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  • 1
    Online Resource
    Online Resource
    Efficacy of mechanical/physical approaches for implant surface decontamination in non‐surgical submarginal instrumentation of peri‐implantitis. A systematic review
    Wiley ; 2023
    In:  Journal of Clinical Periodontology Vol. 50, No. S26 ( 2023-06), p. 188-211
    Details
    In: Journal of Clinical Periodontology, Wiley, Vol. 50, No. S26 ( 2023-06), p. 188-211
    Abstract: To evaluate the efficacy of non‐surgical submarginal peri‐implant instrumentation with mechanical/physical decontamination compared to non‐surgical submarginal instrumentation alone or with placebo decontamination in patients with peri‐implantitis. Materials and Methods Three focused questions were addressed, and a systematic search for randomized controlled clinical trials (RCTs), controlled clinical trials, and prospective cohort studies with definitions of peri‐implantitis and a minimal follow‐up of 6 months was conducted. The main outcome variables were reduction in pocket probing depth (PD) and bleeding on probing (BOP). Suppuration on probing, marginal peri‐implant bone level changes, patient‐related outcomes and adverse events, implant survival, treatment success, and disease resolution were assessed as secondary outcomes. Results Out of 239 findings, full‐text articles were assessed for eligibility, and 9 ( n  = 9 RCTs) were included in the present review. Five studies evaluated the effects of various laser types, and in four studies efficacy of air‐abrasive mechanisms and of a novel ultrasonic device was determined. At 6 months, PD reductions were observed in nine studies but only Er, Cr:YSGG laser‐treated group showed statistically significant higher reductions compared to the control group. BOP was statistically significantly reduced at 6 months in two studies following the application of Er:YAG laser compared to controls. One study reported statistically significant reduction in BOP following application of air‐polishing device compared to control treatment. No statistically significant differences between treatment groups were reported for the secondary outcome variables. Owing to the large heterogeneity of study designs, no meta‐analysis was performed. Conclusions Available evidence on the efficacy of non‐surgical submarginal peri‐implant instrumentation with mechanical/physical decontamination is limited by the small number of controlled studies and the high heterogeneity of study protocols. Clinical and patient‐reported benefits remain to be demonstrated.
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpe.v50.S26
    DOI: 10.1111/jcpe.13762
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2026349-1
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  • 2
    Online Resource
    Online Resource
    Antibiotics/antimicrobials: systemic and local administration in the therapy of mild to moderately advanced periodontitis
    Wiley ; 2016
    In:  Periodontology 2000 Vol. 71, No. 1 ( 2016-06), p. 82-112
    Details
    In: Periodontology 2000, Wiley, Vol. 71, No. 1 ( 2016-06), p. 82-112
    Abstract: This review gives an update of the current scientific evidence on the efficacy of the adjunctive use of systemic and local antibiotics/antimicrobials in the treatment of periodontitis. In particular, it addresses whether their use can improve the results of nonsurgical mechanical therapy in mild‐to‐moderate forms of the disease. Large numbers of randomized clinical trials and systematic reviews with meta‐analyses have clearly established that adjunctive systemic antibiotics, combined with mechanical debridement, offer clinical improvements additional to those obtained with scaling and root planing alone. These effects are more pronounced in aggressive periodontitis and in initially deep pockets, whereas more limited additional improvements, of 0.3 mm for additional pocket reduction and 0.2 mm for additional clinical attachment gain, have been documented for moderately deep sites (4–6 mm) in patients with chronic periodontitis. The marginal clinical benefit in patients with moderate disease has to be balanced against possible side effects. Notably, it has to be realized that an increasing number of warnings have been articulated against the unrestricted use of antibiotics in treating periodontal diseases because of the emerging global public health issue of bacterial resistance. The effects of the adjunctive local administration of antimicrobials have also been very well documented in several systematic reviews. Overall, in persistent or recurrent localized deep sites, the application of antimicrobials by sustained‐delivery devices may offer a benefit of an additional 0.4 mm in pocket depth reduction and 0.3 mm in clinical attachment level gain. In conclusion, the slight additional benefits of adjunctive antimicrobials, which were shown for moderate forms of periodontitis, have to be balanced against their side effects and therefore their prescription should be limited as much as possible.
