In:
Journal of Applied Toxicology, Wiley, Vol. 34, No. 12 ( 2014-12), p. 1389-1399
Abstract:
Glycidol has shown effects on hippocampal neurogenesis after developmental exposure to rats. In this study, pregnant rats were given drinking water containing glycidol, and offspring were subjected to region‐specific microarray analysis in four different brain areas. Gene expression alterations suggesting effects on neuronal plasticity were observed in all brain areas at 1000 ppm. Among them, genes in the hippocampal dentate gyrus were downregulated at ≥ 300 ppm, suggesting that neurogenesis might be the sensitive target of this type of toxicity.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1475015-6
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