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  • 1
    Online Resource
    Online Resource
    Genetic architecture of human plasma lipidome and its link to cardiovascular disease
    Springer Science and Business Media LLC ; 2019
    In:  Nature Communications Vol. 10, No. 1 ( 2019-09-24)
    Details
    In: Nature Communications, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2019-09-24)
    Abstract: Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P  〈 5 ×10 −8 ), 10 of which associate with CVD risk including five new loci- COL5A1 , GLTPD2 , SPTLC3 , MBOAT7 and GALNT16 (false discovery rate 〈 0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
    Type of Medium: Online Resource
    ISSN: 2041-1723
    URL: Article
    DOI: 10.1038/s41467-019-11954-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2019
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  • 2
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    Online Resource
    Spreading of Trioza apicalis and development of “ Candidatus Liberibacter solanacearum” infection on carrot in the field conditions
    Wiley ; 2021
    In:  Annals of Applied Biology Vol. 178, No. 1 ( 2021-01), p. 39-50
    Details
    In: Annals of Applied Biology, Wiley, Vol. 178, No. 1 ( 2021-01), p. 39-50
    Abstract: Carrot cultivation in Europe is suffering from infections with “ Candidatus Liberibacter solanacearum” (CLso), a psyllid‐transmitted bacterial pathogen. In this study, field experiments were carried out in Finland to separately measure the effects of psyllid feeding damage and CLso infection on the carrot root growth and to reveal the dynamics of the spreading of CLso within the field. Most of the experiments were carried out during the summers 2016 and 2017, and a follow‐up sampling was performed in 2018. Carrot psyllid ( Trioza apicalis ) flight activity was monitored and carrots were sampled at 25 points within the field. Early in the season a clear spatial correlation was found between the sampling sites showing the psyllid feeding damage, that is, leaf‐curling, up to the range of 40–60 m, indicating aggregation behaviour of the psyllids. No CLso infections were detected in the first sampling, which was performed before the psyllid flight peak in both years. Later, a positive correlation between the psyllid feeding damage and the CLso titre was observed. An increase in the CLso titre occurred approximately a month after the psyllid flight peak, and this increase correlated with the accumulating effective temperature sum. In 2016, both the psyllid feeding damage and CLso infection had a significant effect on the carrot root weight. The effect of CLso titre on root weight was nonlinear, that is, it intensified rapidly at the highest bacterial titres. During the colder summer of 2017 the CLso titres did not reach high enough levels in the plants to cause substantial visible symptoms and root growth reduction. Thus, it seems that in the Nordic conditions the effect of CLso infection on carrot yield is strongly dependent on the weather conditions during the growing season.
    Type of Medium: Online Resource
    ISSN: 0003-4746 , 1744-7348
    URL: Issue
    URL: Article
    DOI: 10.1111/aab.v178.1
    DOI: 10.1111/aab.12644
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2025001-0
    SSG: 12
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  • 3
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    Spontaneous Peripelvic Extravasation of Urine as a Cause of Acute Abdomen
    Informa UK Limited ; 1993
    In:  Scandinavian Journal of Urology and Nephrology Vol. 27, No. 3 ( 1993-09-01), p. 333-336
    Details
    In: Scandinavian Journal of Urology and Nephrology, Informa UK Limited, Vol. 27, No. 3 ( 1993-09-01), p. 333-336
    Type of Medium: Online Resource
    ISSN: 0036-5599 , 1651-2065
    URL: Article
    DOI: 10.3109/00365599309180443
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 1993
    detail.hit.zdb_id: 2702519-6
    detail.hit.zdb_id: 1492497-3
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  • 4
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    Online Resource
    Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography–electrospray ionization mass spectrometry
    Elsevier BV ; 2009
    In:  Journal of Chromatography B Vol. 877, No. 27 ( 2009-10), p. 2967-2975
    Details
    In: Journal of Chromatography B, Elsevier BV, Vol. 877, No. 27 ( 2009-10), p. 2967-2975
