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  • 1
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    Online Resource
    Hearing restoration for adults with vestibular schwannoma in the only-hearing ear: ipsilateral, contralateral or bilateral cochlear implantation? : Presenting Author: Zhihua Zhang
    Cambridge University Press (CUP) ; 2016
    In:  The Journal of Laryngology & Otology Vol. 130, No. S3 ( 2016-05), p. S253-S254
    Details
    In: The Journal of Laryngology & Otology, Cambridge University Press (CUP), Vol. 130, No. S3 ( 2016-05), p. S253-S254
    Type of Medium: Online Resource
    ISSN: 0022-2151 , 1748-5460
    URL: Article
    DOI: 10.1017/S0022215116007441
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2016
    detail.hit.zdb_id: 2013209-8
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  • 2
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    3D printing‐assisted combinatorial approach for designing mechanically‐tunable and vascular supportive nanofibrous membranes to repair perforated eardrum
    Wiley ; 2021
    In:  Journal of Applied Polymer Science Vol. 138, No. 14 ( 2021-04-10)
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 138, No. 14 ( 2021-04-10)
    Abstract: Perforation of eardrum or tympanic membrane (TM) is a common clinical condition, which occurs due to infection or injury of the eardrum, and could results in varying degrees of conductive hearing loss among all ages. In this study, the authors report the combinatorial approach of designing mechanically‐tunable and vascular supportive nanofibrous membranes by 3D printing‐assisted electrospinning (e‐spin) using polycaprolactone (PCL) and gelatin with different mass ratios suitable to repair a perforated eardrum. The physicochemical, mechanical, and biological properties of the membranes were characterized. The results show that the membrane has nanofibrous morphology with fibers are of varying size (400–600 nm in diameter) depending on processing conditions. The wettability and mechanical properties of the membrane can be tuned by regulating the gelatin content. Moreover, a biomimetic repair strategy inspired by chicken eggshell membrane, often used in wound dressings, was also presented for study and results show that the suture retention strength of the fabricated membrane can meet clinical translational requirements to promote TM healing. The vascular cell responsiveness of PCL/gelatin nanofibrous membrane was evaluated using human umbilical vein endothelial cells (HUVECs) and the results showed satisfactory biocompatibility, vascular cell responsiveness, and cell proliferation. The findings of this study demonstrate that the combinatorically engineered PCL/gelatin nanofibrous membrane has great potential for repairing perforated eardrum.
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v138.14
    DOI: 10.1002/app.50132
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1491105-X
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  • 3
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    Hypomethylation and downregulation of miR-23b-3p are associated with upregulated PLAU: a diagnostic and prognostic biomarker in head and neck squamous cell carcinoma
    Springer Science and Business Media LLC ; 2021
    In:  Cancer Cell International Vol. 21, No. 1 ( 2021-12)
    Details
    In: Cancer Cell International, Springer Science and Business Media LLC, Vol. 21, No. 1 ( 2021-12)
    Abstract: DNA methylation and miRNA-target genes play an important part in the early development of various tumors and have been studied as tumor biomarkers. Although previous studies have reported a cluster of molecular events (such as aberrant alterations of genomics and epigenetics), little is known of the potential biomarkers for early diagnosis and prognostic evaluation in head and neck squamous cell carcinoma (HNSCC). Methods Multiple bioinformatics tools based on The Cancer Genome Atlas (TCGA) database and clinical samples were applied to evaluate the beneficial biomarkers in HNSCC. We focused on the role of plasminogen activator urokinase (PLAU), including diagnostic and prognostic significance, gene expression analysis, aberrant DNA methylation characteristics, interaction of miRNAs and associated signaling pathways. Results We found that PLAU was aberrantly upregulated in HNSCC, regardless of the mRNA or protein level. The results of receiver operating characteristic (ROC) curve and Cox regression analysis revealed that PLAU was a diagnostic and independent prognostic factor for patients with HNSCC. Hypomethylation of PLAU was closely related to poor survival in HNSCC. Additionally, miR-23b-3p was predicted to target PLAU and was significantly downregulated in HNSCC tissues. Therefore, our findings suggested that PLAU functioned as a promoter in the pathological process of HNSCC. DNA hypomethylation and downregulation of miR-23b-3p were associated with PLAU overexpression. Finally, our findings provided evidence of a significant interaction between PLAU-target and miRNAs-target pathways, indicating that miR-23b-3p suppresses malignant properties of HNSCC by targeting PLAU via Ras/MAPK and Akt/mTOR signaling pathways. Conclusions PLAU is overexpressed and may serve as an independent diagnostic and prognostic biomarker in HNSCC. Hypomethylation and downregulation of miR-23b-3p might account for the oncogenic role of PLAU in HNSCC.
