In:
Radiation Oncology, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2013-12)
Abstract:
The purpose of this study was to determine the α/β ratio for normal liver with hepatitis by analyzing the toxicity data from patients with unresectable hepatocellular carcinoma treated with helical tomotherapy. Methods Between March 2006 and February 2012, 98 patients were eligible for this study. 66 patients received 45–50 Gy in 4.5-5 Gy fractions (Group A) and 32 patients received 36–60 Gy in 2.5-3 Gy fractions (Group B). Radiation-induced hepatic toxicity was defined as an increase of at least 2 points in the Child-Pugh score within 4 months of completing helical tomotherapy. We attempted to find the statistically significant parameters in the 2 groups using α/β ratios of 2, 4, 6, 8, or 10, and compared the estimated probability curves of each significant parameter. We hypothesized that the α/β ratio associated with the best matches for the curves between the 2 groups would be equivalent to the α/β ratio for the normal liver. Results When using an α/β ratio of 2 or 4, different parameters were found to be statistically significant in a multivariate analysis (Group A: V BED30 for α/β ratio = 2 and V BED25 for α/β ratio = 4, Group B: V BED25 for α/β ratio = 2 and V BED20 for α/β ratio = 4). When using an α/β ratio of 6, 8, or 10, V BED20 was found to be a statistically significant parameter in both groups. Comparison of the estimated probability curve of each significant parameter between the groups revealed that an α/β ratio of 8 resulted in the best matches. Conclusions We suggest that the α/β ratio of the normal liver with hepatitis is 8. We hope that previously reported parameters and their values can be effectively used in different fractionation schemes by calculating the biologically effective dose using an α/β ratio of 8.
Type of Medium:
Online Resource
ISSN:
1748-717X
DOI:
10.1186/1748-717X-8-61
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2013
detail.hit.zdb_id:
2224965-5
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