    Type of Medium: Online Resource
    ISSN: 1570-0232
    URL: Article
    DOI: 10.1016/j.jchromb.2009.07.010
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2009
    detail.hit.zdb_id: 1491259-4
    SSG: 11
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  • 5
    Online Resource
    Online Resource
    Effect of space allowance and earthen flooring on behaviour of farmed blue foxes
    Springer Science and Business Media LLC ; 2001
    In:  Acta ethologica Vol. 4, No. 1 ( 2001-8-1), p. 11-21
    Details
    In: Acta ethologica, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2001-8-1), p. 11-21
    Type of Medium: Online Resource
    ISSN: 0873-9749 , 1437-9546
    URL: Article
    DOI: 10.1007/s102110100046
    Language: Unknown
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2001
    detail.hit.zdb_id: 1499105-6
    SSG: 12
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  • 6
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    Online Resource
    On the quality of RS41 radiosonde descent data
    Copernicus GmbH ; 2022
    In:  Atmospheric Measurement Techniques Vol. 15, No. 1 ( 2022-01-11), p. 165-183
    Details
    In: Atmospheric Measurement Techniques, Copernicus GmbH, Vol. 15, No. 1 ( 2022-01-11), p. 165-183
    Abstract: Abstract. Radiosonde descent profiles have been available from tens of stations for several years now – mainly from Vaisala RS41 radiosondes. They have been compared with the ascent profiles, with ECMWF short-range forecasts and with co-located radio occultation retrievals. Over this time, our understanding of the data has grown, and the comparison has also shed some light on radiosonde ascent data. The fall rate is very variable and is an important factor, with high fall rates being associated with temperature biases, especially at higher altitudes. Ascent winds are affected by pendulum motion; on average, descent winds are less affected by pendulum motion and are smoother. It is plausible that the true wind variability in the vertical lies between that shown by ascent and descent profiles. This discrepancy indicates the need for reference wind measurements. With current processing, the best results are for radiosondes with parachutes and pressure sensors. Some of the wind, temperature and humidity data are now assimilated in the ECMWF forecast system.
    Type of Medium: Online Resource
    ISSN: 1867-8548
    URL: Article
    URL: Article
    DOI: 10.5194/amt-15-165-2022
    DOI: 10.5194/amt-15-165-2022-supplement
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2022
    detail.hit.zdb_id: 2505596-3
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  • 7
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    Online Resource
    Strong day-to-day variability of the Asian Tropopause Aerosol Layer (ATAL) in August 2016 at the Himalayan foothills
    Copernicus GmbH ; 2020
    In:  Atmospheric Chemistry and Physics Vol. 20, No. 22 ( 2020-11-24), p. 14273-14302
    Details
    In: Atmospheric Chemistry and Physics, Copernicus GmbH, Vol. 20, No. 22 ( 2020-11-24), p. 14273-14302
    Abstract: Abstract. The South Asian summer monsoon is associated with a large-scale anticyclonic circulation in the upper troposphere and lower stratosphere (UTLS), which confines the air mass inside. During boreal summer, the confinement of this air mass leads to an accumulation of aerosol between about 13 and 18 km (360 and 440 K potential temperature); this accumulation of aerosol constitutes the Asian Tropopause Aerosol Layer (ATAL). We present balloon-borne aerosol backscatter measurements of the ATAL performed by the Compact Optical Backscatter Aerosol Detector (COBALD) instrument in Nainital in northern India in August 2016, and compare these with COBALD measurements in the post-monsoon time in November 2016. The measurements demonstrate a strong variability of the ATAL's altitude, vertical extent, aerosol backscatter intensity and cirrus cloud occurrence frequency. Such a variability cannot be deduced from climatological means of the ATAL as they are derived from satellite measurements. To explain this observed variability we performed a Lagrangian back-trajectory analysis using the Chemical Lagrangian Model of the Stratosphere (CLaMS). We identify the transport pathways as well as the source regions of air parcels contributing to the ATAL over Nainital in August 2016. Our analysis reveals a variety of factors