    Type of Medium: Online Resource
    ISSN: 1475-2867
    URL: Article
    DOI: 10.1186/s12935-021-02251-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2091573-1
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  • 4
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    Prognostic Factors of Long-Term Hearing Preservation in Small and Medium-Sized Vestibular Schwannomas After Microsurgery
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Otology & Neurotology Vol. 40, No. 7 ( 2019-08), p. 957-964
    Details
    In: Otology & Neurotology, Ovid Technologies (Wolters Kluwer Health), Vol. 40, No. 7 ( 2019-08), p. 957-964
    Abstract: The authors evaluated the long-term hearing outcomes of patients with vestibular schwannoma (VS) to explore appropriate surgical treatment. Study Design: Retrospective study. Setting: Tertiary referral center. Patients: A total of 138 patients diagnosed with small and medium-sized VS with serviceable hearing from January 2006 to December 2015. Interventions: All patients underwent microsurgery via retrosigmoid (RSA) or middle cranial fossa approach (MFA) and were followed up for over 2 years. Main Outcome Measures: Pre- and postoperative hearing, including pure tone audiometry, speech discrimination score, and auditory brainstem response (ABR), were analyzed. Results: The mean tumor size and volume were 16.6 ± 3.4 mm and 1711.8 ± 918.5 mm 3 , respectively. Preoperative hearing levels were Class A in 42, Class B in 67, and Class C in 29 patients. Patients with a tumor from the superior vestibular nerve (SVN) had better hearing at diagnosis. Postoperative hearing levels were Class A, B, C, and D for 28, 17, 32, and 61 patients. Hearing outcomes were significantly better in patients with normal intraoperative I wave on ABR. Hearing loss within 6 months had a positive effect on postoperative hearing. Better preoperative hearing and tumors from SVN were correlated with better postoperative hearing outcomes. Tumor size, cystic variation, or extension to the fundus of internal auditory canal had no influence on hearing preservation. Conclusions: Better preoperative hearing, shorter hearing loss period, tumors from SVN, and normal intraoperative I wave are prognostic factors for serviceable hearing. RSA and MFA are effective and safe for tumor removal and hearing preservation.
    Type of Medium: Online Resource
    ISSN: 1531-7129 , 1537-4505
    URL: Article
    DOI: 10.1097/MAO.0000000000002284
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2058738-7
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  • 5
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    Experimental study on operating parameters of miniature loop heat pipe with flat evaporator
    Elsevier BV ; 2012
    In:  Applied Thermal Engineering Vol. 40 ( 2012-07), p. 318-325
    Details
    In: Applied Thermal Engineering, Elsevier BV, Vol. 40 ( 2012-07), p. 318-325
    Type of Medium: Online Resource
    ISSN: 1359-4311
    URL: Article
    DOI: 10.1016/j.applthermaleng.2012.02.029
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 2019322-1
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  • 6
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    Effect of membrane electrode assembly design on the cold start process of proton exchange membrane fuel cells
    Elsevier BV ; 2017
    In:  International Journal of Hydrogen Energy Vol. 42, No. 40 ( 2017-10), p. 25372-25387
    Details
    In: International Journal of Hydrogen Energy, Elsevier BV, Vol. 42, No. 40 ( 2017-10), p. 25372-25387
    Type of Medium: Online Resource
    ISSN: 0360-3199
    URL: Article
    DOI: 10.1016/j.ijhydene.2017.08.106
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2017
    detail.hit.zdb_id: 1484487-4
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  • 7
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    Prognostic factors for hearing outcomes in patients that undergo adjuvant hyperbaric oxygen therapy for sudden sensorineural hearing loss
    Wiley ; 2022
    In:  Laryngoscope Investigative Otolaryngology Vol. 7, No. 2 ( 2022-04), p. 592-598
    Details
    In: Laryngoscope Investigative Otolaryngology, Wiley, Vol. 7, No. 2 ( 2022-04), p. 592-598
    Abstract: The aim of this study is to explore the potential factors in hearing outcomes and verify the role of oxidant‐antioxidant equilibrium on the prognosis of sudden sensorineural hearing loss (SSNHL) treated with hyperbaric oxygen therapy (HBOT). Methods Ninety‐two patients who were diagnosed with SSNHL between January 2018 and December 2019 in our hearing clinic center were included in this study. All patients were treated with intravenous dexamethasone, and 72 cases were treated with additional HBOT for 10 consecutive days. Peripheral blood was collected prior to any treatment to determine the blood cell count and hemoglobin (HGB), hematocrit (HCT), and superoxide dismutase (SOD) levels. Pure tone audiometry was measured before and after treatment. Complete and overall recovery rate was evaluated. Multivariate logistic analysis was used to identify prognostic factors. Results The rate of overall recovery was significantly higher in the patient with combined therapy compared to patients treated with steroids only (51.4% vs 25.0%, p  = .036). The levels of HGB, HCT, and SOD were much higher in the patients with better hearing outcomes ( p  = .027, .033, and .011, respectively). Multivariate logistic analysis demonstrated that patients with higher initial hearing thresholds, or hearing loss at overall frequency, were more prone to have poor hearing gains after HBOT. Conclusion HBOT is effective as an early adjuvant therapy for SSNHL. Hearing loss at low frequency, low initial hearing thresholds, as well as high HBG, HCT, and SOD levels are positive prognostic factors for SSNHL patients treated with HBOT.
