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  • 1
    Online Resource
    Online Resource
    Whole fresh fruit intake and risk of incident diabetes in different glycemic stages: a nationwide prospective cohort investigation
    Springer Science and Business Media LLC ; 2022
    In:  European Journal of Nutrition
    Details
    In: European Journal of Nutrition, Springer Science and Business Media LLC
    Abstract: Fruit intake is beneficial to several chronic diseases, but controversial in diabetes. We aimed to investigate prospectively the associations of whole fresh fruit intake with risk of incident type 2 diabetes (T2D) in subjects with different glucose regulation capacities. Methods The present study included 79,922 non-diabetic participants aged ≥ 40 years from an ongoing nationwide prospective cohort in China. Baseline fruit intake information was collected by a validated food frequency questionnaire. Plasma HbA1c, fasting and 2 h post-loading glucose levels were measured at both baseline and follow-up examinations. Cox proportional hazards models were used to calculate hazard ratio (HR) and 95% confidence intervals (CI) for incident diabetes among participants with normal glucose tolerance (NGT) and prediabetes, after adjusted for multiple confounders. Restricted cubic spline analysis was applied for dose–response relation. Results During a median 3.8-year follow-up, 5886 (7.36%) participants developed diabetes. Overall, we identified a linear and dose-dependent inverse association between dietary whole fresh fruit intake and risk of incident T2D. Each 100 g/d higher fruit intake was associated with 2.8% lower risk of diabetes (HR 0.972, 95%CI [0.949–0.996], P  = 0.0217), majorly benefiting NGT subjects with 15.2% lower risk (HR 0.848, 95%CI [0.766–0.940], P  = 0.0017), while not significant in prediabetes (HR 0.981, 95%CI 0.957–4.005, P  = 0.1268). Similarly, the inverse association was present in normoglycemia individuals with a 48.6% lower risk of diabetes when consuming fruits  〉  7 times/week comparing to those  〈  1 time/week (HR 0.514, 95% CI [0.368–0.948]), but not in prediabetes (HR 0.883, 95% CI [0.762–1.023] ). Conclusion These findings suggest that higher frequency and amount of fresh fruit intake may protect against incident T2D, especially in NGT, but not in prediabetes, highlighting the dietary recommendation of higher fresh fruit consumption to prevent T2D in normoglycemia population.
    Type of Medium: Online Resource
    ISSN: 1436-6207 , 1436-6215
    URL: Article
    DOI: 10.1007/s00394-022-02998-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1463312-7
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  • 2
    Online Resource
    Online Resource
    Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis
    American Association for Cancer Research (AACR) ; 2019
    In:  Clinical Cancer Research Vol. 25, No. 4 ( 2019-02-15), p. 1318-1330
    Details
    In: Clinical Cancer Research, American Association for Cancer Research (AACR), Vol. 25, No. 4 ( 2019-02-15), p. 1318-1330
    Abstract: Extensive research has reported that the tumor microenvironment components play crucial roles in tumor progression. Thus, blocking the supports of tumor microenvironment is a promising approach to prevent cancer progression. We aimed to determine whether blocking extracellular ATP–P2RY2 axis could be a potential therapeutic approach for PDAC treatment. Experimental Design: Expression of P2RY2 was determined in 264 human PDAC samples and correlated to patient survival. P2RY2 was inhibited in human PDAC cell lines by antagonist and shRNA, respectively, and cell viability, clonogenicity, and glycolysis were determined. RNA sequencing of PDAC cell line was applied to reveal underlying molecular mechanisms. Multiple PDAC mouse models were used to assess the effects of the P2RY2 inhibition on PDAC progression. Results: P2RY2 was upregulated and associated with poor prognosis in PDAC. Activated P2RY2 by increased extracellular ATP in tumor microenvironment promoted PDAC growth and glycolysis. Further studies showed that the agonist-activated P2RY2 triggered PI3K/AKT–mTOR signaling by crosstalk with PDGFR mediated by Yes1, resulting in elevated expression of c-Myc and HIF1α, which subsequently enhanced cancer cell glycolysis. Genetic and pharmacologic inhibition of P2RY2 impaired tumor cell growth in subcutaneous and orthotopic xenograft model, as well as delayed tumor progression in inflammation-driven PDAC model. In addition, synergy was observed when AR-C118925XX, the selective antagonist of P2RY2 receptor, and gemcitabine were combined, resulting in prolonged survival of xenografted PDAC mice. Conclusions: These findings reveal the roles of the P2RY2 in PDAC metabolic reprogramming, suggesting that P2RY2 might be a potential metabolic therapeutic target for PDAC.
