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  • 1
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 10 ( 2022-05-20), p. 6238-
    Abstract: A better understanding of the physical activity (PA) infrastructure in schools, the walkability of neighborhoods close to schools, and the food environments around schools, particularly in rural, socioeconomically challenged areas such as the North-West (NW) of Tasmania, could be important in the wider effort to improve the health of school-age children. Accordingly, this research aimed to assess PA resources, walkability, and food environments in and around schools in three socioeconomically disadvantaged, regional/rural Local Government Areas (LGAs) of Tasmania, Australia. A census of schools (including assessment of the PA infrastructure quality within school grounds), a walkability assessment, and a census of food outlets surrounding schools (through geospatial mapping) were executed. Most of the schools in the study region had access to an oval, basketball/volleyball/netball court, and free-standing exercise equipment. In all instances (i.e., regardless of school type), the quality of the available infrastructure was substantially higher than the number of incivilities observed. Most schools also had good (i.e., within the first four deciles) walkability. Numerous food outlets were within the walking zones of all schools in the study region, with an abundance of food outlets that predominantly sold processed unhealthy food.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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  • 2
    In: Disease Models & Mechanisms, The Company of Biologists
    Abstract: Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes remarkable improvements in cardiometabolic health, including hypertension remission. However, the mechanisms responsible remain undefined and poorly studied. Therefore, we developed and validated the first murine model of VSG that recapitulates the blood pressure lowering effect of VSG using gold-standard radiotelemetry technology. We used this model to investigate several potential mechanisms, including body weight, brain endoplasmic reticulum (ER) stress signaling and brain inflammatory signaling, all critical contributors to obesity-associated hypertension pathogenesis. High fat diet-fed mice underwent sham or VSG surgery and radiotelemeter implantation. Sham mice were fed ad libitum (S-AL) or were food restricted to match their body weight to VSG-operated mice (S-WM) in order to determine the role of body weight in the effect of VSG to lower blood pressure. Blood pressure was measured in freely-moving unstressed mice by radiotelemetry. VSG decreased energy intake, body weight and fat mass. Mean arterial blood pressure (MAP) was reduced in VSG compared with S-WM and S-AL. VSG-induced reductions in MAP were accompanied by a body weight-independent decrease in hypothalamic ER stress, hypothalamic inflammation and sympathetic tone. Gut microbial populations were assessed as a potential contributor, which revealed VSG-induced increases in the relative abundance of Gammaproteobacteria and Enterococcus, and decreases in Adlercreutzia. These results suggest that VSG reduces blood pressure, in part, independently of body weight. VSG-induced reductions in blood pressure may be driven by a decrease in hypothalamic ER stress and inflammatory signaling and shifts in gut microbial populations.
    Type of Medium: Online Resource
    ISSN: 1754-8411 , 1754-8403
    Language: English
    Publisher: The Company of Biologists
    Publication Date: 2017
    detail.hit.zdb_id: 2451104-3
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  • 3
    In: JMIR Research Protocols, JMIR Publications Inc., Vol. 12 ( 2023-2-17), p. e41280-
    Abstract: Social and behavioral determinants of health are increasingly recognized as central to effective person-centered intervention in clinical practice, disease management, and public health. Accordingly, social prescribing (SP) has received increased attention in recent times. The rampant global prevalence of obesity indicates that the customary, reductionistic, and disease-oriented biomedical approach to health service delivery is inadequate/ineffective at arresting the spread and mitigating the damaging consequences of the condition. There is an urgent need to shift the focus from reactive downstream disease-based treatments to more proactive, upstream, preventive action. In essence, this requires more effort to affect the paradigm shift from the traditional “biomedical approach of care” to a “biopsychosocial model” required to arrest the increasing prevalence of obesity. To this end, an SP approach, anchored in systems thinking, could be an effective means of moderating prevalence and consequences of obesity at a community level. Objective The proposed SP intervention has the following three key objectives: (1) build a sustainable program for Circular Head based on SP, peer education, and health screening to minimize the incidence of obesity and related lifestyle diseases; (2) increase service and workforce connectivity and collaboration and initiate the introduction of new services and activities for obesity prevention and community health promotion; and (3) enhance health and well-being and minimize preventable adverse health outcomes of obesity and related lifestyle diseases through enhancement of food literacy and better nutrition, enhancement of physical literacy and habitual personal activity levels, and improvement of mental health, community connectedness, and reduction of social isolation. Methods This paper describes a prospective SP strategy aimed at obesity prevention in Circular Head, a local government area in Northwest (NW) Tasmania. SP is a prominent strategy used in the Critical Age Periods Impacting the Trajectory of Obesogenic Lifestyles Project, which is an initiative based in NW Tasmania focused on assessing obesity prevention capacity. A social prescription model that facilitates the linkage of primary health screening with essential health care, education, and community resources through a dedicated “navigator” will be implemented. Four interlinked work packages will be implemented as part of the initial plan with each either building on existing resources or developing new initiatives. Results A multimethod approach to triangulate insights from quantitative and qualitative research that enables the assessment of impact on individuals, community groups, and the health care system will be implemented within the initial pilot phase of the project. Conclusions Literature is replete with rhetoric advocating complex system approaches to curtail obesity. However, real-life examples of whole-of-systems interventions operationalized in ways that generate relevant evidence or effective policies are rare. The diverse approach for primary prevention of obesity-related lifestyle diseases and strategies for improvement of health and well-being described in this instance will contribute toward closing this evidence gap. International Registered Report Identifier (IRRID) PRR1-10.2196/41280
    Type of Medium: Online Resource
    ISSN: 1929-0748
    Language: English
    Publisher: JMIR Publications Inc.
