In:
Frontiers in Psychiatry, Frontiers Media SA, Vol. 13 ( 2022-4-14)
Abstract:
The interleukin-8 (IL-8) has been reported to play an important role in depression, which might be modulated by the selective serotonin reuptake inhibitors (SSRIs). Thus, the aim of this study was to investigate serum IL-8 levels, depressive symptom, and their associations in drug-free MDD patients, MDD patients with SSRIs, and healthy controls (HCs). Methods Fifty-seven drug-free MDD patients (male/female = 35/22, mean age: 39.24 years), 30 MDD patients with SSRIs (male/female = 11/19, mean age: 39.73 years), and 101 HCs (male/female = 52/49, mean age: 37.38 years) were recruited in this cross-sectional study. Serum IL-8 levels and depressive symptom were assessed using the Flow Cytometer and Hamilton Depression Scale (HAMD). The analysis of variance was used for the comparison between groups. The relationship between serum log 10 IL-8 levels and HAMD score was analyzed by Pearson correlation. Results Serum log 10 IL-8 levels were lower in all patients than HCs after controlling for covariates ( F = 4.86, p = 0.03). There was significant difference in serum Log 10 IL-8 levels among three groups after controlling for covariates ( F = 14.63, p & lt; 0.001). Serum Log 10 IL-8 levels in drug-free patients were lower compared to HCs ( F = 19.38, p & lt; 0.001) or patients with SSRIs ( F = 21.89, p & lt; 0.001) after controlling for covariates. However, there was not difference in serum log 10 IL-8 levels between patients with SSRIs and HCs after controlling for covariates. Moreover, serum Log 10 IL-8 levels were negatively correlated with HAMD score in all patients ( r = −0.37, p = 0.02). Also, serum Log 10 IL-8 levels were negatively correlated with HAMD score in drug-free patients ( r = −0.74, p = 0.01), but not in patients with SSRIs. Conclusion Our data supported that the decline in serum IL-8 levels was association with depression. Moreover, the SSRIs might modulate increased serum IL-8 levels of depression.
Type of Medium:
Online Resource
ISSN:
1664-0640
DOI:
10.3389/fpsyt.2022.858675
DOI:
10.3389/fpsyt.2022.858675.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2564218-2
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