    Type of Medium: Online Resource
    ISSN: 0906-6713 , 1600-0757
    URL: Issue
    URL: Article
    DOI: 10.1111/prd.2016.71.issue-1
    DOI: 10.1111/prd.12121
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2027098-7
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  • 3
    Online Resource
    Online Resource
    Complications and treatment errors related to regenerative periodontal surgery
    Wiley ; 2023
    In:  Periodontology 2000 Vol. 92, No. 1 ( 2023-06), p. 120-134
    Details
    In: Periodontology 2000, Wiley, Vol. 92, No. 1 ( 2023-06), p. 120-134
    Abstract: Regenerative periodontal surgical procedures are an important component in the treatment of advanced periodontitis. They aim to improve the long‐term prognosis of teeth that are periodontally compromised by the presence of intrabony and/or furcation defects, resulting biologically in formation of root cementum, periodontal ligament, and alveolar bone and evidenced clinically by reduction of deep pockets to maintainable probing depths and/or improvements of vertical and horizontal furcation depth. Over the last 25 years, substantial clinical evidence has been accumulated to support the value of regenerative procedures in periodontally compromised dentitions. However, treatment success requires close attention to certain factors on the level of the patient, the tooth/defect, and the operator. Ignoring these factors in case selection, treatment planning, and treatment execution will increase the risk of complications that may jeopardize clinical success and may even be considered as treatment errors. Based on the currently available evidence from clinical practice guidelines, treatment algorithms, and on expert opinion, the present article provides an overview on the main factors, which influence the outcomes of regenerative periodontal surgery and gives recommendations on how to prevent complications and treatment errors.
    Type of Medium: Online Resource
    ISSN: 0906-6713 , 1600-0757
    URL: Issue
    URL: Article
    DOI: 10.1111/prd.v92.1
    DOI: 10.1111/prd.12504
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2027098-7
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  • 4
    Online Resource
    Online Resource
    Management of a Central Incisor with Horizontal Root Fracture for Esthetic and Functional Rehabilitation
    Quintessence Publishing ; 2016
    In:  The International Journal of Periodontics & Restorative Dentistry Vol. 36, No. 1 ( 2016-01), p. 65-73
    Details
    In: The International Journal of Periodontics & Restorative Dentistry, Quintessence Publishing, Vol. 36, No. 1 ( 2016-01), p. 65-73
    Type of Medium: Online Resource
    ISSN: 0198-7569
    URL: Article
    DOI: 10.11607/prd.2338
    Language: Unknown
    Publisher: Quintessence Publishing
    Publication Date: 2016
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  • 5
    Online Resource
    Online Resource
    Vital root resection in severely furcation‐involved maxillary molars: Outcomes after up to 7 years
    Wiley ; 2020
    In:  Journal of Clinical Periodontology Vol. 47, No. 8 ( 2020-08), p. 970-979
    Details
    In: Journal of Clinical Periodontology, Wiley, Vol. 47, No. 8 ( 2020-08), p. 970-979
    Abstract: To introduce a novel therapeutic approach for the treatment of furcation‐involved maxillary molars by vital root resection and report longer‐term outcomes of a case series. Methods Eleven patients with 15 maxillary molars affected by double/triple class II ( n  = 10) or single/double class III ( n  = 5) furcation defects and advanced vertical bone loss around one root participated. Teeth were treated with deep pulpotomy using a calcium silicate‐based cement. After 4 weeks, the affected roots were removed by periodontal microsurgery and processed for histological evaluation of the pulp. All patients were enrolled into a supportive periodontal care programme. During the follow‐up period, assessments of tooth sensitivity, response to percussion, mobility, pocket probing depth (PPD) and bleeding on probing (BOP) were made, periapical radiographs obtained and patient‐reported outcomes collected. Results All teeth remained sensitive to pulp testing. After 1 year and 3–7 years of follow‐up, PD was ≤5 mm at all resected teeth. Furcation status was much improved. Neither increasing mobility nor clinical or radiographic signs of periapical pathology were observed throughout the individual observation period. All patients were pleased with the result of therapy. Histologic sections revealed a functional dentin‐pulp complex. Conclusions This case series demonstrates the possibility of maintaining severely furcation‐involved molars by vital root resection for up to 7 years. Root canal therapy and its associated costs and complications can thus be avoided.