contributing to the observed day-to-day variability of the ATAL: continental convection, tropical cyclones (maritime convection), dynamics of the anticyclone and stratospheric intrusions. Thus, the air in the ATAL is a mixture of air masses coming from different atmospheric altitude layers. In addition, contributions from the model boundary layer originate in different geographic source regions. The location of the strongest updraft along the backward trajectories reveals a cluster of strong upward transport at the southern edge of the Himalayan foothills. From the top of the convective outflow level (about 13 km; 360 K) the air parcels ascend slowly to ATAL altitudes within a large-scale upward spiral driven by the diabatic heating in the anticyclonic flow of the South Asian summer monsoon at UTLS altitudes. Cases with a strong ATAL typically show boundary layer contributions from the Tibetan Plateau, the foothills of the Himalayas and other continental regions below the Asian monsoon. Weaker ATAL cases show higher contributions from the maritime boundary layer, often related to tropical cyclones, indicating a mixing of clean maritime and polluted continental air. On the one hand increasing anthropogenic emissions in the future are expected due to the strong growth of Asian economies; on the other hand the implementation of new emission control measures (in particular in China) has reduced the anthropogenic emissions of some pollutants contributing to the ATAL substantially. It needs to be monitored in the future whether the thickness and intensity of the ATAL will further increase, which will likely impact the surface climate.
    Type of Medium: Online Resource
    ISSN: 1680-7324
    URL: Article
    DOI: 10.5194/acp-20-14273-2020
    Language: English
    Publisher: Copernicus GmbH
    Publication Date: 2020
    detail.hit.zdb_id: 2092549-9
    detail.hit.zdb_id: 2069847-1
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  • 8
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    Finnish Farmers Feel They Have Succeeded in Adopting Cover Crops but Need Down-to-Earth Support from Research
    MDPI AG ; 2023
    In:  Agronomy Vol. 13, No. 9 ( 2023-09-05), p. 2326-
    Details
    In: Agronomy, MDPI AG, Vol. 13, No. 9 ( 2023-09-05), p. 2326-
    Abstract: In Finland, there is an ongoing adoption and learning process considering the cultivation of cover crops (CCs). The primary aim is to claim the benefits of CCs for agricultural production and ecosystems, which are both appreciated by Finnish farmers. A farmer survey with 1130 respondents was carried out to build an up-to-date understanding of how farmers have succeeded with CCs and whether they intend to continue with the use of CCs and to collect farmers’ views on knowledge gaps that should be filled by research or better knowledge sharing. The studied groups were farmers who had selected CCs as a registered measure in 2020 to receive agricultural payments. Data came from the Finnish Food Authority. Organic farmers were slightly more positive: they have had longer experience with CCs, but organic production is also more dependent on the ecosystem services provided by CCs. A high share of respondents agreed that their experiences with CCs have improved over time and were confident that CCs had become a permanent element of their production systems. Most of the farmers also agreed that the area under CCs would expand significantly in Finland and considered the cultivation of CCs as an effective measure to improve soil conditions. They often considered that challenges in adopting CCs were exaggerated and disagreed that bad experiences prevented them from expanding or continuing the use of CCs. The agricultural payment available for Finnish farmers to support the cultivation of CCs is quite reasonable (EUR 97 + EUR 50 per hectare) to compensate for any economic risks of CCs. Free word answers from the farmers highlighted research needs (in descending order) in the following areas: crop protection, sowing practices, the use of diverse CCs and their mixtures, and impacts on yield and profitability. Many of these are universal, i.e., have been reported elsewhere. Younger farmers (≤50 years) highlighted profitability, which is, in many European countries, a key barrier to the deployment of CCs. Farmers from the east and north regions, where the growing season is short, highlighted alternative CC choices as a knowledge gap.