    Type of Medium: Online Resource
    ISSN: 2378-8038 , 2378-8038
    URL: Issue
    URL: Article
    DOI: 10.1002/lio2.v7.2
    DOI: 10.1002/lio2.768
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2851702-7
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  • 8
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    Epoxidized natural rubber grafted polyacrylamide and their polypyrrole composites for functional application
    Elsevier BV ; 2024
    In:  Industrial Crops and Products Vol. 213 ( 2024-07), p. 118453-
    Details
    In: Industrial Crops and Products, Elsevier BV, Vol. 213 ( 2024-07), p. 118453-
    Type of Medium: Online Resource
    ISSN: 0926-6690
    URL: Article
    DOI: 10.1016/j.indcrop.2024.118453
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 1483245-8
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  • 9
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    Fault location of cable hybrid transmission lines based on energy attenuation characteristics of traveling waves
    Springer Science and Business Media LLC ; 2022
    In:  Scientific Reports Vol. 12, No. 1 ( 2022-12-27)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-12-27)
    Abstract: The overhead-cable hybrid transmission lines are alternately connected by two types of lines, with a more complex structure and higher difficulty in fault location. This paper presents an ac-curate fault location method for overhead-cable hybrid lines based on traveling wave energy. Firstly, the basic concept of traveling wave energy is defined. Based on the attenuation charac-teristics of the traveling wave, the mapping relationship between traveling wave energy and fault location is analyzed. Secondly, considering the influence of S-transform error on the traveling wave energy propagation law, the traveling wave energy attenuation characteristics of common A-type and B-type hybrid lines are analyzed. Then, for the overhead-cable hybrid lines with different structures, the mapping relationship between the traveling wave energy at both ends of the line and the fault distance is quantitatively derived, and an accurate fault location method based on the initial traveling wave energy ratio at the same frequency at both ends of the line is proposed. Finally, a 110 kV hybrid transmission line fault simulation model is built in PSCAD/EMTDC, and the faults under different conditions are simulated in different line sections. The effectiveness and robustness of the proposed method are verified through the simulation.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-022-25976-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2615211-3
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  • 10
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    The relationship between allergic status and adenotonsillar regrowth: a retrospective research on children after adenotonsillectomy
    Springer Science and Business Media LLC ; 2017
    In:  Scientific Reports Vol. 7, No. 1 ( 2017-04-18)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2017-04-18)
    Abstract: Adenotonsillar regrowth in children after adenotonsillectomy (T & A) for obstructive sleep apnea (OSA) is often seen in clinical treatment, however, the relationship between allergic disease and adenotonsillar regrowth remains unclear. In this retrospective study, children were assigned to either the recurrence or control group, and subdivided by age at operation. Among children over 36 months, those in the recurrence group had more allergic disease and higher IgE, IL-4, and IL-5 levels than the same-aged children in control group. The Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) scores for nasal symptoms and activity were higher in children older than 36 months in recurrence group. The results of immunohistochemistry and immunofluorescence showed that FoxP3+ cells (Tregs) were less, while GATA3+ cells (Th2 cells) were more in recurrence group for all ages. Allergic status and low levels of FoxP3 were proved as independent risk factors for adenotonsillar regrowth by multivariate logistic regression. These results indicate that allergic disease is a risk factor for adenotonsillar regrowth in children following T & A for OSA, and this risk increases with age. The decreased level of Tregs and subsequent changes in immune function play an important role in the pathogenesis of adenotonsillar regrowth.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/srep46615
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2615211-3
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