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  • 1
    Online Resource
    Online Resource
    Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022
    Oxford University Press (OUP) ; 2022
    In:  Nucleic Acids Research Vol. 50, No. D1 ( 2022-01-07), p. D27-D38
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 50, No. D1 ( 2022-01-07), p. D27-D38
    Abstract: The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support global research in both academia and industry. With the explosively accumulated multi-omics data at ever-faster rates, CNCB-NGDC is constantly scaling up and updating its core database resources through big data archive, curation, integration and analysis. In the past year, efforts have been made to synthesize the growing data and knowledge, particularly in single-cell omics and precision medicine research, and a series of resources have been newly developed, updated and enhanced. Moreover, CNCB-NGDC has continued to daily update SARS-CoV-2 genome sequences, variants, haplotypes and literature. Particularly, OpenLB, an open library of bioscience, has been established by providing easy and open access to a substantial number of abstract texts from PubMed, bioRxiv and medRxiv. In addition, Database Commons is significantly updated by cataloguing a full list of global databases, and BLAST tools are newly deployed to provide online sequence search services. All these resources along with their services are publicly accessible at https://ngdc.cncb.ac.cn.
    Type of Medium: Online Resource
    ISSN: 0305-1048 , 1362-4962
    URL: Article
    DOI: 10.1093/nar/gkab951
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2023
    Oxford University Press (OUP) ; 2023
    In:  Nucleic Acids Research Vol. 51, No. D1 ( 2023-01-06), p. D18-D28
    Details
    In: Nucleic Acids Research, Oxford University Press (OUP), Vol. 51, No. D1 ( 2023-01-06), p. D18-D28
    Abstract: The National Genomics Data Center (NGDC), part of the China National Center for Bioinformation (CNCB), provides a family of database resources to support global academic and industrial communities. With the explosive accumulation of multi-omics data generated at an unprecedented rate, CNCB-NGDC constantly expands and updates core database resources by big data archive, integrative analysis and value-added curation. In the past year, efforts have been devoted to integrating multiple omics data, synthesizing the growing knowledge, developing new resources and upgrading a set of major resources. Particularly, several database resources are newly developed for infectious diseases and microbiology (MPoxVR, KGCoV, ProPan), cancer-trait association (ASCancer Atlas, TWAS Atlas, Brain Catalog, CCAS) as well as tropical plants (TCOD). Importantly, given the global health threat caused by monkeypox virus and SARS-CoV-2, CNCB-NGDC has newly constructed the monkeypox virus resource, along with frequent updates of SARS-CoV-2 genome sequences, variants as well as haplotypes. All the resources and services are publicly accessible at https://ngdc.cncb.ac.cn.
    Type of Medium: Online Resource
    ISSN: 0305-1048 , 1362-4962
    URL: Article
    DOI: 10.1093/nar/gkac1073
    RVK:
    WA 15000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2023
    detail.hit.zdb_id: 1472175-2
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way
    BMJ ; 2022
    In:  Journal for ImmunoTherapy of Cancer Vol. 10, No. 10 ( 2022-10), p. e004590-
    Details
    In: Journal for ImmunoTherapy of Cancer, BMJ, Vol. 10, No. 10 ( 2022-10), p. e004590-
    Abstract: Various tumors are insensitive to immune checkpoint blockade (ICB) therapy. Toll-like receptors (TLRs) establish the link between innate and adaptive immunity, which can assist T-cell activation and serve as promising targets for combination to enhance ICB therapy. Here, we aimed to improve efficacy for anti-programmed death ligand 1 (PD-L1) therapy by developing a PD-L1/TLR7 dual-targeting nanobody-drug conjugate (NDC), based on the PD-L1 nanobodies and TLR7 agonist we developed. Methods PD-L1 nanobodies were obtained by phage display screening and identified through T-cell activation bioassay, in vivo imaging and quantitative biodistribution study. Immune activation and PD-L1-inducing of TLR7 agonists were evaluated in diverse innate cell models. We constructed