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  • 1
    In: Acta Diabetologica, Springer Science and Business Media LLC, Vol. 47, No. 3 ( 2010-9), p. 231-236
    Type of Medium: Online Resource
    ISSN: 0940-5429 , 1432-5233
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2010
    detail.hit.zdb_id: 1468518-8
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  • 2
    In: Pest Management Science, Wiley, Vol. 75, No. 12 ( 2019-12), p. 3160-3166
    Abstract: Strobilurin fungicides are some of the most potent and successful agrochemicals. However, continued use of traditional strobilurins has led to the emergence of fungicide‐resistant biotypes. Thus, a supply of new strobilurin fungicides is highly valuable. In this study, a series of novel methoxyacrylate analogs containing a cyano‐substituted hydrazine moiety as the side chain was synthesized and evaluated for their anti‐plant pathogenic activities. RESULTS Compounds 2‐04 , 2‐05 , 2‐07 and 2‐14 exhibited a relatively broad range of fungicidal activity. Compounds 2‐04 , 2‐13 and 2‐14 exhibited good fungicidal activity against Sclerotinia sclerotiorum with median effective concentrations (EC 50 ) of 3.84, 3.50 and 3.80 μg mL −1 , respectively. Most of these compounds showed excellent inhibition of spore germination in Magnaporthe grisea at 25 μg mL −1 . Moreover, in an in vivo test, compounds 2‐02 , 2‐04 , 2‐07 and 2‐13 exhibited potent fungicidal activities against the tested plant diseases at 400 μg mL −1 . Notably, compound 2‐07 showed comparable or better activity than the commercially positive controls, azoxystrobin and procloraz, against powdery mildew of cucumber and rice blast fungus in the field trails at the same application dosages. CONCLUSON This study indicated that methoxyacrylate analogs containing a cyano‐substituted hydrazone side chain can serve as potential fungicidal candidates for crop protection. © 2019 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Bioscientifica ; 2018
    In:  Endocrine Connections Vol. 7, No. 12 ( 2018-12), p. 1315-1321
    In: Endocrine Connections, Bioscientifica, Vol. 7, No. 12 ( 2018-12), p. 1315-1321
    Abstract: Autoimmune thyroiditis (AIT) is the most common autoimmune thyroid disease. Longitudinal relaxation time mapping (T1-mapping) measured by MRI is a new technique for assessing interstitial fibrosis of some organs, such as heart and liver. This study aimed to evaluate the relationship between T1-mapping value and thyroid function and determine the usefulness of T1-mapping in identifying thyroid destruction in AIT patients. Methods This case–control study recruited 57 drug-naïve AIT patients and 17 healthy controls. All participants were given thyroid MRI, and T1-mapping values were measured using a modified look-locker inversion-recovery sequence. Results AIT patients had significantly higher thyroid T1-mapping values than the healthy controls (1.077 ± 177 vs 778 ± 82.9 ms; P   〈  0.01). A significant increase in thyroid T1-mapping values was presented along with the increased severity of thyroid dysfunction ( P   〈  0.01). Correlation analyses showed that increased thyroid T1-mapping values were associated with higher TSH and lower FT3 and FT4 levels (TSH: r  = 0.75; FT3: r  = −0.47; FT4: r  = −0.72; all P   〈  0.01). Receiver-operating characteristic curve analysis revealed a high diagnostic value of T1-mapping values for the degree of thyroid destruction (area under the curve was 0.95, 95% CI: 0.90–0.99, P   〈  0.01). Conclusions AIT patients have higher thyroid T1-mapping values than the healthy controls, and the T1-mapping values increased with the progression of thyroid dysfunction. Thyroid T1-mapping value might be a new index to quantitatively evaluate the degree of thyroid destruction in AIT patients.
