In:
Open Forum Infectious Diseases, Oxford University Press (OUP)
Abstract:
Side effects to SARS-CoV-2 vaccines are a key concern contributing to vaccine hesitancy, but more individuals may be encouraged if they were known to lead to a stronger immune response. Methods Adult participants were included from the Danish National Cohort Study of Effectiveness and Safety of SARS-CoV-2 Vaccines (ENFORCE), who completed a questionnaire to assess systemic reactions following SARS-CoV-2 vaccination (BTN162b2, mRNA-1273, ChAdOx1) and had SARS-CoV-2 spike IgG levels measured at baseline and post-vaccine. A symptom score was developed to measure severity of systemic adverse reactions (+1 for each moderate, +2 for each severe). Post-vaccination SARS-CoV-2 spike IgG levels were compared between participants with different scores using multivariable linear regression. Results A total of 6528 participants were included (56.3% females, median age 64 years [IQR 54-75]). After first vaccination, no association was found between symptom score and post-vaccine dose spike IgG level (p-value=0.575). Following second vaccination, significantly higher spike IgG levels were observed according to higher symptom score (p & lt;0.001); adjusted geometric mean ratios (95% CIs) were 1.16 (1.04-1.30), 1.24 (1.09-1.41), 1.25 (1.06-1.46), and 1.21 (1.08-1.35), for scores of 2, 3, 4, ≥5, respectively, compared to a score of 0. After adjustment for pre-vaccine dose spike IgG, this association was attenuated. Conclusions An association was found between more severe adverse reactions and stronger antibody response after the second vaccination but not the first, likely attributed to higher levels of pre-existing immunity gained from response to first vaccination. Regardless of side effects, most people experienced an effective immune response following vaccination.
Type of Medium:
Online Resource
ISSN:
2328-8957
DOI:
10.1093/ofid/ofad248
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2023
detail.hit.zdb_id:
2757767-3
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