    Type of Medium: Online Resource
    ISSN: 1078-0432 , 1557-3265
    URL: Article
    DOI: 10.1158/1078-0432.CCR-18-2297
    RVK:
    XA 36791
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2019
    detail.hit.zdb_id: 1225457-5
    detail.hit.zdb_id: 2036787-9
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  • 3
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    General Anesthesia vs Conscious Sedation for Endovascular Treatment in Patients With Posterior Circulation Acute Ischemic Stroke : An Exploratory Randomized Clinical Trial
    American Medical Association (AMA) ; 2023
    In:  JAMA Neurology Vol. 80, No. 1 ( 2023-01-01), p. 64-
    Details
    In: JAMA Neurology, American Medical Association (AMA), Vol. 80, No. 1 ( 2023-01-01), p. 64-
    Abstract: No definitive conclusion can be made on the best choice of anesthesia for people with acute posterior circulation stroke during endovascular treatment. Only a few observational studies have focused on this topic in recent years, and they have differing conclusions. Objective To examine whether conscious sedation (CS) is a feasible alternative to general anesthesia (GA) during endovascular treatment in patients with acute posterior circulation stroke. Design, Setting, and Participants A randomized parallel-group exploratory trial with blinded end point evaluation (Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke [CANVAS II]) enrolled adult patients from March 2018 to June 2021 at 2 comprehensive care hospitals in China. Patients with acute posterior circulation stroke were enrolled, randomized, and monitored for 3 months. Of 210 patients admitted with acute ischemic posterior circulation stroke, 93 were recruited and 87 were included in the intention-to-treat (ITT) analysis after exclusions, 43 were assigned to GA and 44 to CS. All analyses were unadjusted or adjusted with the ITT principle. Interventions Participants were randomly assigned to CS or GA in a 1:1 ratio. Main Outcomes and Measures The primary end point was functional independence at 90 days evaluated with the modified Rankin Scale (mRS). Results A total of 87 participants were included in the ITT study (mean [SD] age, 62 [12] years; 16 [18.4%] female and 71 [81.6%] male). Of these, 43 were in the GA group and 44 in the CS group. The overall baseline median (IQR) National Institute of Health Stroke Scale (NIHSS) score was 15 (12-17). In the CS group, 13 people (29.5%) were ultimately transferred to GA. The CS group had a higher incidence of functional independence; however, no significant difference was found between the 2 groups (48.8% vs 54.5%; risk ratio, 0.89; 95% CI, 0.58-1.38; adjusted odds ratio [OR], 0.91; 95% CI, 0.37-2.22). However, GA performed better in successful reperfusion (mTICI 2b-3) under ITT analysis (95.3% vs 77.3%; adjusted OR, 5.86; 95% CI, 1.16-29.53). Conclusion and Relevance The findings in this study suggest that CS was not better than GA for the primary outcome of functional recovery and was perhaps worse for the secondary outcome of successful reperfusion. Trial Registration ClinicalTrials.gov Identifier: NCT03317535
    Type of Medium: Online Resource
    ISSN: 2168-6149
    URL: Article
    DOI: 10.1001/jamaneurol.2022.3018
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
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  • 4
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    Online Resource
    Identification of Heterophilic Epitopes of H1N1 Influenza Virus Hemagglutinin
    Springer Science and Business Media LLC ; 2023
    In:  Current Microbiology Vol. 80, No. 5 ( 2023-05)
    Details
    In: Current Microbiology, Springer Science and Business Media LLC, Vol. 80, No. 5 ( 2023-05)
    Type of Medium: Online Resource
    ISSN: 0343-8651 , 1432-0991
    URL: Article
    DOI: 10.1007/s00284-023-03294-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1458987-4
    SSG: 12
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  • 5
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    Glycemic status and chronic kidney disease in C hinese adults: F indings from the REACTION study : 中国成年人糖代谢状态与慢性肾脏疾病的相关性:来自REACTION的研究发现
    Wiley ; 2017
    In:  Journal of Diabetes Vol. 9, No. 9 ( 2017-09), p. 837-845