    Type of Medium: Online Resource
    ISSN: 2049-3614
    Language: Unknown
    Publisher: Bioscientifica
    Publication Date: 2018
    detail.hit.zdb_id: 2668428-7
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  • 4
    Online Resource
    Online Resource
    Hindawi Limited ; 2021
    In:  International Journal of Endocrinology Vol. 2021 ( 2021-11-18), p. 1-8
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2021 ( 2021-11-18), p. 1-8
    Abstract: Objective. Irisin, a novel myokine, has recently been considered to produce a cardioprotective effect. Potential biomarkers for myocardial injuries in patients with severe hypothyroidism have yet to be identified. We aimed to investigate whether serum irisin may serve as a promising biomarker for early detecting the myocardial injuries in patients with severe hypothyroidism. Methods. This cross-sectional study comprised 25 newly diagnosed drug-naive patients with severe primary hypothyroidism and 17 age- and sex-matched healthy controls. Circulating irisin levels and cardiac magnetic resonance (CMR) were evaluated in each participant. Left ventricular (LV) myocardial injuries were detected by CMR-based T1 mapping technique using a modified look-locker inversion recovery (MOLLI) sequence, which is quantified as native T1 values. Results. Compared with healthy controls, the severe hypothyroidism group had significantly lower levels of serum irisin, especially those with pericardial effusion ( P 〈 0.05 ). The severe hypothyroidism subjects exhibited lower peak filling rates (PFRs) and higher native myocardial T1 values than controls ( P 〈 0.05 ). Additionally, the ROC analysis displayed that the sensitivity and specificity of serum irisin for diagnosing pericardial effusion in patients with severe hypothyroidism were 73.3% and 100.0%, respectively. The AUC was 0.920 (0.861–1.000) ( P 〈 0.001 ). The cutoff value was 36.94 ng/mL. Moreover, the results in subgroup analysis revealed that the native T1 values of the low-irisin group were significantly higher than that of the high-irisin group ( P 〈 0.05 ). According to multivariate linear regression analysis, serum irisin concentrations were negatively and independently correlated with native myocardial T1 values after adjustment for age, sex, and other conventional confounding factors (β = −1.473, P 〈 0.05 ). Conclusions. Irisin may be a potential biomarker for predicting myocardial injuries in patients with severe hypothyroidism.
    Type of Medium: Online Resource
    ISSN: 1687-8345 , 1687-8337
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2502951-4
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  • 5
    Online Resource
    Online Resource
    Hindawi Limited ; 2017
    In:  International Journal of Endocrinology Vol. 2017 ( 2017), p. 1-6
    In: International Journal of Endocrinology, Hindawi Limited, Vol. 2017 ( 2017), p. 1-6
    Abstract: Aims . The present study assessed the therapeutic effect of exenatide and metformin as the initial therapy on overweight/obese patients with newly diagnosed type 2 diabetes (T2D). Methods . The prospective, nonrandomized, interventional study enrolled a total of 230 overweight or obese patients with newly diagnosed T2D who were administrated exenatide or metformin hydrochloride for 12 weeks. Results . 224/230 patients, including 106 in the exenatide group and 118 in the metformin group, completed the 12-week treatment. Both exenatide and metformin significantly decreased the HbA1c levels in overweight/obese patients with newly diagnosed T2D (all P 〈 0.05 ). The reduction in HbA1c and the proportion of patients with HbA1c  〈  7.0% (53 mmol/mol) were higher in the exenatide group than in the metformin group (all P 〈 0.05 ). The exenatide treatment caused a greater decline in the body weight and BMI as compared to the metformin treatment (all P 〈 0.01 ). The exenatide treatment ( β  = 0.41, P 〈 0.01 ) and baseline HbA1c level ( β  = −0.84, P 〈 0.01 ) were independent influencing factors for the decrease in HbA1c level. Conclusions . For an initial therapy in overweight/obese patients with newly diagnosed T2D, exenatide causes a better glycemic control than metformin. This trial is registered with NCT03297879 .
    Type of Medium: Online Resource
    ISSN: 1687-8337 , 1687-8345
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2502951-4
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2015
    In:  Diabetes/Metabolism Research and Reviews Vol. 31, No. 4 ( 2015-05), p. 329-335
    In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 31, No. 4 ( 2015-05), p. 329-335
    Abstract: Non‐alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, and its incidence has been increasing recently. In addition to hepatic complications, NAFLD is also recognized as an independent risk factor for cardiovascular disease. Unfortunately, the current therapies for NAFLD display variable efficacy; a novel and effective drug is urgently needed. Glucagon‐like peptide‐1 (GLP‐1), a receptor agonist is a new drug approved for treating type 2 diabetes. Recently, these types of agents have shown a novel therapeutic effect on NAFLD. However, the mechanisms of GLP‐1 receptor agonists on the treatment of NAFLD have not yet been explained precisely. Recent studies have demonstrated that GLP‐1 reverses the progression of NAFLD not only indirectly through an incretin effect that improves key parameters involved in NAFLD, but also a direct effect on lipid metabolism of hepatocytes and inflammation in liver. In this review, we provided an overview of the role and mechanisms of GLP‐1 in the therapy of NAFLD. Copyright © 2014 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1520-7552 , 1520-7560
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2001565-3
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  • 7
    In: Endokrynologia Polska, VM Media Group sp. z o.o, Vol. 72, No. 6 ( 2021-12-30), p. 618-624
    Type of Medium: Online Resource
    ISSN: 2299-8306 , 0423-104X
    Language: Unknown
    Publisher: VM Media Group sp. z o.o
    Publication Date: 2021
    detail.hit.zdb_id: 2250456-4
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  • 8
    In: Chinese Physics C, IOP Publishing, Vol. 47, No. 11 ( 2023-11-01), p. 113002-
    Abstract: The Jiangmen Underground Neutrino Observatory (JUNO) is a large liquid scintillator detector designed to explore many topics in fundamental physics. In this study, the potential of searching for proton decay in the mode with JUNO is investigated. The kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for identification. Moreover, the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed signals. Based on these advantages, the detection efficiency for the proton decay via is 36.9% ± 4.9% with a background level of events after 10 years of data collection. The estimated sensitivity based on 200 kton-years of exposure is years, which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.
