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  • 1
    Online Resource
    Online Resource
    Large expert-curated database for benchmarking document similarity detection in biomedical literature search
    Oxford University Press (OUP) ; 2019
    In:  Database Vol. 2019 ( 2019-01-01)
    Details
    In: Database, Oxford University Press (OUP), Vol. 2019 ( 2019-01-01)
    Abstract: Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.
    Type of Medium: Online Resource
    ISSN: 1758-0463
    URL: Article
    DOI: 10.1093/database/baz085
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2496706-3
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  • 2
    Online Resource
    Online Resource
    Synthesis and Catalytic Properties of New Metalloporphyrin‐Based Porous Organic Framework Materials with Single and Accessible Sites
    Wiley ; 2016
    In:  ChemCatChem Vol. 8, No. 14 ( 2016-07-20), p. 2393-2400
    Details
    In: ChemCatChem, Wiley, Vol. 8, No. 14 ( 2016-07-20), p. 2393-2400
    Abstract: It is a big challenge to homogenize heterogeneous catalysts with molecular catalytic performance. With this target in mind, herein, we describe a facile strategy for direct incorporation of single catalytic sites in 3D open porous aromatic frameworks (PAFs). The synthesis of the PAF (denoted as PAF‐76) as well as its derivatives (PAF‐76‐M, M=Fe, Mn, Zn) was achieved by the use of tetrakis(4‐bromophenyl)methane as tetrahedral nodes and tetrakis(4‐bromophenyl)porphyrin as planar nodes. The connection of monomers into an extended network of PAF‐76 was monitored by 13 C NMR and FTIR spectroscopies. The prepared PAF‐76s showed 3D porous structures with surface areas of 450–700 m 2  g −1 , pore volumes of 0.3–0.4 cm 3  g −1 , and pore sizes around 1.2 nm. The direct incorporation of metalloporphyrin components into the PAF‐76‐M frameworks has allowed the uniform distribution of metal ionic sites throughout the PAF‐76‐M particles. The combined merits of isolated metal sites and suitable pore size make PAF‐76 a good candidate for heterogeneous catalysis. The catalytic performances of the porphyrin/metalloporphyrin‐based active sites in the PAF‐76s were evaluated by aerobic oxidation reactions of styrene, which are usually carried out with homogeneous systems. Metal‐functionalized PAF‐76s (PAF‐76‐M) exhibit enhanced turnover frequencies for styrene conversion (16.9–50.9 mol mol(M) −1  h −1 ) compared with molecular catalysts (0–35.0 mol mol(M) −1  h −1 ), and improved selectivity toward phenylacetaldehyde (85.7–99 %) in contrast to their corresponding monomers (0–75.5 %). The robustness of PAF‐76 in terms of high thermal stability, good recyclability, and excellent solvent resistance showed that these PAF‐76 materials hold great promise for developing heterogeneous catalysts.