    Details
    In: Journal of Diabetes, Wiley, Vol. 9, No. 9 ( 2017-09), p. 837-845
    Abstract: 既往研究证实已诊断的糖尿病与慢性肾脏疾病(chronic kidney disease,CKD)具有相关性。然而,关于糖尿病前期高血糖是否与升高的CKD风险有关尚不明确。本研究旨在探讨中国成年人群不同糖代谢水平与CKD的相关性,并评估和讨论CKD患者的糖尿病患病率及血糖控制现状。 方法 本研究共纳入250752名40岁及以上受试者,均来自中国2型糖尿病患者恶性肿瘤发生风险的流行病学研究(Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study,REACTION study)的基线研究人群,并对所有受试者进行血糖、生化检测以及其他临床资料的收集。估算的肾小球滤过率(eGFR) 〈 60mL/min/1.73m 2 被定义为CKD。 结果 在男性和女性中,均可以观察到CKD的患病率随着糖代谢状态的恶化逐渐升高(男性和女性均为趋势 P 〈 0.001)。在男性中,与糖代谢正常的受试者相比,糖尿病前期与糖尿病人群的CKD患病风险增高(糖尿病前期:OR=1.15,95% CI = 1.02‐1.32;新诊断糖尿病:OR=1.27, 95% CI = 1.08‐1.49;已诊断糖尿病:OR=2.05,95% CI = 1.78‐2.35)。在女性中也发现了糖尿病与CKD患病风险的相关性,但是,女性糖尿病前期人群与CKD患病的相关性无统计学意义。在伴有糖尿病的男性CKD患者中,接受降糖治疗的比例是52.1%,其中41.8%患者的糖尿病得到了有效控制,该比例高于女性人群。 结论 在中国40岁及以上成年男性中,糖尿病前期状态和糖尿病与CKD患病风险的升高密切相关。中国CKD患者中血糖的控制情况不容乐观。
    Type of Medium: Online Resource
    ISSN: 1753-0393 , 1753-0407
    URL: Issue
    URL: Article
    DOI: 10.1111/jdb.2017.9.issue-9
    DOI: 10.1111/1753-0407.12490
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2485432-3
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  • 6
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    Isotemporal substitution of different behaviour patterns with the presence of MAFLD in Chinese adults
    Wiley ; 2022
    In:  Liver International Vol. 42, No. 12 ( 2022-12), p. 2683-2695
    Details
    In: Liver International, Wiley, Vol. 42, No. 12 ( 2022-12), p. 2683-2695
    Abstract: Lack of physical activity and excessive sitting time contributed to ectopic fat accumulation, especially in the liver. Previous studies have illustrated the harm of sedentary behaviour and the benefits of physical activity on fatty liver disease. We aimed to explore the association between the behaviour patterns and the risk of metabolic dysfunction‐associated fatty liver disease (MAFLD) using isotemporal substitution model to examine the effect of replacing one behaviour to another while keeping the total time and other behaviours fixed among Chinese middle‐aged and elderly population. Methods This study included 161 147 participants aged ≥40 years old from the nationwide, population‐based cohort of the REACTION study. The International Physical Activity Questionnaire was used to measure self‐reported time for sleeping, sitting, walking and moderate‐to‐vigorous physical activity (MVPA). MAFLD was defined by evidence of fatty liver index (FLI) ≥ 60 in addition to one of the following three patterns, namely overweight/obesity, presence of diabetes, or evidence of metabolic dysregulation. Isotemporal substitution models using logistic regression models to evaluate the association of replacement of different behaviour patterns with each other and the risk of MAFLD. Results Substitution of 60 minutes per day of sleeping, walking or total MVPA for sitting was associated with a 2%–8% reduction of MAFLD risk in overall participants. In employed individuals, replacing sitting time with occupational MVPA or nonoccupational MVPA both could bring benefits to liver steatosis. Stratified analysis found that replacing 60 minutes of sitting time with an equivalent time of other behaviour pattern could reduce approximately 8% of the risk among MAFLD participants with metabolic abnormalities. Such a relationship might be explained by the important mediated role of metabolic elements, such as waist circumference, body mass index, triglycerides and homoeostasis model assessment of insulin resistance. Furthermore, replacing sitting with MVPA showed a stronger association among participants who got enough sleep (sleep duration ≥7 hours per day). Conclusion Replacing sitting with other behaviour patterns could reduce the prevalence of MAFLD, and such substitution effect was much remarkably in individuals with abnormal metabolic status. Observably, obese individuals were more likely to benefit from appropriate changes in behaviour patterns. Moreover, the analysis of sleep duration stratification appealed that the adequacy of individual sleep duration also had a significant impact on the substitution effect. It is worth noting that adjusting the time allocation of behaviour patterns might have a beneficial impact on liver‐metabolic health, and these findings might help us better recognize the importance of reasonable arrangement of behaviour patterns according to the individual's situation.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.v42.12
