In:
Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 39, No. 5 ( 2002-05), p. 996-999
Abstract:
The aim of the present study was to investigate whether plasma concentration of proANP 1–30 , the N-terminal fragment of the atrial natriuretic peptide prohormone, or 24-hour urinary excretion of urodilatin reflects the degree of salt sensitivity in hypertension-prone individuals. Plasma concentration of proANP 1–30 and urinary urodilatin excretion were determined at baseline, after 1 week on a low-salt diet (10 mmol/d) and after another week on a high-salt diet (240 mmol/d) in 30 healthy subjects with heredity for hypertension. Salt sensitivity was defined as the difference between mean arterial blood pressure after the high-salt diet and the mean arterial blood pressure after the low-salt diet. High- versus low-salt intake increased proANP 1–30 (668±330 versus 358±150 pmol/L; P 〈 0.00001) and urodilatin (18.7±5.2 versus 16.0±8.3 pmol/24 h; P 〈 0.05). ProANP 1–30 correlated with salt sensitivity at baseline ( r =0.76, P 〈 0.000001), after the low- ( r =0.80, P 〈 0.0000001) and high-salt diets ( r =0.85, P 〈 0.00000001). The increase in proANP 1–30 induced by changing from the low- to the high-salt diet was also directly related to salt sensitivity ( r =0.78, P 〈 0.000001). ProANP 1–30 was not related to urinary sodium excretion. Neither urodilatin nor the sodium-induced change in urodilatin correlated with salt sensitivity. However, urodilatin was related to the urinary sodium excretion at baseline ( r =0.58, P 〈 0.01) and after the high-salt diet ( r =0.62, P 〈 0.001). In conclusion, the close correlations between proANP 1–30 and salt sensitivity suggest that proANP 1–30 may serve as a marker for salt sensitivity and could be useful in identifying subjects who would benefit from dietary salt restriction to prevent development of hypertension.
Type of Medium:
Online Resource
ISSN:
0194-911X
,
1524-4563
DOI:
10.1161/01.HYP.0000017552.91014.2A
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2002
detail.hit.zdb_id:
2094210-2
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