    Type of Medium: Online Resource
    ISSN: 1867-3880 , 1867-3899
    URL: Issue
    URL: Article
    DOI: 10.1002/cctc.v8.14
    DOI: 10.1002/cctc.201600462
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2485108-5
    detail.hit.zdb_id: 2501161-3
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  • 3
    Online Resource
    Online Resource
    Natural Gas Hydrate Decomposition Characteristics at the Exploitation Anaphase via Sediment Warming
    American Chemical Society (ACS) ; 2024
    In:  Energy & Fuels Vol. 38, No. 15 ( 2024-08-01), p. 14334-14342
    Details
    In: Energy & Fuels, American Chemical Society (ACS), Vol. 38, No. 15 ( 2024-08-01), p. 14334-14342
    Type of Medium: Online Resource
    ISSN: 0887-0624 , 1520-5029
    URL: Article
    DOI: 10.1021/acs.energyfuels.4c02709
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2024
    detail.hit.zdb_id: 56449-7
    detail.hit.zdb_id: 1483539-3
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  • 4
    Online Resource
    Online Resource
    Ivonescimab Plus Chemotherapy in Non–Small Cell Lung Cancer With EGFR Variant : A Randomized Clinical Trial
    American Medical Association (AMA) ; 2024
    In:  JAMA
    Details
    In: JAMA, American Medical Association (AMA)
    Abstract: For patients with non–small cell lung cancer whose disease progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, particularly third-generation TKIs, optimal treatment options remain limited. Objective To compare the efficacy of ivonescimab plus chemotherapy with chemotherapy alone for patients with relapsed advanced or metastatic non–small cell lung cancer with the epidermal growth factor receptor ( EGFR ) variant. Design, Setting, and Participants Double-blind, placebo-controlled, randomized, phase 3 trial at 55 sites in China enrolled participants from January 2022 to November 2022; a total of 322 eligible patients were enrolled. Interventions Participants received ivonescimab (n = 161) or placebo (n = 161) plus pemetrexed and carboplatin once every 3 weeks for 4 cycles, followed by maintenance therapy of ivonescimab plus pemetrexed or placebo plus pemetrexed. Main Outcomes and Measures The primary end point was progression-free survival in the intention-to-treat population assessed by an independent radiographic review committee (IRRC) per Response Evaluation Criteria in Solid Tumors version 1.1. The results of the first planned interim analysis are reported. Results Among 322 enrolled patients in the ivonescimab and placebo groups, the median age was 59.6 vs 59.4 years and 52.2% vs 50.9% of patients were female. As of March 10, 2023, median follow-up time was 7.89 months. Median progression-free survival was 7.1 (95% CI, 5.9-8.7) months in the ivonescimab group vs 4.8 (95% CI, 4.2-5.6) months for placebo (difference, 2.3 months; hazard ratio [HR], 0.46 [95% CI, 0.34-0.62] ; P   & amp;lt; .001). The prespecified subgroup analysis showed progression-free survival benefit favoring patients receiving ivonescimab over placebo across almost all subgroups, including patients whose disease progressed while receiving third-generation EGFR-TKI therapy (HR, 0.48 [95% CI 0.35-0.66]) and those with brain metastases (HR, 0.40 [95% CI, 0.22-0.73] ). The objective response rate was 50.6% (95% CI, 42.6%-58.6%) with ivonescimab and 35.4% (95% CI, 28.0%-43.3%) with placebo (difference, 15.6% [95% CI, 5.3%-26.0%]; P  = .006). The median overall survival data were not mature; at data cutoff, 69 patients (21.4%) had died. Grade 3 or higher treatment-emergent adverse events occurred in 99 patients (61.5%) in the ivonescimab group vs 79 patients (49.1%) in the placebo group, the most common of which were chemotherapy-related. Grade 3 or higher immune-related adverse events occurred in 10 patients (6.2%) in the ivonescimab group vs 4 (2.5%) in the placebo group. Grade 3 or higher vascular endothelial growth factor–related adverse events occurred in 5 patients (3.1%) in the ivonescimab group vs 4 (2.5%) in the placebo group. Conclusions Ivonescimab plus chemotherapy significantly improved progression-free survival with tolerable safety profile in TKI-treated non–small cell lung cancer. Trial Registration ClinicalTrials.gov Identifier: NCT05184712