    Publication Date: 2023
    detail.hit.zdb_id: 2719222-2
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  • 4
    In: Psychoneuroendocrinology, Elsevier BV, Vol. 83 ( 2017-09), p. 30-
    Type of Medium: Online Resource
    ISSN: 0306-4530
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 1500706-6
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  • 5
    Online Resource
    Online Resource
    Elsevier BV ; 2017
    In:  Psychoneuroendocrinology Vol. 83 ( 2017-09), p. 78-
    In: Psychoneuroendocrinology, Elsevier BV, Vol. 83 ( 2017-09), p. 78-
    Type of Medium: Online Resource
    ISSN: 0306-4530
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 1500706-6
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  • 6
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 121, No. 2 ( 2019-01-28), p. 164-171
    Abstract: High Na intake and chronically elevated cortisol levels are independently associated with the development of chronic diseases. In adults, high Na intake is associated with high levels of urinary cortisol. We aimed to determine the association between urinary Na and K and urinary cortisol in a cross-sectional sample of Australian schoolchildren and their mothers. Participants were a sample of Australian children ( n 120) and their mothers ( n 100) recruited through primary schools. We assessed Na, K, free cortisol and cortisol metabolites in one 24 h urine collection. Associations between 24 h urinary electrolytes and 24 h urinary cortisol were assessed using multilevel mixed-effects linear regression models. In children, urinary Na was positively associated with urinary free cortisol ( β =0·31, 95 % CI 0·19, 0·44) and urinary cortisol metabolites ( β =0·006, 95 % CI 0·002, 0·010). Positive associations were also observed between urinary K and urinary free cortisol ( β =0·65, 95 % CI 0·23, 1·07) and urinary cortisol metabolites ( β =0·02, 95 % CI 0·03, 0·031). In mothers, urinary Na was positively associated with urinary free cortisol ( β =0·23, 95 % CI 0·01, 0·50) and urinary cortisol metabolites ( β =0·008, 95 % CI 0·0007, 0·016). Our findings show that daily Na and K intake were positively associated with cortisol production in children and their mothers. Investigation of the mechanisms involved and the potential impact of Na reduction on cortisol levels in these populations is warranted.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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  • 7
    Online Resource
    Online Resource
    MDPI AG ; 2023
    In:  Nutrients Vol. 15, No. 15 ( 2023-07-28), p. 3370-
    In: Nutrients, MDPI AG, Vol. 15, No. 15 ( 2023-07-28), p. 3370-
    Abstract: Despite widespread acknowledgement of the multifarious health benefits of physical activity (PA), including prevention and control of obesity, an overwhelming majority of children and adolescents are not sufficiently active to realise such benefits. Concurrently, young people are significantly impacted by the rapid global rise of sedentarism, and suboptimal dietary patterns during key phases of development. Regrettably, the cumulative effects of unhealthy behaviours during the growing years predisposes young people to the early stages of several chronic conditions, including obesity. Clear and consistent approaches are urgently needed to improve eating and activity behaviours of children and adolescents. Based on existing evidence of “best bets” to prevent and control obesity and its comorbidities, we present a set of non-negotiable strategies as a ‘road map’ to achieving prevention and improving the health of children and adolescents.
