In:
Cancer Science, Wiley, Vol. 106, No. 12 ( 2015-12), p. 1750-1760
Abstract:
The host immune system plays a significant role in tumor control, although most cancers escape immune surveillance through a variety of mechanisms. The aim of the present study was to evaluate the clinicopathological significance of a novel co‐inhibitory receptor, B and T lymphocyte attenuator ( BTLA ), the anergy cell marker Casitas–B‐lineage lymphoma protein‐b (Cbl‐b), and clinical implications of tumor‐infiltrating immune cells in gallbladder cancer ( GBC ) tissues. We investigated 211 cases of GBC , 21 cases of chronic cholecystitis ( CC ), and 11 cases of xanthogranulomatous cholecystitis ( XGC ) using immunohistochemistry to detect tissue‐infiltrating immune cells and their expression of BTLA and Cbl‐b, and carried out correlation and survival analyses. The density of infiltrating T cells was significantly higher in CC and XGC than in GBC . The density ratio of BTLA + cells to CD 8 + T cells ( BTLA / CD 8) and that of Cbl‐b + cells to CD 8 + T cells (Cbl‐b/ CD 8) were significantly higher in GBC than in CC and XGC . The FOXP 3/ CD 4, BTLA / CD 8, and Cbl‐b/ CD 8 ratios were significantly correlated with each other, and also with malignant phenotypes. Survival analyses revealed that a lower density of tumor‐infiltrating CD 8 + cells, and higher Foxp3/ CD 4, BTLA / CD 8, and Cbl‐b/ CD 8 ratios were significantly associated with shorter overall survival and disease‐free survival in GBC patients. Multivariate analyses showed that M factor, perineural invasion, BTLA / CD 8, and Cbl‐b/ CD 8 were closely associated with shorter overall survival. These findings suggest that higher ratios of BTLA / CD 8 and Cbl‐b/ CD 8 are independent indicators of unfavorable outcome in GBC patients, and that upregulation of BTLA in cancer tissues is involved in inhibition of antitumor immunity.
Type of Medium:
Online Resource
ISSN:
1347-9032
,
1349-7006
DOI:
10.1111/cas.2015.106.issue-12
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2115647-5
detail.hit.zdb_id:
2111204-6
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