In:
International Journal of Sports Physiology and Performance, Human Kinetics, Vol. 10, No. 8 ( 2015-11), p. 1041-1047
Abstract:
To investigate changes after a mountain ultramarathon (MUM) in the serum concentration of fast (FM) and slow (SM) myosin isoforms, which are fiber-type-specific sarcomere proteins. The changes were compared against creatine kinase (CK), a widely used fiber-sarcolemma-damage biomarker, and cardiac troponin I (cTnI), a widely used cardiac biomarker. Methods: Observational comparison of response in a single group of 8 endurance-trained amateur athletes. Time-related changes in serum levels of CK, cTnI, SM, and FM from competitors were analyzed before, 1 h after the MUM, and 24 and 48 h after the start of the MUM by 1-way ANOVA for repeated measures or Friedman and Wilcoxon tests. Pearson correlation coefficient was employed to examine associations between variables. Results: While SM was significantly ( P = .009) increased in serum 24 h after the beginning of the MUM, FM and cTnI did not change significantly. Serum CK activity peak was observed 1 h after the MUM ( P = .002). Moreover, serum peaks of CK and SM were highly correlated ( r = .884, P = .004). Conclusions: Since there is evidence of muscle damage after prolonged mountain running, the increase in SM serum concentration after a MUM could be indirect evidence of slow- (type I) fiber-specific sarcomere disruptions.
Type of Medium:
Online Resource
ISSN:
1555-0265
,
1555-0273
DOI:
10.1123/ijspp.2014-0267
Language:
Unknown
Publisher:
Human Kinetics
Publication Date:
2015
SSG:
31
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