PD-L1/TLR7 dual-targeting NDCs by chemically coupling PD-L1 nanobodies and TLR7 agonists. The antitumor effect was evaluated via several murine or humanized solid tumor models. Immunophenotyping, immune cell depletion, tumor rechallenge, RNA sequencing and PD-L1-deficient models were combined to determine the mechanism for NDCs function. The dynamics of the in vivo behaviors of NDCs were assessed based on multiorgan changes in PD-L1 levels. Results The screened PD-L1 nanobodies were characterized as tumor-targeting and alleviated T-cell immunosuppression. The TLR7 agonists induced broad innate immune responses and intratumoral PD-L1 expression on antigen-presenting cells (APCs), and its antitumor effect was dependent on intratumoral delivery. The combination of TLR7 agonists and PD-L1 nanobodies activated both innate and adaptive immunity and upregulated PD-L1-related signaling pathways. After coupling to form dual-targeting NDCs, TLR7 agonists and PD-L1 nanobodies exerted synergistic antitumor effects and safety in either ‘hot’ or ‘cold’ tumor and early or advanced tumor models, reshaped the tumor immune microenvironment and induced antitumor immune memory. CD8 + T cells and natural killer cells were the main effector cells for NDCs to function. NDCs can promote PD-L1 expression on intratumoral APCs and tumor cells, and subsequently achieve targeted enrichment in tumors. Moreover, the efficacy of NDCs is biased toward dependence on host expression of PD-L1. Conclusions The novel PD-L1/TLR7 dual-targeting NDC exhibited potent efficacy against heterogeneous tumors through orchestrating innate and adaptive immunity, which could act as a promising strategy to improve ICB therapy and shows prospects for clinical development.
    Type of Medium: Online Resource
    ISSN: 2051-1426
    URL: Article
    DOI: 10.1136/jitc-2022-004590
    Language: English
    Publisher: BMJ
    Publication Date: 2022
    detail.hit.zdb_id: 2719863-7
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  • 4
    Online Resource
    Online Resource
    Giant photonic spin Hall effect induced by hyperbolic shear polaritons
    Royal Society of Chemistry (RSC) ; 2023
    In:  Physical Chemistry Chemical Physics Vol. 25, No. 16 ( 2023), p. 11245-11252
    Details
    In: Physical Chemistry Chemical Physics, Royal Society of Chemistry (RSC), Vol. 25, No. 16 ( 2023), p. 11245-11252
    Abstract: Recently, broken symmetry within crystals has been attracting tremendous research interest since it can be utilized to effectively manipulate the propagation of photons. In particular, low-symmetry Bravais crystals can support hyperbolic shear polaritons (HShPs), holding great promise for technological upgrading in the emerging research area of spinoptics. Herein, an Otto-type multilayer structure consisting of a KRS5 prism, a sensing medium, and monoclinic β-Ga 2 O 3 crystals is designed to ameliorate the photonic spin Hall effect (PSHE). The surface of β-Ga 2 O 3 is the monoclinic (010) plane ( x – y plane). We show that giant spin Hall shifts with three (or two) orders of magnitude of the incident wavelength can be obtained in the in-plane (or transverse) directions. The azimuthal dispersions of photonic spin Hall shifts present non-mirror-symmetric patterns upon tuning the rotation angle of β-Ga 2 O 3 around the z -axis in the plane. All of these exotic optical properties are closely correlated with the broken crystal lattice symmetry and the incurred excitation of HShPs in monoclinic β-Ga 2 O 3 crystals. By virtue of the remarkably enhanced PSHE, our proposed Otto-type multilayer structure shows a superior biosensing performance in which the maximum sensitivity is two orders of magnitude larger than that of previously reported PSHE biosensors based on two-dimensional materials. In addition, the optimized physical and structural parameters including the incident angle, excitation wavelength, azimuth angle and doping concentration of β-Ga 2 O 3 , thickness and refractive index of sensing medium are also investigated and presented. This work unequivocally confirms the strong influence of crystal symmetry on the PSHE, providing important insights into understanding the rich modulation of spin–orbit interactions of light via shear polaritons and therefore facilitating potential applications in photoelectronic devices.
