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  • 1
    Online Resource
    Online Resource
    Clinical Relevance of Haematologic Parameters in Predicting the Malignant Potential of Suspicious Renal Masses
    Walter de Gruyter GmbH ; 2015
    In:  Acta Chirurgica Latviensis Vol. 15, No. 1 ( 2015-4-1), p. 12-17
    Details
    In: Acta Chirurgica Latviensis, Walter de Gruyter GmbH, Vol. 15, No. 1 ( 2015-4-1), p. 12-17
    Abstract: Introduction. The expanded use of imaging technology has led to improvements in the early diagnosis of kidney cancer. However, providing correct diagnoses regarding the malignant potential of small renal lesions remains problematic for clinicians. In addition to imaging, pre-operative investigations usually include a complete blood count and biochemistry tests. Aim of the study. To evaluate whether the pre-operative blood cell count, cell ratios, C-reactive protein (CRP) levels, and erythrocyte sedimentation rate (ESR) can be helpful in predicting the malignancy of visually suspicious renal masses prior to surgery. Material and methods. Data on pre-operative blood tests were retrospectively collected from 84 cases of stage I renal cell carcinoma (RCC) and 55 benign lesions from patients hospitalized after a radiological finding of renal cancer and following nephrectomy. The predictive ability of various blood tests for malignant potential was analysed using the following statistical methods: the Mann- Whitney U test, receiver operating characteristic (ROC) curves and binary logistic regression. Results. The mean CRP levels, monocyte (Mo) counts, platelet (PLT) counts and monocyte/lymphocyte ratios (MLRs) varied significantly between the patients with stage I RCC and patients that had benign renal lesions with a small effect size. Among these tests, the highest AUCs were displayed by CRP [0.704, 95% confidence interval: 0.567 - 0.807] and MLR [0.736, 0.612 - 0.861] . Based on the ROC curves, optimal cut-off values of 0.26 for MLR and 1.75 mg/L for CRO were selected. A binary logistic regression was used to determine if the combination of CRP and MLR could be used to predict whether patients with renal lesions had cancer resulting in increase of area under the curve (AUC) to 0.798 [0.690 -0.905]. Conclusions. In cases of diagnostic difficulties observing small renal lesions radiologically, the combination of elevated CRP levels and MLRs above 0.26 may help to confirm the presence of renal cancer.
    Type of Medium: Online Resource
    ISSN: 1407-981X
    URL: Article
    DOI: 10.1515/chilat-2016-0003
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2015
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  • 2
    Online Resource
    Online Resource
    CD63 and Dna Mismatch Repair Protein Expression in Prostate Cancer
    Walter de Gruyter GmbH ; 2021
    In:  Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. Vol. 75, No. 3 ( 2021-06-01), p. 180-185
    Details
    In: Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences., Walter de Gruyter GmbH, Vol. 75, No. 3 ( 2021-06-01), p. 180-185
    Abstract: Protein expression levels in immunohistochemistry and molecular biomarkers have been reported for their ability to predict recurrence, progression, development of metastases, and patient survival. The molecular features in low- and high-grade prostate cancer can differ and influence treatment decision and prognosis. The objective of the current study was to compare the expression of exosomal biomarkers CD63 and mismatch repair proteins (MSH2, MSH6, MLH1, and PMS2) by immunohistochemistry (IHC) in tissue of patients with prostate cancer and benign hyperplasia. Altogether, 62 patients with prostate acinar adenocarcinoma and 20 patients with prostate benign hyperplasia were enrolled in this retrospective study. CD63, MSH2, MSH6, MLH1, and PMS2 expression was analysed by immunohistochemistry. The obtained results showed that CD63 expression was significantly higher in patients with Grade III–V prostate cancer compared to Grade I–II, respectively; 2.23 (1–3) vs 0.92 (0–2) score, p = 0.001. In addition, a significant positive correlation between CD63 expression and grade groups was revealed (Rho = +0.54; p 〈 0.0001). Furthermore, progression-free survival was significantly higher in patients with low CD63 expression, compared to high CD63 expression (p = 0.0007). MMR expression was absent in 14 patients (four patients with Grade I–II cancer and 10 patients with Grade III–cancer). MMR was present in all cases of benign prostate hyperplasia (mild to moderate staining). The conclusion was that high grade prostate cancer (Grade groups III–V) was characterised by increased CD63 expression, which correlated with progression-free survival.
    Type of Medium: Online Resource
    ISSN: 2255-890X
    URL: Article
    DOI: 10.2478/prolas-2021-0027
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    Clinicopathological Significance of Exosomal Proteins CD9 and CD63 and DNA Mismatch Repair Proteins in Prostate Adenocarcinoma and Benign Hyperplasia
    MDPI AG ; 2022
    In:  Diagnostics Vol. 12, No. 2 ( 2022-01-24), p. 287-
    Details
    In: Diagnostics, MDPI AG, Vol. 12, No. 2 ( 2022-01-24), p. 287-
    Abstract: Introduction. Recently, it has been shown that exosomal biomarkers and DNA mismatch repair proteins (MMR) could play an important role in cancer risk stratification and prognosis assessment. The gold standard for prostate carcinoma (PCa) diagnosis is biopsy and histopathological examination. Thus, the complex evaluation of exosomal and MMR proteins could be beneficial for prostate cancer risk stratification and diagnostics. The aim of the current study was to evaluate and compare the expression of exosomal proteins CD9 and CD63 and MMR proteins in the tissue of patients with prostate benign hyperplasia (BPH) and PCa. Methods. The study was retrospective. Altogether, 92 patients with PCa and 20 patients with BPH (control group) were enrolled in the study. Exosomal and MMR protein expression was analyzed by immunohistochemistry (IHC). The follow-up for each PCa patient in our study lasted till disease progression and/or a maximum of 5 years. Results. Low-grade PCa was observed in 56 patients and high-grade PCa in 36 patients. CD63 expression was significantly higher in patients with high-grade PCa compared to those with low-grade PCa. CD9 expression was significantly downregulated in PCa patients compared to the control group. MMR protein expression deficiency was observed in 10 PCa patients. MMR proteins were maintained in all cases of BPH. The study found a negative correlation between MMR protein loss and PCa ISUP grade groups. Progression-free survival (PFS) in patients with MMR deficiency was significantly shorter than in patients with maintained MMR expression. Conclusions. CD9 protein expression was downregulated in PCa, compared to BPH, while CD63 protein expression was upregulated in high-grade PCa but downregulated in low-grade PCa. CD63 protein upregulation, CD9 downregulation, and loss of MMR protein characterized the shorter PFS of high-grade PCa patients. CD9, CD63, and MMR could be the routine immunohistochemical biomarkers for the diagnosis and risk stratification of PCa.
    Type of Medium: Online Resource
    ISSN: 2075-4418
    URL: Article
    DOI: 10.3390/diagnostics12020287
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662336-5
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