In:
Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 66, No. suppl_1 ( 2015-09)
Abstract:
Dysglycemia, proteinuria, vascular stiffness, diastolic dysfunction (DD) and hypertension are abnormalities seen more frequently in the obese, diabetic population. SGLT-2 inhibitors (SGLT-2i), which increase urinary glucose/sodium excretion to lower HbA1c and blood pressure (BP), are emerging as unique diabetes therapies. We examined whether the SGLT-2i, empagliflozin (EMPA), ameliorates hypertension, dysglycemia, proteinuria, aortic stiffness and DD in obese/diabetic female db/db mice. Eleven week old mice were fed a diet with or without EMPA (10mg/kg/day) for 5 weeks. In vivo blood pressure (telemetry), diastolic function (echo), aortic stiffness (pulse wave velocity, PWV), proteinuria, renal resistivity (echo) and HbA1c were evaluated. Db/db had elevated BP that was not affected by SGLT2i. HbA1c, proteinuria and the renal resistivity index (RI) were elevated (P 〈 0.001) in control (Db) mice vs treated mice (Db-EMPA) and lean control mice. Db exhibited DD that was ameliorated by SGLT2i as indicated by reduced LV filling pressure ( 〈 E/E’) and improved septal wall motion (E’/A’ ratio, not shown). Elevated PWV and aortic endothelial cell stiffness in Db-C were abrogated with SGLT2i. These results show that SGLT2i confers BP-independent cardiovascular and renal protective effects in obese diabetic female mice.
Type of Medium:
Online Resource
ISSN:
0194-911X
,
1524-4563
DOI:
10.1161/hyp.66.suppl_1.p233
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2015
detail.hit.zdb_id:
2094210-2
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