    DOI: 10.1111/liv.15439
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2124684-1
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  • 7
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    Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Journal of the American Heart Association Vol. 5, No. 7 ( 2016-07-06)
    Details
    In: Journal of the American Heart Association, Ovid Technologies (Wolters Kluwer Health), Vol. 5, No. 7 ( 2016-07-06)
    Abstract: Chronic kidney disease ( CKD ) increases cardiovascular disease ( CVD ) risk. However, the association of mildly reduced kidney function with CVD risk is unclear. Methods and Results This study investigated the association of estimated glomerular filtration rate ( eGFR ) with prevalent CVDs, 10‐year Framingham risk for coronary heart disease ( CHD ), and 10‐year risk of atherosclerotic cardiovascular diseases ( ASCVD ) in 239 832 participants from the baseline of the Risk Evaluation of cA ncers in Chinese diabeTic Individuals: a lON gitudinal study. With an interviewer‐assisted questionnaire, we collected information on CVD , including reported CHD , stroke, or myocardial infarction. Chronic Kidney Disease–Epidemiology Collaboration ( CKD ‐ EPI ) equation was used to calculate eGFR . Compared with individuals with normal eGFR (≥90 mL/min per 1.73 m 2 ), those with decreased eGFR (75–89, 60–74, and 〈 60 mL/min per 1.73 m 2 ) had higher risk of prevalent obesity, diabetes mellitus, hypertension, and dyslipidemia in both men and women ( P for trend all 〈 0.001). Moreover, a significantly higher 10‐year Framingham risk for CHD and 10‐year risk for ASCVD was observed in both men and women with mildly decreased eGFR (60–89 mL/min per 1.73 m 2 ). Conclusions Even mildly reduced eGFR (under 90 mL/min per 1.73 m 2 ) is associated with elevated 10‐year Framingham risk for CHD and 10‐year ASCVD risk among Chinese adults.
    Type of Medium: Online Resource
    ISSN: 2047-9980
    URL: Article
    DOI: 10.1161/JAHA.116.003328
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 2653953-6
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  • 8
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    Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus
    Wiley ; 2016
    In:  Obesity Vol. 24, No. 3 ( 2016-03), p. 703-709
    Details
    In: Obesity, Wiley, Vol. 24, No. 3 ( 2016-03), p. 703-709
    Abstract: To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. Methods This study included 120,666 middle‐aged and elderly, whose retrospectively self‐reported body weight at 20 and 40 years and measured height were available. BMI at 20 and 40 years and BMI change in between were defined as early‐adulthood BMI, midlife BMI, and early‐adulthood BMI change. Results The odds ratio (OR) for T2DM associated with an 1‐unit increment of early‐adulthood or midlife BMI was 1.08 (95% confidence interval (CI), 1.07‐1.08) and 1.09 (95% CI, 1.09‐1.10) respectively. In the cross‐tabulation of both early‐adulthood BMI and BMI change, the prevalence of T2DM increased across both variables. Compared with participants with normal early‐adulthood weight and BMI increase/decrease ≤1, the OR (95% CI) for T2DM of participants with early‐adulthood overweight/obesity and BMI increase ≥4 kg/m 2 was 3.49 (3.05‐4.00). For participants with early‐adulthood underweight and BMI increase/decrease ≤ 1, the OR (95% CI) was 0.85 (0.75‐0.97). Subgroup analysis according to sex and age showed similar trends. Conclusions Early‐adulthood BMI may influence T2DM prevalence after midlife independent of current BMI. T2DM prevalence after midlife was positively associated with early‐adulthood weight gain and inversely related to early‐adulthood weight loss, while early‐adulthood weight loss could not completely negate the adverse effect of early‐adulthood overweight/obesity on diabetes.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Issue
    URL: Article
    DOI: 10.1002/oby.v24.3
    DOI: 10.1002/oby.21336
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2027211-X
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  • 9
