 Zn 0.4 O/ZnO (NNZ-500) nanoparticle material displayed a high specific capacitance of 1089.2 F g −1 at 1 A g −1 , and excellent cycle stability of 99.8% capacitance retention after 2000 cycles at 5 A g −1 . Moreover, an asymmetric supercapacitor was assembled with NNZ-500 as the positive electrode material and activated carbon as the negative electrode material. This kind of asymmetric supercapacitor demonstrated a high energy density of 53.4 Wh kg −1 at 819.0 W kg −1 , and cycle stability with 98.6% capacitance retention after 2000 cycles. This material preparation approach provides great potential for the future development of high performance transition metal composite electrode materials in energy storage applications.
    Type of Medium: Online Resource
    ISSN: 0957-4484 , 1361-6528
    URL: Article
    DOI: 10.1088/1361-6528/acb4f1
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 1362365-5
    SSG: 11
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  • 8
    Online Resource
    Online Resource
    Application of machine learning in prediction of bone cement leakage during single-level thoracolumbar percutaneous vertebroplasty
    Springer Science and Business Media LLC ; 2023
    In:  BMC Surgery Vol. 23, No. 1 ( 2023-03-23)
    Details
    In: BMC Surgery, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-03-23)
    Abstract: In the elderly, osteoporotic vertebral compression fractures (OVCFs) of the thoracolumbar vertebra are common, and percutaneous vertebroplasty (PVP) is a common surgical method after fracture. Machine learning (ML) was used in this study to assist clinicians in preventing bone cement leakage during PVP surgery. Methods The clinical data of 374 patients with thoracolumbar OVCFs who underwent single-level PVP at The First People's Hospital of Chenzhou were chosen. It included 150 patients with bone cement leakage and 224 patients without it. We screened the feature variables using four ML methods and used the intersection to generate the prediction model. In addition, predictive models were used in the validation cohort. Results The ML method was used to select five factors to create a Nomogram diagnostic model. The nomogram model's AUC was 0.646667, and its C value was 0.647. The calibration curves revealed a consistent relationship between nomogram predictions and actual probabilities. In 91 randomized samples, the AUC of this nomogram model was 0.7555116. Conclusion In this study, we invented a prediction model for bone cement leakage in single-segment PVP surgery, which can help doctors in performing better surgery with reduced risk.
    Type of Medium: Online Resource
    ISSN: 1471-2482
    URL: Article
    DOI: 10.1186/s12893-023-01959-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2050442-1
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  • 9
    Online Resource
    Online Resource
    Two-Step Synthesis of ZnS-NiS2 Composite with Rough Nanosphere Morphology for High-Performance Asymmetric Supercapacitors
    MDPI AG ; 2023
    In:  Batteries Vol. 10, No. 1 ( 2023-12-31), p. 16-
    Details
    In: Batteries, MDPI AG, Vol. 10, No. 1 ( 2023-12-31), p. 16-
    Abstract: Transition metal sulfides have excellent electrochemical performance and show great potential for improving the energy density of asymmetric supercapacitors. This study demonstrates a two-step synthesis technique and highlights the enhanced energy storage efficiency of ZnS-NiS2 composite materials for asymmetric supercapacitors. The composite materials of ZnS nanosheets and NiS2 nanocrystals are characterized by a rough surface and spherical shape. The sample with the optimal ratio (ZnS-NiS2-1:7) exhibits a maximum specific capacitance of 1467.9 F g−1 (550.5 C g−1) at 1 A g−1. The specific capacitance of the ZnS-NiS2-1:7 sample is 26.1% higher compared to the pure NiS2 sample. Furthermore, the assembled ZnS-NiS2-1:7//AC device shows a high specific capacitance of 127.8 F g−1 (217.3 C g−1) at 1 A g−1 and an energy density of 51.3 Wh kg−1 at a power density of 820.8 W kg−1. The ZnS-NiS2-1:7 sample has exceptional energy storage capability on its own, but it can also be composited with graphene to further increase the specific capacitance (1681.0 F g−1 at 1 A g−1), suggesting promising prospects for the ZnS-NiS2-based composite material in the future.
    Type of Medium: Online Resource
    ISSN: 2313-0105
    URL: Article
    DOI: 10.3390/batteries10010016
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2813972-0
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  • 10
    Online Resource
    Online Resource
    Methane dry reforming over boron nitride interface-confined and LDHs-derived Ni catalysts
    Elsevier BV ; 2019
    In:  Applied Catalysis B: Environmental Vol. 252 ( 2019-09), p. 86-97
    Details
    In: Applied Catalysis B: Environmental, Elsevier BV, Vol. 252 ( 2019-09), p. 86-97
    Type of Medium: Online Resource
    ISSN: 0926-3373
    URL: Article
    DOI: 10.1016/j.apcatb.2019.04.007
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2017331-3
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