    Type of Medium: Online Resource
    ISSN: 1463-9076 , 1463-9084
    URL: Article
    DOI: 10.1039/D3CP00205E
    Language: English
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 2023
    detail.hit.zdb_id: 1476283-3
    detail.hit.zdb_id: 1476244-4
    detail.hit.zdb_id: 1460656-2
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  • 5
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    Chinese expert consensus on conversion therapy for hepatocellular carcinoma (2021 edition)
    AME Publishing Company ; 2022
    In:  Hepatobiliary Surgery and Nutrition Vol. 11, No. 2 ( 2022-4), p. 227-252
    Details
    In: Hepatobiliary Surgery and Nutrition, AME Publishing Company, Vol. 11, No. 2 ( 2022-4), p. 227-252
    Type of Medium: Online Resource
    ISSN: 2304-3881 , 2304-389X
    URL: Journal
    URL: Article
    DOI: 10.21037/hbsn
    DOI: 10.21037/hbsn-21-328
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2022
    detail.hit.zdb_id: 2812398-0
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  • 6
    Online Resource
    Online Resource
    Multiple forms of vitamin B6 regulate salt tolerance by balancing ROS and abscisic acid levels in maize root
    Springer Science and Business Media LLC ; 2022
    In:  Stress Biology Vol. 2, No. 1 ( 2022-09-19)
    Details
    In: Stress Biology, Springer Science and Business Media LLC, Vol. 2, No. 1 ( 2022-09-19)
    Abstract: Salt stress causes osmotic stress, ion toxicity and oxidative stress, inducing the accumulation of abscisic acid (ABA) and excessive reactive oxygen species (ROS) production, which further damage cell structure and inhibit the development of roots in plants. Previous study showed that vitamin B 6 (VB 6 ) plays a role in plant responses to salt stress, however, the regulatory relationship between ROS, VB 6 and ABA under salt stress remains unclear yet in plants. In our study, we found that salt stress-induced ABA accumulation requires ROS production, in addition, salt stress also promoted VB 6 (including pyridoxamine (PM), pyridoxal (PL), pyridoxine (PN), and pyridoxal 5′-phosphate (PLP)) accumulation, which involved in ROS scavenging and ABA biosynthesis. Furthermore, VB 6 -deficient maize mutant small kernel2 ( smk2 ) heterozygous is more susceptible to salt stress, and which failed to scavenge excessive ROS effectively or induce ABA accumulation in maize root under salt stress, interestingly, which can be restored by exogenous PN and PLP, respectively. According to these results, we proposed that PN and PLP play an essential role in balancing ROS and ABA levels under salt stress, respectively, it laid a foundation for VB 6 to be better applied in crop salt resistance than ABA.