    Type of Medium: Online Resource
    ISSN: 0098-7484
    URL: Article
    DOI: 10.1001/jama.2024.10613
    RVK:
    XA 10000
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2024
    detail.hit.zdb_id: 2958-0
    SSG: 5,21
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  • 5
    Online Resource
    Online Resource
    E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines
    Impact Journals, LLC ; 2015
    In:  Oncotarget Vol. 6, No. 27 ( 2015-09-15), p. 23930-23943
    Details
    In: Oncotarget, Impact Journals, LLC, Vol. 6, No. 27 ( 2015-09-15), p. 23930-23943
    Type of Medium: Online Resource
    ISSN: 1949-2553
    URL: Issue
    URL: Article
    DOI: 10.18632/oncotarget.v6i27
    DOI: 10.18632/oncotarget.4525
    Language: English
    Publisher: Impact Journals, LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2560162-3
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  • 6
    Online Resource
    Online Resource
    The enhanced role of surface amination on the catalytic performance of polyacrylonitrile supported palladium nanoparticles in hydrogen generation from formic acid
    Wiley ; 2021
    In:  Journal of Applied Polymer Science Vol. 138, No. 20 ( 2021-05-20)
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 138, No. 20 ( 2021-05-20)
    Abstract: Hydrogen production by formic acid (FA) has attracted widespread attention in the field of catalysis and energy chemistry. Here, we develop a highly efficient catalyst for FA dehydrogenation by surface amination of polyacrylonitrile (PAN) supported palladium nanoparticles (Pd NPs). The support of PAN derived from a soap‐free emulsion polymerization was ammoniated by simply treating it with ethylenediamine (EDA) solution under heating. Compared with the parent PAN material, the aminated PAN (EDA‐PAN) is a more suitable support to achieve high dispersion of Pd NPs with ultra‐small particle size (around 1.2 nm), and to fabricate more active and stable supported Pd‐based catalyst for FA dehydrogenation. The turnover frequency (TOF) of the Pd/EDA‐PAN catalyst could reach to 3989 h −1 at 333 K without using any additional bases or additives. More significantly, the aminated catalyst could even work well at ambient temperature with a TOF of 688 h −1 at 303 K.
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v138.20
    DOI: 10.1002/app.50456
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 240694-9
    detail.hit.zdb_id: 1491105-X
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  • 7
    Online Resource
    Online Resource
    Electrochemical Synthesis and Catalytic Properties of Encapsulated Metal Clusters within Zeolitic Imidazolate Frameworks
    Wiley ; 2016
    In:  Chemistry – A European Journal Vol. 22, No. 46 ( 2016-11-07), p. 16613-16620
    Details
    In: Chemistry – A European Journal, Wiley, Vol. 22, No. 46 ( 2016-11-07), p. 16613-16620
    Abstract: It is very interesting and also a big challenge to encapsulate metal clusters within microporous solids to expand their application diversity. For this target, herein, we present an electrochemical synthesis strategy for the encapsulation of noble metals (Au, Pd, Pt) within ZIF‐8 cavities. In this method, metal precursors of AuCl 4 2− , PtCl 6 2− , and PdCl 4 2− are introduced into ZIF‐8 crystals during the concurrent crystallization of ZIF‐8 at the anode. As a consequence, very small metal clusters with sizes around 1.2 nm are obtained within ZIF‐8 crystals after hydrogen reduction; these clusters exhibit high thermal stability, as evident from the good maintenance of their original sizes after a high‐temperature test. The catalytic properties of the encapsulated metal clusters within ZIF‐8 are evaluated for CO oxidations. Because of the small pore window of ZIF‐8 (0.34 nm) and the confinement effect of small pores, about 80 % of the metal clusters (fractions of 0.74, 0.77, and 0.75 for Au, Pt, and Pd in ZIF‐8, respectively) retain their catalytic activity after exposure to the organosulfur poison thiophene (0.46 nm), which is in contrast to their counterparts (fractions of 0.22, 0.25, and 0.20 for Au, Pt, and Pd on the SiO 2 support). The excellent performances of metal clusters encapsulated within ZIF‐8 crystals give new opportunities for catalytic reactions.
