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  • 1
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    Motion‐corrected simultaneous cardiac positron emission tomography and coronary MR angiography with high acquisition efficiency
    Wiley ; 2018
    In:  Magnetic Resonance in Medicine Vol. 79, No. 1 ( 2018-01), p. 339-350
    Details
    In: Magnetic Resonance in Medicine, Wiley, Vol. 79, No. 1 ( 2018-01), p. 339-350
    Abstract: Develop a framework for efficient free‐breathing simultaneous whole‐heart coronary magnetic resonance angiography (CMRA) and cardiac positron emission tomography (PET) on a 3 Tesla PET‐MR system. Methods An acquisition that enables nonrigid motion correction of both CMRA and PET has been developed. The proposed method estimates translational motion from low‐resolution 2D MR image navigators acquired at each heartbeat and 3D nonrigid respiratory motion between different respiratory bins from the CMRA data itself. Estimated motion is used for correcting the CMRA as well as the emission and attenuation PET data sets to the same respiratory position. The CMRA approach was studied in 10 healthy subjects and compared for both left and right coronary arteries (LCA, RCA) against a reference scan with diaphragmatic navigator gating and tracking. The PET‐CMRA approach was tested in 5 oncology patients with 18 F‐FDG myocardial uptake. PET images were compared against uncorrected and gated PET reconstructions. Results For the healthy subjects, no statistically significant differences in vessel length and sharpness ( P   〉  0.01) were observed between the proposed approach and the reference acquisition with navigator gating and tracking, although data acquisition was significantly shorter. The proposed approach improved CMRA vessel sharpness by 37.9% and 49.1% (LCA, RCA) and vessel length by 48.0% and 36.7% (LCA, RCA) in comparison with no motion correction for all the subjects. Motion‐corrected PET images showed improved sharpness of the myocardium compared to uncorrected reconstructions and reduced noise compared to gated reconstructions. Conclusion Feasibility of a new respiratory motion‐compensated simultaneous cardiac PET‐CMRA acquisition has been demonstrated. Magn Reson Med 79:339–350, 2018. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
    Type of Medium: Online Resource
    ISSN: 0740-3194 , 1522-2594
    URL: Issue
    URL: Article
    DOI: 10.1002/mrm.v79.1
    DOI: 10.1002/mrm.26690
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1493786-4
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  • 2
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    Single Breath-Hold 3-Dimensional Magnetic Resonance Elastography Depicts Liver Fibrosis and Inflammation in Obese Patients
    Ovid Technologies (Wolters Kluwer Health) ; 2023
    In:  Investigative Radiology Vol. 58, No. 6 ( 2023-6), p. 413-419
    Details
    In: Investigative Radiology, Ovid Technologies (Wolters Kluwer Health), Vol. 58, No. 6 ( 2023-6), p. 413-419
    Abstract: Three-dimensional (3D) magnetic resonance elastography (MRE) measures liver fibrosis and inflammation but requires several breath-holds that hamper clinical acceptance. The aim of this study was to evaluate the technical and clinical feasibility of a single breath-hold 3D MRE sequence as a means of measuring liver fibrosis and inflammation in obese patients. Methods From November 2020 to December 2021, subjects were prospectively enrolled and divided into 2 groups. Group 1 included healthy volunteers (n = 10) who served as controls to compare the single breath-hold 3D MRE sequence with a multiple–breath-hold 3D MRE sequence. Group 2 included liver patients (n = 10) who served as participants to evaluate the clinical feasibility of the single breath-hold 3D MRE sequence in measuring liver fibrosis and inflammation. Controls and participants were scanned at 60 Hz mechanical excitation with the single breath-hold 3D MRE sequence to retrieve the magnitude of the complex-valued shear modulus (|G*| [kPa]), the shear wave speed (Cs [m/s] ), and the loss modulus (G" [kPa]). The controls were also scanned with a multiple–breath-hold 3D MRE sequence for comparison, and the participants had histopathology (Ishak scores) for correlation with Cs and G". Results For the 10 controls, 5 were female, and the mean age and body mass index were 33.1 ± 9.5 years and 23.0 ± 2.1 kg/m 2 , respectively. For the 10 participants, 8 were female, and the mean age and body mass index were 45.1 ± 16.5 years and 33.1 ± 4.0 kg/m 2 (obese range), respectively. All participants were suspected of having nonalcoholic fatty liver disease. Bland-Altman analysis of the comparison in controls shows there are nonsignificant differences in |G*|, Cs, and G" below 6.5%, suggesting good consensus between the 2 sequences. For the participants, Cs and G" correlated significantly with Ishak fibrosis and inflammation grades, respectively ( ρ = 0.95, P 〈 0.001, and ρ = 0.84, P = 0.002). Conclusion The single breath-hold 3D MRE sequence may be effective in measuring liver fibrosis and inflammation in obese patients.
