In:
Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 28, No. 39 ( 2021-12-22), p. 8068-8082
Abstract:
Over the past several decades, plant-derived products (phytochemicals) have
been suggested to possess immense therapeutic potential. Am ong these phytochemicals,
different flavonoids have been reported for their potent anticancer activity. To exhibit their anticancer potential, these flavonoids modulate different signaling pathways.
Among these pathways, the mammalian target of rapamycin (mTOR) and associated phosphatidyl-inositol 3-kinase (PI3K)/protein kinase B (Akt) signaling cascade have
been reported as a pivotal modulator of cell survival, proliferation, and death/apoptosis. Hence, targeting this cascade could be an ideal strategy to alleviate apoptosis and inhibit
proliferation in different forms of cancer. The targeting of PI3K/Akt/mTOR by flavonoids have been well documented in the scientific literature. In the current study,
we have studied the anticancer potential of various flavonoids, especially flavones, flavonols, and isoflavones that include apigenin, luteolin, baicalein, tangeretin, epigallocatechin-
3-gallate, genistein, and daidzein especially dealing with mTOR targeting.
Type of Medium:
Online Resource
ISSN:
0929-8673
DOI:
10.2174/0929867327666201109122025
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
Permalink