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpe.v47.8
    DOI: 10.1111/jcpe.13306
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2026349-1
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  • 6
    Online Resource
    Online Resource
    Prevalence and antibiotic susceptibility trends of periodontal pathogens in the subgingival microbiota of German periodontitis patients: A retrospective surveillance study
    Wiley ; 2021
    In:  Journal of Clinical Periodontology Vol. 48, No. 9 ( 2021-09), p. 1216-1227
    Details
    In: Journal of Clinical Periodontology, Wiley, Vol. 48, No. 9 ( 2021-09), p. 1216-1227
    Abstract: This retrospective surveillance study aimed to follow periodontitis‐associated bacterial profiles and to identify time‐dependent changes in antibiotic susceptibility patterns. Materials and Methods From 2008 to 2015, bacterial specimen from deep periodontal pockets were collected from a total of 7804 German adults diagnosed with periodontitis. Presence of selected bacteria was confirmed by anaerobic culture and nucleic acid amplification. Antimicrobial susceptibility of clinical isolates was tested by disc diffusion with antibiotics used for the treatment of periodontitis and oral infections. The prevalences of periodontal pathogens were calculated and temporal evolution of antimicrobial susceptibility towards amoxicillin, amoxicillin/clavulanic acid, metronidazole, doxycycline, clindamycin, azithromycin, ciprofloxacin and ampicillin was analysed with logistic regression. Results The prevalence of patients harbouring bacteria was 95.9% Fusobacterium nucleatum , 88.0% Tannerella forsythia , 76.4% Treponema denticola , 76.5%, Campylobacter rectus , 76.0% Eikenella corrodens , 75.0% Capnocytophaga spp., 68.2% Porphyromonas gingivalis , 57.7% Peptostreptococcus micros , 43.1% Prevotella intermedia , 30.4% Eubacterium nodatum and 21.5% Aggregatibacter actinomycetemcomitans . In 63.5% of patients, one or more isolates were not susceptible to at least one of the antibiotics tested. The data further revealed a trend towards decreasing susceptibility profiles ( p 〈 0.05) with antibiotic non‐susceptibilities in 37% of patients in 2008 and in 70% in 2015. Conclusions The present study confirmed a high prevalence of periodontal pathogens in the subgingival microbiota of German periodontitis patients. The data revealed an incremental increase in isolates displaying resistance to some antibiotics but no relevant change in susceptibility to amoxicillin and metronidazole.