    Type of Medium: Online Resource
    ISSN: 1536-0210 , 0020-9996
    URL: Article
    DOI: 10.1097/RLI.0000000000000952
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2023
    detail.hit.zdb_id: 2041543-6
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  • 3
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    Initial experience in staging primary oesophageal/gastro-oesophageal cancer with 18F-FDG PET/MRI
    Springer Science and Business Media LLC ; 2021
    In:  European Journal of Hybrid Imaging Vol. 5, No. 1 ( 2021-12)
    Details
    In: European Journal of Hybrid Imaging, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2021-12)
    Abstract: 18 F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) may improve cancer staging by combining sensitive cancer detection with high-contrast resolution and detail. We compared the diagnostic performance of 18F-FDG PET/MRI to 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging oesophageal/gastro-oesophageal cancer. Following ethical approval and informed consent, participants with newly diagnosed primary oesophageal/gastro-oesophageal cancer were enrolled. Exclusions included prior/concurrent malignancy. Following 324 ± 28 MBq 18F-FDG administration and 60-min uptake, PET/CT was performed, immediately followed by integrated PET/MRI from skull base to mid-thigh. PET/CT was interpreted by two dual-accredited nuclear medicine physicians and PET/MRI by a dual-accredited nuclear medicine physician/radiologist and cancer radiologist in consensus. Per-participant staging was compared with the tumour board consensus staging using the McNemar test, with statistical significance at 5%. Results Out of 26 participants, 22 (20 males; mean ± SD age 68.8 ± 8.7 years) completed 18F-FDG PET/CT and PET/MRI. Compared to the tumour board, the primary tumour was staged concordantly in 55% (12/22) with PET/MRI and 36% (8/22) with PET/CT; the nodal stage was concordant in 45% (10/22) with PET/MRI and 50% (11/22) with PET/CT. There was no statistical difference in PET/CT and PET/MRI staging performance ( p   〉  0.05, for T and N staging). The staging of distant metastases was concordant with the tumour board in 95% (21/22) with both PET/MRI and PET/CT. Of participants with distant metastatic disease, PET/MRI detected additional metastases in 30% (3/10). Conclusion In this preliminary study, compared to 18F-FDG PET/CT, 18F-FDG PET/MRI showed non-significant higher concordance with T-staging, but no difference with N or M-staging. Additional metastases detected by 18F-FDG PET/MRI may be of additive clinical value.
    Type of Medium: Online Resource
    ISSN: 2510-3636
    URL: Article
    DOI: 10.1186/s41824-021-00117-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2886512-1
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  • 4
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    Exploratory radiomic features from integrated 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging are associated with contemporaneous metastases in oesophageal/gastroesophageal cancer
    Springer Science and Business Media LLC ; 2019
    In:  European Journal of Nuclear Medicine and Molecular Imaging Vol. 46, No. 7 ( 2019-7), p. 1478-1484
    Details
    In: European Journal of Nuclear Medicine and Molecular Imaging, Springer Science and Business Media LLC, Vol. 46, No. 7 ( 2019-7), p. 1478-1484
    Type of Medium: Online Resource
    ISSN: 1619-7070 , 1619-7089
    URL: Article
    DOI: 10.1007/s00259-019-04306-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
    detail.hit.zdb_id: 2098375-X
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  • 5
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    Comparison of the diagnostic performance and impact on management of 18F-FDG PET/CT and whole-body MRI in multiple myeloma
    Springer Science and Business Media LLC ; 2021
    In:  European Journal of Nuclear Medicine and Molecular Imaging Vol. 48, No. 8 ( 2021-07), p. 2558-2565
    Details
    In: European Journal of Nuclear Medicine and Molecular Imaging, Springer Science and Business Media LLC, Vol. 48, No. 8 ( 2021-07), p. 2558-2565