    Type of Medium: Online Resource
    ISSN: 2072-6643
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2518386-2
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  • 8
    In: European Journal of Clinical Nutrition, Springer Science and Business Media LLC
    Abstract: Providing all infants with the best start to life is a universal but challenging goal for the global community. Historically, the size and shape of infants, quantified by anthropometry and commencing with birthweight, has been the common yardstick for physical growth and development. Anthropometry has long been considered a proxy for nutritional status during infancy when, under ideal circumstances, changes in size and shape are most rapid. Developed from data collected in the Multicentre Growth Reference Study (MGRS), WHO Child Growth Standards for healthy infants and children have been widely accepted and progressively adopted. In contrast, and somewhat surprisingly, much less is understood about the ‘quality’ of growth as reflected by body composition during infancy. Recent advances in body composition assessment, including the more widespread use of air displacement plethysmography (ADP) across the first months of life, have contributed to a progressive increase in our knowledge and understanding of growth and development. Along with stable isotope approaches, most commonly the deuterium dilution (DD) technique, the criterion measure of total body water (TBW), our ability to quantify lean and fat tissue using a two-compartment model, has been greatly enhanced. However, until now, global reference charts for the body composition of healthy infants have been lacking. This paper details some of the historical challenges associated with the assessment of body composition across the first two years of life, and references the logical next steps in growth assessments, including reference charts.
    Type of Medium: Online Resource
    ISSN: 0954-3007 , 1476-5640
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2004986-9
    SSG: 21
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  • 9
    In: European Journal of Clinical Nutrition, Springer Science and Business Media LLC
    Abstract: Available evidence on infant body composition is limited. This study aimed to investigate factors associated with body composition at 6 and 24 months. Subjects/Methods Multicenter study with data from a 0 to 6-mo cohort (Australia, India and South Africa) and a 3 to 24-mo cohort (Brazil, Pakistan, South Africa, and Sri Lanka). For the 0–6-mo cohort, body composition was assessed by air-displacement plethysmography (ADP) and for the 3–24-month cohort by the deuterium dilution (DD) technique. Fat mass (FM), fat-free mass (FFM), FM index (FMI), and FFM index (FFMI) were calculated. Independent variables comprised the Gini index of the country, maternal and infant characteristics, and breastfeeding pattern at 3 months. For the 3–24-mo cohort, breastfeeding, and minimum dietary diversity (MDD) at 12 months were also included. Crude and adjusted analyses stratified by sex were conducted by multilevel modelling using mixed models. Results At 6 months, every 1 kg increase in birth weight was associated with an increase of 0.716 kg in FFM and 0.582 kg/m 2 in FFMI in girls, whereas in boys, the increase was of 0.277 kg in FFM. At 24 months, compared to those weaned before 12 months, girls still breastfed at 12 months presented a decrease of 0.225 kg in FM, 0.645 kg in FFM and 0.459 kg/m 2 in FFMI, and in boys the decreases were of 0.467 kg in FM, 0.603 kg in FFM and 0.628 kg/m 2 in FFMI. Conclusion Birth weight and breastfeeding are independent predictors of body composition in early life, irrespective of sex.
    Type of Medium: Online Resource
    ISSN: 0954-3007 , 1476-5640
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2004986-9
    SSG: 21
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  • 10
    In: Obesity Facts, S. Karger AG, Vol. 7, No. 6 ( 2014), p. 339-350
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 To determine the effect of adiposity in males aged 50-70 years on cardiovascular responses to acute psychological stress. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Lean (BMI 20-25 kg/m 〈 sup 〉 2 〈 /sup 〉 ) (n = 21) and overweight/obese (BMI 27-35 kg/m 〈 sup 〉 2 〈 /sup 〉 ) (n = 21) men aged 50-70 years were subjected to psychological stress. Systolic blood pressure, diastolic blood pressure, heart rate, total peripheral resistance, and cardiac output were measured by a Finometer during resting (60 min), stress (30 min), and recovery (90 min). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The lean group had a significantly higher SBP stress reactivity when compared to the overweight/obese group (51.5 ± 3.7% vs. 41.0 ± 2.9% (mean ± SEM) ; p 〈 0.05). A significant effect of time was observed for systolic blood pressure, diastolic blood pressure, heart rate, total peripheral resistance, and cardiac output (p 〈 0.0001 for all). There were significant time × body type interactions for systolic blood pressure, diastolic blood pressure, heart rate, total peripheral resistance, and cardiac output (p 〈 0.05 for all). Total peripheral resistance during recovery was higher in the lean compared to the overweight/obese group (p 〈 0.05). In the lean group, systolic and diastolic blood pressure variability remained elevated after stress (p 〈 0.05) but returned to resting levels in the overweight/obese group (p 〉 0.05). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Moderate adiposity in men was associated with reduced systolic blood pressure % reactivity, total peripheral resistance, and blood pressure variability after psychological stress. Overweight/obese men appear to be at no greater risk of unfavorable cardiovascular responses to stress.
    Type of Medium: Online Resource
    ISSN: 1662-4025 , 1662-4033
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2455819-9
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