In:
Magnetic Resonance in Chemistry, Wiley, Vol. 45, No. 2 ( 2007-02), p. 167-170
Abstract:
The submicron liquid droplets constituting the particulate matter of mainstream tobacco smoke (PM MTS ) are viscous and of a composition that is complex and poorly understood. PM MTS is often ∼80% w/w ‘tar’ where ‘tar’ = total PM MTS − (nicotine + water). Many of the chemical agents in MTS responsible for smoking‐related cancers are found at least partially in the PM MTS portion of MTS. The properties of PM MTS vary with brand and with puffing patterns. The chemical forms and total levels of nicotine, the identities/levels of other compositionally dominant compounds, and the identities/levels of carcinogens are of interest. Most studies of the composition of PM MTS have involved extraction then chromatography. Such methods allow the determination of low‐level constituents, but alter the samples such that direct information regarding chemical conditions within the PM MTS cannot be obtained. Here, we utilize nuclear magnetic resonance spectroscopy (NMR) to examine native PM MTS in conventional cigarettes, including measurements of the brand‐dependent fraction of PM MTS nicotine that is in the free‐base form (increasing this fraction in inhaled tobacco smoke affects the rates of the processes governing nicotine deposition in the respiratory tract, and so has implications for smoking behavior and addiction). We also demonstrate the use of NMR for characterizing the composition of PM MTS (including the levels of selected cigarette additives) when the cosolvent DMSO‐d 6 is added to improve spectral resolution. The native and solvent‐assisted results open the door to a range of future studies. Copyright © 2006 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0749-1581
,
1097-458X
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
1475029-6
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