    Type of Medium: Online Resource
    ISSN: 2073-4395
    URL: Article
    DOI: 10.3390/agronomy13092326
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2607043-1
    SSG: 23
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  • 9
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    Trim37 -deficient mice recapitulate several features of the multi-organ disorder Mulibrey nanism
    The Company of Biologists ; 2016
    In:  Biology Open Vol. 5, No. 5 ( 2016-05-15), p. 584-595
    Details
    In: Biology Open, The Company of Biologists, Vol. 5, No. 5 ( 2016-05-15), p. 584-595
    Abstract: Mulibrey nanism (MUL) is a rare autosomal recessive multi-organ disorder characterized by severe prenatal-onset growth failure, infertility, cardiopathy, risk for tumors, fatty liver, and type 2 diabetes. MUL is caused by loss-of-function mutations in TRIM37, which encodes an E3 ubiquitin ligase belonging to the tripartite motif (TRIM) protein family and having both peroxisomal and nuclear localization. We describe a congenic Trim37 knock-out mouse (Trim37−/−) model for MUL. Trim37−/− mice were viable and had normal weight development until approximately 12 months of age, after which they started to manifest increasing problems in wellbeing and weight loss. Assessment of skeletal parameters with computer tomography revealed significantly smaller skull size, but no difference in the lengths of long bones in Trim37−/− mice as compared with wild-type. Both male and female Trim37−/− mice were infertile, the gonads showing germ cell aplasia, hilus and Leydig cell hyperplasia and accumulation of lipids in and around Leydig cells. Male Trim37−/− mice had elevated levels of follicle-stimulating and luteinizing hormones, but maintained normal levels of testosterone. Six-month-old Trim37−/− mice had elevated fasting blood glucose and low fasting serum insulin levels. At 1.5 years Trim37−/− mice showed non-compaction cardiomyopathy, hepatomegaly, fatty liver and various tumors. The amount and morphology of liver peroxisomes seemed normal in Trim37−/− mice. The most consistently seen phenotypes in Trim37−/− mice were infertility and the associated hormonal findings, whereas there was more variability in the other phenotypes observed. Trim37−/− mice recapitulate several features of the human MUL disease and thus provide a good model to study disease pathogenesis related to TRIM37 deficiency, including infertility, non-alcoholic fatty liver disease, cardiomyopathy and tumorigenesis.
    Type of Medium: Online Resource
    ISSN: 2046-6390
    URL: Article
    DOI: 10.1242/bio.016246
    Language: English
    Publisher: The Company of Biologists
    Publication Date: 2016
    detail.hit.zdb_id: 2632264-X
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  • 10
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    Herne lakoutuu harvoin, tukikaura varmistaa loput
    Suomen Maataloustieteellisen Seuran Tiedote ; 2012
    In:  Suomen Maataloustieteellisen Seuran Tiedote , No. 28 ( 2012-01-31), p. 1-6
    Details
    In: Suomen Maataloustieteellisen Seuran Tiedote, Suomen Maataloustieteellisen Seuran Tiedote, , No. 28 ( 2012-01-31), p. 1-6