    Type of Medium: Online Resource
    ISSN: 0947-6539 , 1521-3765
    URL: Issue
    URL: Article
    DOI: 10.1002/chem.v22.46
    DOI: 10.1002/chem.201602924
    RVK:
    VA 3507
    RVK:
    VA 1120
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1478547-X
    detail.hit.zdb_id: 1231884-X
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  • 8
    Online Resource
    Online Resource
    Effects of nozzle diameter on marine fuel injection and deflagration performance
    AIP Publishing ; 2024
    In:  Physics of Fluids Vol. 36, No. 7 ( 2024-07-01)
    Details
    In: Physics of Fluids, AIP Publishing, Vol. 36, No. 7 ( 2024-07-01)
    Abstract: The marine fuel injection and deflagration performance with different nozzle diameters in large compartments are researched in this work. The results show that marine fuel could quickly form a stable fuel spray field. Increasing nozzle diameter dramatically enhances the fuel spray concentration and aggravates the fuel spray deflagration degree, resulting in rapid increases in flame propagation speed, deflagration overpressure, and deflagration temperature. A larger nozzle diameter causes the deflagration flame to propagate further forward. With the increase of deflagration time, the flame propagation speed shows a trend of first rising and then decreasing, with fluctuations. When the nozzle diameter is small, the overpressure declines toward the back. In the case of large nozzles (≥0.8 mm), the overpressure distribution in the compartment fluctuates greatly, with a tendency to increase first and then decrease. Furthermore, deflagration peak overpressure ascends linearly with the logarithm of fuel spray concentration. The peak deflagration overpressure is 1.875 MPa with 1.0 mm nozzle diameter. The deflagration temperature is highest at the center of the deflagration. The research results can guide the assessment and prevention of fire and deflagration accidents on ships.
    Type of Medium: Online Resource
    ISSN: 1070-6631 , 1089-7666
    URL: Article
    DOI: 10.1063/5.0211633
    Language: English
    Publisher: AIP Publishing
    Publication Date: 2024
    detail.hit.zdb_id: 1472743-2
    detail.hit.zdb_id: 241528-8
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  • 9
    Online Resource
    Online Resource
    De novo genes with an lncRNA origin encode unique human brain developmental functionality
    Springer Science and Business Media LLC ; 2023
    In:  Nature Ecology & Evolution Vol. 7, No. 2 ( 2023-01-02), p. 264-278
    Details
    In: Nature Ecology & Evolution, Springer Science and Business Media LLC, Vol. 7, No. 2 ( 2023-01-02), p. 264-278
    Abstract: Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and are evolutionarily significant in general, yet how and why this all-or-nothing transition to functionality happens remains unclear. Here, in 74 human/hominoid-specific de novo genes, we identified distinctive U1 elements and RNA splice-related sequences accounting for RNA nuclear export, differentiating mRNAs from lncRNAs, and driving the origin of de novo genes from lncRNA loci. The polymorphic sites facilitating the lncRNA–mRNA conversion through regulating nuclear export are selectively constrained, maintaining a boundary that differentiates mRNAs from lncRNAs. The functional new genes actively passing through it thus showed a mode of pre-adaptive origin, in that they acquire functions along with the achievement of their coding potential. As a proof of concept, we verified the regulations of splicing and U1 recognition on the nuclear export efficiency of one of these genes, the ENSG00000205704 , in human neural progenitor cells. Notably, knock-out or over-expression of this gene in human embryonic stem cells accelerates or delays the neuronal maturation of cortical organoids, respectively. The transgenic mice with ectopically expressed ENSG00000205704 showed enlarged brains with cortical expansion. We thus demonstrate the key roles of nuclear export in de novo gene origin. These newly originated genes should reflect the novel uniqueness of human brain development.
    Type of Medium: Online Resource
    ISSN: 2397-334X
    URL: Article
    DOI: 10.1038/s41559-022-01925-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2879715-2
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  • 10
    Online Resource
    Online Resource
    Flame expansion behavior induced by a water droplet impacting on burning and stratified oil-water pool
    Elsevier BV ; 2023
    In:  International Journal of Thermal Sciences Vol. 191 ( 2023-09), p. 108342-
    Details
    In: International Journal of Thermal Sciences, Elsevier BV, Vol. 191 ( 2023-09), p. 108342-
    Type of Medium: Online Resource
    ISSN: 1290-0729
    URL: Article
    DOI: 10.1016/j.ijthermalsci.2023.108342
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 1469245-4
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