In:
Journal of Endotoxin Research, SAGE Publications, Vol. 10, No. 4 ( 2004-08), p. 241-246
Abstract:
The multifaceted response of the fruitfly Drosophila melanogaster to infection by a wide range of microbes is complex and remarkably efficient. Its most prominent aspect is the immune-inducible expression of a set of potent antimicrobial peptides. Genetic analysis of the regulation of the genes encoding these peptides has led to the identification of the receptor Toll as an essential component of the fly's host defense system. In addition, these studies have revealed that the response to Gram-negative bacterial infections involves Toll-independent mechanisms, and that the sensing of infection involves two structurally distinct sets of molecules — the PGRPs and the GNBPs/βGRPs.
Type of Medium:
Online Resource
ISSN:
0968-0519
DOI:
10.1177/09680519040100040701
Language:
English
Publisher:
SAGE Publications
Publication Date:
2004
detail.hit.zdb_id:
2381250-3
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