In:
Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 71, No. 8 ( 1974-08), p. 3143-3146
Abstract:
The translations of native messenger RNA for rabbit globin and that of poly(A)-free globin messenger RNA have been compared after injection into Xenopus oocytes. The initial rate of translation of poly(A)-free mRNA is close to that found with intact mRNA. However, at longer incubation periods, the rate of globin synthesis with poly(A)-free mRNA is considerably lower than with native mRNA. Similar differences in the template activity of the two mRNA preparations were found with a cell-free extract of Krebs II ascites tumor. It is concluded that the presence of the 3′ poly(A)-rich sequence in mRNA is required to ensure high functional stability.
Type of Medium:
Online Resource
ISSN:
0027-8424
,
1091-6490
DOI:
10.1073/pnas.71.8.3143
Language:
English
Publisher:
Proceedings of the National Academy of Sciences
Publication Date:
1974
detail.hit.zdb_id:
209104-5
detail.hit.zdb_id:
1461794-8
SSG:
11
SSG:
12
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