    Type of Medium: Online Resource
    ISSN: 1674-1137 , 2058-6132
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2491278-5
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  • 9
    In: Chinese Physics C, IOP Publishing, Vol. 45, No. 2 ( 2021-02-01), p. 023004-
    Abstract: The Jiangmen Underground Neutrino Observatory (JUNO) features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector. Some of JUNO's features make it an excellent location for B solar neutrino measurements, such as its low-energy threshold, high energy resolution compared with water Cherenkov detectors, and much larger target mass compared with previous liquid scintillator detectors. In this paper, we present a comprehensive assessment of JUNO's potential for detecting B solar neutrinos via the neutrino-electron elastic scattering process. A reduced 2 MeV threshold for the recoil electron energy is found to be achievable, assuming that the intrinsic radioactive background U and Th in the liquid scintillator can be controlled to 10 g/g. With ten years of data acquisition, approximately 60,000 signal and 30,000 background events are expected. This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter, which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework. If eV , JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3 (2 ) level by measuring the non-zero signal rate variation with respect to the solar zenith angle. Moreover, JUNO can simultaneously measure using B solar neutrinos to a precision of 20% or better, depending on the central value, and to sub-percent precision using reactor antineutrinos. A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of reported by solar neutrino experiments and the KamLAND experiment.
    Type of Medium: Online Resource
    ISSN: 1674-1137 , 2058-6132
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 2491278-5
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  • 10
    Online Resource
    Online Resource
    Universite Catholique de Louvain ; 2018
    In:  Exercise Biochemistry Review Vol. 1, No. 4 ( 2018-10-04)
    In: Exercise Biochemistry Review, Universite Catholique de Louvain, Vol. 1, No. 4 ( 2018-10-04)
    Abstract: Objective To study the effect of Chinese medicine Rhodiola on oxidative stress injury in amateur marathon runners after quantitative exercise load (20 km) and explore its mechanism. Methods Eight marathon amateurs were divided into four groups according to different test time, including before and after quantitative exercise load (group C and group CE), before and after quantitative exercise load after taking a month of the Rhodiola (group MC and group ME). The participants had serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC) and malondialdehyde (MDA), as well as myocardial enzyme index - creatine kinase (CK), lactate dehydrogenase (LDH), creatine kinase isoenzyme (CK-MB) and glutamic oxaline aminotransferase (AST/GOT) activity evaluated. In order to further explore the mechanism of action of Rhodiola, the urine was analyzed by 1H-HMR metabonomics technique. Results 1) Compared with group C, the activity of serum CK, LDH and AST/GOT of group CE increased significantly (P 〈 0.01 or P 〈 0.05), MDA content and SOD activity also increased significantly (P 〈 0.05). A total of fifteen potential biomarkers were found in group CE, such as valine, lactic acid, 2- hydroxy isobutyric acid and so on (P 〈 0.05 and VIP 〉 1). 2) Compared with group CE, the activity of serum CK and AST/GOT and the content of MDA of group ME decreased significantly (P 〈 0.05), eleven metabolites among the fifteen potential biomarkers reverted significantly (P 〈 0.01 or P 〈 0.05), which mainly involved in 4 metabolic pathways including alanine, aspartic acid and glutamic acid metabolism and so on. Conclusions Rhodiola can enhance the antioxidant capacity and improve myocardial damage of marathon amateurs after quantitative exercise load, which may be due to increased synthesis and utilization of aminoacyl-tRNA and other amino acids.
    Type of Medium: Online Resource
    ISSN: 2593-7588
    URL: Issue
    Language: Unknown
    Publisher: Universite Catholique de Louvain
    Publication Date: 2018
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