    Type of Medium: Online Resource
    ISSN: 2731-0450
    URL: Article
    DOI: 10.1007/s44154-022-00061-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 3093255-5
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  • 7
    Online Resource
    Online Resource
    Photoluminescence and reflectivity of polymethylmethacrylate implanted by low-energy carbon ions at high fluences
    Elsevier BV ; 2012
    In:  Applied Surface Science Vol. 261 ( 2012-11), p. 653-658
    Details
    In: Applied Surface Science, Elsevier BV, Vol. 261 ( 2012-11), p. 653-658
    Type of Medium: Online Resource
    ISSN: 0169-4332
    URL: Article
    DOI: 10.1016/j.apsusc.2012.08.076
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 2002520-8
    detail.hit.zdb_id: 52886-9
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  • 8
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    Online Resource
    Effect of macroscopic defects on optical properties of fluorophosphate glasses
    IOP Publishing ; 2023
    In:  Journal of Physics: Conference Series Vol. 2557, No. 1 ( 2023-07-01), p. 012080-
    Details
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 2557, No. 1 ( 2023-07-01), p. 012080-
    Abstract: Fluorophosphate glass is the core of laser materials and also has an important reference value for an optical lens. According to Kirchhoff’s law, this paper focuses on the optical loss of incident light entering fluorophosphate glass. The transmittance and refractive index of optical glass were measured by an ultraviolet-visible spectrophotometer (Uv) and V-prism tester. With the sample thickness increasing from 10 mm to 50 mm, the transmittance of grade 4 fluorophosphate glass decreases from 85.32 % to 76.91 %, and the scattering rate increases from 8.4704 % to 17.0591 %. The microstructure and internal images of macroscopic defects were obtained by projective optical microscopy. In addition, an electron probe (EPMA) was used to analyze the defective components and identify the main components of the defects. The results show that the high content of P/Al/O element is the main cause of optical loss.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    URL: Article
    DOI: 10.1088/1742-6596/2557/1/012080
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2166409-2
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  • 9
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    Online Resource
    Research on Preparation and Luminescence Properties of Tm 3+ -doped Glass Ceramics Containing NaLa(MoO 4 ) 2
    IOP Publishing ; 2023
    In:  Journal of Physics: Conference Series Vol. 2499, No. 1 ( 2023-05-01), p. 012009-
    Details
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 2499, No. 1 ( 2023-05-01), p. 012009-
    Abstract: In the world of light-emitting diodes, Tm 3+ -doped glass ceramics are a crucial fluorescent material. In this study, melt-crystallization was used to create glass ceramics that were Tm 3+ -doped and included crystalline NaLa(MoO 4 ) 2 . X-ray diffraction (XRD), scanning electron microscopy (SEM), transmittance, and photoluminescence spectroscopy were used to examine the structure, morphology, and luminescence characteristics of glass ceramics (PL). According to the findings, keeping the precursor glass at 660 °C for two hours produced microcrystals with an average size of 280 nm. Also covered is how the concentration of Tm 2 O 3 doping affects the luminous characteristics of glass ceramics. The strongest blue light is produced at 454 nm ( 1 D 2 → 3 F 4 ) when Tm 2 O 3 concentration is 0.8 mol%. The findings demonstrate that Tm 3+ -doped glass ceramics containing NaLa(MoO 4 ) 2 crystalline phase have promise for use in the area of color displays.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    URL: Article
    DOI: 10.1088/1742-6596/2499/1/012009
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2166409-2
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  • 10
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    Online Resource
    Sign language translation system based on micro-inertial measurement units and ZigBee network
    SAGE Publications ; 2013
    In:  Transactions of the Institute of Measurement and Control Vol. 35, No. 7 ( 2013-10), p. 901-909
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 35, No. 7 ( 2013-10), p. 901-909
    Abstract: Chinese sign language has been proved as an effective communication tool for deaf people. In this paper, we present a novel translation system, which can capture human gestures through micro-inertial measurement units (IMUs) and translate the gestures into specific meanings accordingly. Each micro-IMU consists of a 3D accelerometer and gyroscope. A micro-controller and ZigBee network were used to acquire data simultaneously and wirelessly. Ten types of basic Chinese sign language movements including what, how, work, today, happy, please, book, body, clothes and and were collected and stored to form a motion-sensing database. A discrete cosine transform (DCT) was performed to extract the effective features from the original data, while a hidden Markov model (HMM) was used to train the database in order to form an HMM classifier. Testing samples were used to test the HMM classifier. Different sign languages were recognized through the HMM classifier and subsequent translation processes were performed. Experimental results showed that the correct recognition rate ranges from 95% to 100% for the 10 sign language movements, and the overall correction rate is 98%. With more micro-electro-mechanical system (MEMS) sensing motes adding to the interpretation system, the performance will be enhanced.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331212470962
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2025882-3
    SSG: 3,2
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