    Abstract: Comparative data on the impact of imaging on management is lacking for multiple myeloma. This study compared the diagnostic performance and impact on management of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and whole-body magnetic resonance imaging (WBMRI) in treatment-naive myeloma. Methods Forty-six patients undergoing 18F-FDG PET/CT and WBMRI were reviewed by a nuclear medicine physician and radiologist, respectively, for the presence of myeloma bone disease. Blinded clinical and imaging data were reviewed by two haematologists in consensus and management recorded following clinical data ± 18F-FDG PET/CT or WBMRI. Bone disease was defined using International Myeloma Working Group (IMWG) criteria and a clinical reference standard. Per-patient sensitivity for lesion detection was established. McNemar test compared management based on clinical assessment ± 18F-FDG PET/CT or WBMRI. Results Sensitivity for bone lesions was 69.6% (32/46) for 18F-FDG PET/CT (54.3% (25/46) for PET component alone) and 91.3% (42/46) for WBMRI. 27/46 (58.7%) of cases were concordant. In 19/46 patients (41.3%) WBMRI detected more focal bone lesions than 18F-FDG PET/CT. Based on clinical data alone, 32/46 (69.6%) patients would have been treated. Addition of 18F-FDG PET/CT to clinical data increased this to 40/46 (87.0%) patients ( p = 0.02); and WBMRI to clinical data to 43/46 (93.5%) patients ( p = 0.002). The difference in treatment decisions was not statistically significant between 18F-FDG PET/CT and WBMRI ( p = 0.08). Conclusion Compared to 18F-FDG PET/CT, WBMRI had a higher per patient sensitivity for bone disease. However, treatment decisions were not statistically different and either modality would be appropriate in initial staging, depending on local availability and expertise.
    Type of Medium: Online Resource
    ISSN: 1619-7070 , 1619-7089
    URL: Article
    DOI: 10.1007/s00259-020-05182-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
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  • 6
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    Non‐rigid motion‐compensated 3D whole‐heart T 2 mapping in a hybrid 3T PET‐MR system
    Wiley ; 2024
    In:  Magnetic Resonance in Medicine Vol. 91, No. 5 ( 2024-05), p. 1951-1964
    Details
    In: Magnetic Resonance in Medicine, Wiley, Vol. 91, No. 5 ( 2024-05), p. 1951-1964
    Abstract: Simultaneous PET‐MRI improves inflammatory cardiac disease diagnosis. However, challenges persist in respiratory motion and mis‐registration between free‐breathing 3D PET and 2D breath‐held MR images. We propose a free‐breathing non‐rigid motion‐compensated 3D T 2 ‐mapping sequence enabling whole‐heart myocardial tissue characterization in a hybrid 3T PET‐MR system and provides non‐rigid respiratory motion fields to correct also simultaneously acquired PET data. Methods Free‐breathing 3D whole‐heart T 2 ‐mapping was implemented on a hybrid 3T PET‐MRI system. Three datasets were acquired with different T 2 ‐preparation modules (0, 28, 55 ms) using 3‐fold undersampled variable‐density Cartesian trajectory. Respiratory motion was estimated via virtual 3D image navigators, enabling multi‐contrast non‐rigid motion‐corrected MR reconstruction. T 2 ‐maps were computed using dictionary‐matching. Approach was tested in phantom, 8 healthy subjects, 14 MR only and 2 PET‐MR patients with suspected cardiac disease and compared with spin echo reference (phantom) and clinical 2D T 2 ‐mapping (in‐vivo). Results Phantom results show a high correlation ( R 2 = 0.996) between proposed approach and gold standard 2D T 2 mapping. In‐vivo 3D T 2 ‐mapping average values in healthy subjects (39.0 ± 1.4 ms) and patients (healthy tissue) (39.1 ± 1.4 ms) agree with conventional 2D T 2 ‐mapping (healthy = 38.6 ± 1.2 ms, patients = 40.3 ± 1.7 ms). Bland–Altman analysis reveals bias of 1.8 ms and 95% limits of agreement (LOA) of −2.4‐6 ms for healthy subjects, and bias of 1.3 ms and 95% LOA of −1.9 to 4.6 ms for patients. Conclusion Validated efficient 3D whole‐heart T 2 ‐mapping at hybrid 3T PET‐MRI provides myocardial inflammation characterization and non‐rigid respiratory motion fields for simultaneous PET data correction. Comparable T 2 values were achieved with both 3D and 2D methods. Improved image quality was observed in the PET images after MR‐based motion correction.
    Type of Medium: Online Resource
    ISSN: 0740-3194 , 1522-2594
    URL: Issue
    URL: Article
    DOI: 10.1002/mrm.v91.5
    DOI: 10.1002/mrm.29973
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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