    Abstract: Herneen viljelyvarmuus on kehittynyt viimeisen puolen vuosisadan aikana kenties enemmän kuin minkään muun peltokasvilajimme. Aikoinaan peltoherne kasvoi metrikaupalla maata pitkin ja kukki pitkälle syksyyn. Sitten löydettiin mutantti hernemuoto, jossa lehdykät olivat muuttuneet kärhiksi. Jalostus alkoi kohdistua lehdyköiden osittaiseen korvaamiseen kärhillä ja korvakkeiden koon säätelyyn. Myös varren tyven vahvistaminen on ollut tärkeä jalostuskohde. Ensimmäinen suomalainen puolilehdetön lajike, Hankkijan Tammi, laskettiin kauppaan 1984. Vasta sen jälkeen tulleiden lajikkeiden myötä laonkesto parani. Nykyiset puolilehdettömät hernelajikkeet pysyvät pääsääntöisesti pystyssä. Liian multavassa maassa tai kasvun kannalta erityisen edullisissa kosteusoloissa herne kuitenkin voi lakoutua etenkin, jos palon täyttymisen aikaan tulee runsaita sateita. Silloin tukikasvi voi auttaa herneen pystyssä pysymistä. Peltolohkovalinnan, tukikasvin käytön ja rikkakasvien torjunnan lisäksi pystyssä pysymistä voi varmentaa huolellisen kylvön ja riittävän siemenmäärän avulla. Riittävässä tiheydessä herneet pitivät toisiaan kärhien avulla paremmin pystyssä. Jokioisissa verrattiin eri kevätviljoja herneen tukikasveina kolmena kesänä. Tukiviljoiksi valittiin lajikkeita, joiden laonkesto on hyvä ja kasvuaika mahdollisimman lähellä Hulda –herneen kasvuaikaa. Tukiviljojen kylvötiheys määräytyi sen perusteella, että aiemmissa tutkimuksissa sopivaksi tukikauran osuudeksi siemenseoksen kokonaispainosta oli todettu 7,5 prosenttia. Herne ei mennyt lainkaan lakoon vuonna 2009 rehevästä kasvustaan huolimatta, eikä myöskään seuraavana, hieman heikompikasvuisena kesänä. Vuonna 2011 lakoutuminen pyrittiin varmistamaan sijoittamalla koe alueelle, joka viljelykokemusten mukaan kasvoi yleensä rehevästi eikä kärsinyt helposti kuivuudesta. Multavuudeltaan tämä hiuesaveksi määritelty maa tosin oli vastaavanlaista kuin ensimmäisen kesän koealue eli luokassa ”multava”, humuspitoisuuden ollessa hieman yli 5 %. Hyvän kasvun ja lakoutumisen varmistamiseksi varauduttiin sadetukseenkin. Sateet kesän mittaan kuitenkin auttoivat rehevään kasvuun. Runsaat sateet palkojen täyttymisen aikaan varmistivat lopputuloksen: herne meni kolmen vuoden odotuksen jälkeen lakoon. Kaura tukikasvina esti herneen lakoutumista varsin hyvin. Tavallista korkeammaksi kasvanut herne vei tehon kääpiökauralta; se esti herneen lakoa vain, kun herne ei ollut aivan pisimmillään. Ohra piti hernettä pystyssä pidempään kuin kääpiökaura, vaikka lopulta lako niiden kesken oli samaa luokkaa. Kevätvehnä auttoi hyvin heikosti pystyssä pysymistä. MTT:n pitkäaikaisten herneaineistojen tarkastelu sääaineistojen rinnalla vahvisti oletuksia herneen lakoa aiheuttavista riskitekijöistä. Huomattava lakoriskin lisääntyminen savia kevyemmissä maissa kuvannee osittain lakoherkkyyttä herneen kannalta liian multavissa maissa. Sateet alkukesällä auttavat herneen hyvään kasvuun ja antavat edellytykset runsaaseen palkojen muodostukseen, mikä osaltaan lisää myös lakoutumisen edellytyksiä. Palkojen täyttymisvaiheen sateisuuden lakoa lisäävä riski sai tilastollista vahvistusta. Kesän 2011 tukikasvikoe osoitti, että erittäin lakoalttiissa oloissa kaura on viljoistamme paras herneen lakoutumisen estäjä.
    Type of Medium: Online Resource
    ISSN: 0358-5220
    URL: Article
    DOI: 10.33354/smst.75486
    Language: Unknown
    Publisher: Suomen Maataloustieteellisen Seuran Tiedote
    Publication Date: 2012
    detail.hit.zdb_id: 3111160-9
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