In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 10 ( 2007-10), p. 2266-2272
Abstract:
The expression of short hairpin RNA (shRNA) in hematopoietic stem cells by a lentiviral vector resulted in inhibition of targeted protein in platelets, suggesting that shRNA expression driven by the U6 promoter is preserved during megakaryopoiesis. Talin silencing by this method caused significant reduction of inside-out αIIbβ3 signaling in platelets.
Type of Medium:
Online Resource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/ATVBAHA.107.149872
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2007
detail.hit.zdb_id:
1494427-3
Permalink