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    Table_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Endocrinology Vol. 13 ( 2022-7-19)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-7-19)
    Abstract: To determine the effect of decade-based body weight gain from 20 to 50 years of age on later life diabetes risk. Methods 35,611 non-diabetic participants aged ≥ 50 years from a well-defined nationwide cohort were followed up for average of 3.6 years, with cardiovascular diseases and cancers at baseline were excluded. Body weight at 20, 30, 40, and 50 years was reported. The overall 30 years and each 10-year weight gain were calculated from the early and middle life. Cox regression models were used to estimate risks of incident diabetes. Results After 127,745.26 person-years of follow-up, 2,789 incident diabetes were identified (incidence rate, 2.18%) in 25,289 women (mean weight gain 20-50 years, 7.60 kg) and 10,322 men (7.93 kg). Each 10-kg weight gain over the 30 years was significantly associated with a 39.7% increased risk of incident diabetes (95% confidence interval [CI], 1.33-1.47); weight gain from 20-30 years showed a more prominent effect on the risk of developing diabetes before 60 years than that of after 60 years (Hazard ratio, HR = 1.084, 95% CI [1.049-1.121] , P & lt; 0.0001 vs. 1.015 [0.975-1.056], P = 0.4643; P Interaction =0.0293). It showed a stable effect of the three 10-year intervals weight gain on risk of diabetes after 60 years (HR=1.055, 1.038, 1.043, respectively, all P & lt; 0.0036). Conclusions The early life weight gain showed a more prominent effect on developing diabetes before 60 years than after 60 years; however, each-decade weight gain from 20 to 50 years showed a similar effect on risk developing diabetes after 60 years.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    URL: Article
    DOI: 10.3389/fendo.2022.927067
    DOI: 10.3389/fendo.2022.927067.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2592084-4
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  • 10
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    Data_Sheet_1.doc
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-5-26)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-5-26)
    Abstract: We aimed to evaluate the association between depression and major cardiovascular events and test whether the relationship between depression and cardiovascular events is influenced by lifestyle or metabolic risk factors. Methods The China Cardiometabolic Disease and Cancer Cohort (4C) Study was a nationwide, multicenter, prospective cohort study. About 92,869 participants without cardiovascular disease or cancer at baseline were included. Depression status was evaluated by the Patient Health Questionnaire-9 (PHQ-9). Lifestyle information was collected by the questionnaire, and metabolic risk factors including waist circumference, blood pressure, lipid profiles, and plasma glucose were measured. Major cardiovascular events including cardiovascular death, myocardial infarction, stroke, and hospitalized or treated heart failure events were validated based on medical records. Results During an average of 3.8 years of follow-up, we detected 2,076 cardiovascular events and showed that participants with depressive symptoms had an increased risk for cardiovascular events after adjustments [hazard ratio (HR): 1.29; 95% confidence index (CI): 1.08–1.53]. Stratified on metabolic risk status, the relationship between depression and cardiovascular events tended to be stronger according to the increasing numbers of metabolic risk factors, with HR (95% CI) of 0.98 (0.72–1.35) in the category with 0–2 metabolic risk factors, 1.36 (0.996–1.87) and 1.47 (1.13–1.92) for those with 3, and 4–5 metabolic risk factors, respectively, indicating an interaction effect ( P = 0.039). Conclusion Depression was independently associated with an increased risk of major cardiovascular events. The effect was particularly prominent among populations at higher metabolic risk.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.865063
    DOI: 10.3389/fcvm.2022.865063.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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