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Issue
    URL: Article
    DOI: 10.1111/jcpe.v48.9
    DOI: 10.1111/jcpe.13468
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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  • 7
    Online Resource
    Online Resource
    Clinical concepts for regenerative therapy in furcations
    Wiley ; 2015
    In:  Periodontology 2000 Vol. 68, No. 1 ( 2015-06), p. 308-332
    Details
    In: Periodontology 2000, Wiley, Vol. 68, No. 1 ( 2015-06), p. 308-332
    Abstract: Furcation involvements present one of the greatest challenges in periodontal therapy because furcation‐involved molar teeth respond less favorably to conventional periodontal therapy compared with noninvolved molar or nonmolar teeth. Various regenerative procedures have been proposed and applied with the aim of eliminating the furcation defect or reducing the furcation depth. An abundance of studies and several systematic reviews have established the effectiveness of membrane therapy (guided tissue regeneration) for buccal Class II furcation involvement of mandibular and maxillary molars compared with open flap surgery. Bone grafts/substitutes may enhance the results of guided tissue regeneration. However, complete furcation closure is not a predictable outcome. Limited data and no meta‐analyses are available on the effects of enamel matrix proteins for furcation regeneration. Enamel matrix protein therapy has demonstrated clinical improvements in the treatment of buccal Class II furcation defects in mandibular molars; however, complete closure of the furcation lesion is achieved only in a minority of cases. Neither guided tissue regeneration nor enamel matrix protein therapy have demonstrated predictable results for approximal Class II and for Class III furcations. Promising preclinical data from furcation regeneration studies in experimental animals is available for growth factor‐ and differentiation factor‐based technologies, but very limited data are available from human clinical studies. Although cell‐based therapies have received considerable attention in regenerative medicine, their experimental evaluation in the treatment of periodontal furcation lesions is at a very early stage of development. In summary, the indications and the limitations for currently available treatment modalities for furcation defects are well established. New regenerative treatments are clearly needed to improve the predictability of a complete resolution of furcation defects.
    Type of Medium: Online Resource
    ISSN: 0906-6713 , 1600-0757
    URL: Issue
    URL: Article
    DOI: 10.1111/prd.2015.68.issue-1
    DOI: 10.1111/prd.12081
    Language: English
    Publisher: Wiley
    Publication Date: 2015
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  • 8
    Online Resource
    Online Resource
    The Malaria Vaccine Candidate GMZ2 Elicits Functional Antibodies in Individuals From Malaria Endemic and Non-Endemic Areas
    Oxford University Press (OUP) ; 2013
    In:  The Journal of Infectious Diseases Vol. 208, No. 3 ( 2013-8-1), p. 479-488
    Details
    In: The Journal of Infectious Diseases, Oxford University Press (OUP), Vol. 208, No. 3 ( 2013-8-1), p. 479-488
    Type of Medium: Online Resource
    ISSN: 1537-6613 , 0022-1899
    URL: Article
    DOI: 10.1093/infdis/jit185
    RVK:
    XA 10000
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2013
    detail.hit.zdb_id: 1473843-0
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  • 9
    Online Resource
    Online Resource
    Reliability of probing depth assessments at healthy implant sites and natural teeth
    Springer Science and Business Media LLC ; 2022
    In:  Clinical Oral Investigations Vol. 27, No. 6 ( 2022-12-03), p. 2533-2545
    Details
    In: Clinical Oral Investigations, Springer Science and Business Media LLC, Vol. 27, No. 6 ( 2022-12-03), p. 2533-2545
    Type of Medium: Online Resource
    ISSN: 1436-3771
    URL: Article
    DOI: 10.1007/s00784-022-04810-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1472578-2
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  • 10
    Online Resource
    Online Resource
    Tratamento de um Incisivo Central com Fratura de Raiz para Reabilitação Estética e Funcional
    Editora Napoleao Ltda ME ; 2016
    In:  THE INTERNATIONAL JOURNAL OF PERIODONTICS AND RESTORATIVE DENTISTRY Vol. 01, No. 01 ( 2016-07-08), p. 194-
    Details
    In: THE INTERNATIONAL JOURNAL OF PERIODONTICS AND RESTORATIVE DENTISTRY, Editora Napoleao Ltda ME, Vol. 01, No. 01 ( 2016-07-08), p. 194-
    Type of Medium: Online Resource
    ISSN: 2448-4156
    URL: Article
    DOI: 10.20432/prd194
    Language: Unknown
    Publisher: Editora Napoleao Ltda ME
    Publication Date: 2016
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